Fagocitoza in okužbe = Phagocytosis and infectious diseases
Simčič, Saša
Phagocytes express pattern-recognition receptors that recognize conserved molecular patterns shared by large groups of microorganisms. Direct recognition of molecular patterns is mediated via the ...various hydrophobin receptors, Toll-like receptors, integrins and lectin-like receptors such as the mannose receptor. The respective opsonins of Fc, complement or collectin receptors provide the generic pattern. These receptors may play a dual role, firstly in clearance of infectious agents and, secondly, as links between the innate and the adaptive immune responses. Activated phagocytes are capable of generating large amounts of highly toxic molecules either of oxygen or non-oxygen origin that exert antimicrobial activity against infectious agents.In spite of all this, several pathogens can resist this first line defence and therefore thrive within different subcellular compartments. Several cytokines and cytokine-mediated soluble factors play a crucial role inthe control or the killing of intracellular pathogens by phagocytes, and therefore in early host resistance. The evidence for a coop- eration of cytokines with antibiotics in intracellular infection could provide new therapeutic approaches to intracellular infectious diseases in the future.
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