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  • Dolgoročni uspehi zdravljenja onihomikoze nohtov nog = Long term outcomes in the treatment of toenail onychomycosis
    De Cuyper, Christa
    Background. Little is known about the long term outcome of patients treated for toenail onychomycosis with the new antifungals terbinafine and itraconazole. Material and methods. Between 1991 and ... 1994 our center participated in two multicenter trials, the first comparing two doses of terbinafine 250 mg/day (group I) and 500 mg/day (group II), in a 16-week treatment of toenail onychomycosis, the second comparing terbinafine 250 mg daily and itraconazile 200 mg daily in a 12 week oral treatment of toenail onychomycosis. We analyzed the data of our patients separately and performed along term follow-up of more than two years after the end of each study. Results. A total of 45 patients were enrolled in the first study, 37 completedthe study protocol and were evaluated at week 48 (end of the study). In group I, 89% were clinically cured or had minimal residual lesions; 84% were mycologically negative. In group II, 94% were clinically cured or had minimal residual lesions, 94% were mycologically negative. Thirty-five patients returned for long term follow-up. In group I, 82% were clinically healed of had minimal residual leisons and 82% had negative mycology. In groupII, 94% were clinically cured or had minimal lesions and 83% were mycologically negative. In the second study comparing terbinafine with itraconazole a total of 42 patients were included, 37 completed the study protocol, 34 returned for control two years later. At week 48, 75% in the terbinafine group were clinically cured or had minimal residual lesions, 90% were mycologically negative. (Abstracts truncated at 2000 characters).
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 68, supl. 2, dec. 1999, str. II-13-II-16)
    Vrsta gradiva - članek, sestavni del
    Leto - 1999
    Jezik - slovenski
    COBISS.SI-ID - 10956761

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