Narodna in univerzitetna knjižnica, Ljubljana (NUK)
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Novejši pogledi na tuberkulinski test = Tuberculin test - new aspectsSkralovnik-Štern, Aleksandra ...Host immunity plays an important role in the host-pathogen interaction occuring in persons exposed to Mycobacterium tuberculosis. In the last few years, numerous in vitro studies made it possible to ... define the type and number of cells which produce cytokines, the interactions between them and to reveal the concentrations in which cytokines are produced. In clinical practice there is a recognized need for a better, faster, more sensitive and evaluable in vitro tuberculin test which would require no return visit for skin test reading and no painful local reactions. In 11 healthy persons, interferon gamma assay and a novel CD 69 antigen determination after stimulation of whole blood with PPD correlate with their tuberculin skin tests. It takes only 24 hours to obtain the results. Blast transformation test, the fundamental test for the evaluation of the role of lymphocytes in vitro, also correlates with the interferon gamma assay and CD 69 antigen determination. Further studies are planned to adress the issue of sensitivity and specificity, especially in immunosupressed patients (these are patients after transplantation, those receiving immunosupressive drugs and those infected with HIV). Systemic effects of tuberculin, well known from Koch's experiments with intradernal challenge of tuberculosis patients with large quantities of tuberculin, are of interest again. Booster effect - the phenomenon of increased tuberculin skin reaction upon retesting after a few days - is believed to result from the reactivation of the preexisting delayed type hypersensitivity and indicates the systemic effects of tuberculin skin tests which are believed to be safe and often repeatable.Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 38, supl. 7, nov. 1999, str. 113-119)Vrsta gradiva - članek, sestavni delLeto - 1999Jezik - slovenskiCOBISS.SI-ID - 10935769
Avtor
Skralovnik-Štern, Aleksandra |
Škoberne, Mojca, 1972- |
Malovrh, Tadej |
Terčelj-Zorman, Marjeta |
Turel, Matjaž
Teme
Tuberculin test |
Trends |
Tuberculosis |
Immunology |
Antigens, CD |
Blood |
Lymphocyte transformation |
tuberkuloza |
imunologija |
diagnostika |
tuberkulinski test |
infekcije
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Skralovnik-Štern, Aleksandra | 15386 |
Škoberne, Mojca, 1972- | 18356 |
Malovrh, Tadej | 16346 |
Terčelj-Zorman, Marjeta | 06661 |
Turel, Matjaž | 15779 |
Vir: Osebne bibliografije
in: SICRIS
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