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  • Imunski depoziti in histopatologija vnetnega odziva pri sistemskem lupusu eritematozusu = Immune deposits and histopathology of inflammatory reaction in systemic lupus erythematosus
    Ferluga, Dušan, 1934- ; Hvala, Anastazija ; Vizjak, Alenka, 1947-
    A review of hypotheses on the etiopathogenesis of systemic lupus erythematosus(SLE) is presented in the introduction of this paper. Our study explored the relationship between glomerular immune ... deposits and local inflammatory reaction by light, immunofluorescence and electron microscopic methods on 333 biopsy and 37 autopsy kidney samples of 267 SLE patients. Glomerular immune deposits were found to be present in 99% of patients. The prevalence of immune deposits in other parts of the nephron, as well as in other organs, was significantly lower. A full-house pattern by immunofluorescence and mesangial-transmembranous distribution of immune deposits were confirmed as characteristic for SLE. Histomorphologically, a characteristic mixed mebranous and proliferative pattern of inflammatory reaction was found in one third of SLE patients, while patterns chaacterizing various forms of isolated glomerulonephritis, were observed in others. The diagnostic and prognostic significance of the glomerular immune deposit distribution pattern as well as its correlation with the inflammatory reactionand WHO classes of lupus glomerulonephritis were revealed. There was often no correlation found between immune deposits and inflammatory reaction in other organs, which will be the subject of our future investigation.
    Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 38, supl. 7, nov. 1999, str. 45-53)
    Vrsta gradiva - članek, sestavni del
    Leto - 1999
    Jezik - slovenski
    COBISS.SI-ID - 10932953

vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 38, supl. 7, nov. 1999, str. 45-53)

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