Ependymomas in adult patients : results of adjuvant radiotherapy = [Ependimom pri odraslih bolnikih : rezultati zdravljenja z adjuvantno radioterapijo]
Mayer, Ramona ...
Background. As ependymomas are rare tumours and experiences base on the results of retrospective: studies, we assess the survival and pattern of recurrence in eight adult patients with intracranial ...or spinal ependymoma who were treated with adjuvant radiotherapy. Patients and methods. The data of a series of adult patients with low/intermediate (7) or high-grade (1) ependymomas receiving postoperative radiotherapy are presented. Between 1985 and 1994, eight patients (mean age 41 years, range 18-55 years) with intracranial (2) or spinal (6) ependymoma were irradiated either after macroscopically complete surgery (4), or incomplete surgery (1) or for salvageafter incomplete resection of local recurrence (3). Radiotherapy with amean dose of 52 Gy (range, 50-54Gy) was given to generous local fields with boost, not to the entire craniospinal axis. Results. Median follow-up was 101 months (range, 12-146 months); the 5-year overall survival and disease-free survival were 100 % and 8z %, respectively. Infield failure occurred in one patient with intracranial and one with spinal ependymoma 77 months after radiotherapy in both cases. Initially, these two patients had been irradiated after incomplete resection of a recurrent tumour Two patients with spinal cordtumours showed outfield failure in the spinal cord 38 and 86 months after radiotherapy. No irradiation induced late effects were observed. Conclusions. Adjuvant radiotherapy after incomplete surgery and/or local recurrence and/or high-grade tumours seems to be efficient to prolong local control in this raredisease.
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