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  • Klopidogrel - nova možnost preprečevanja srčno-žilnih zapletov = Clopidogrel - a new opportunity for preventing cardiovascular complications
    Poredoš, Pavel
    This paper describes an antithrombotic drug, clopidogrel, which inhibits platelet activation through ADP receptors. Clopidogrel significantly reduces the incidence of thromboembolic complications ... inpatients with atherosclerotic disease. Its efficacy has been proven in numerous preclinical and clinical studies. The most relevant results concerning its efficacy were obtained in CAPRIE study. This study showed that clopidogrel prevents complications in patients with myocardial infarction, stroke and peripheral arterial occlusive disease as efficiently as aspirin, or even better. Data obtained to date indicate that clopidogrel is a relatively safe drug. Digestive problems are asfrequent as with other antiplatelet drugs, while gastrointestinal bleeding and disturbances of blood clotting are even less frequent than with aspirin. Serious complications (neutropenia, thrombotic thrombocytopenic purpura), which are associated with ticlopidine, a precursor of clopidogrel; are less frequent with clopidogrel treatment. Clopidogrel can be considered a significant advance in the field of secondary prevention of atherosclerosis. Its use is indicated predominantly in patients with generalized atherosclerosis in whom aspirin is contraindicated.
    Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 40, supl. 1, feb. 2001, str. 141-145)
    Vrsta gradiva - članek, sestavni del
    Leto - 2001
    Jezik - slovenski
    COBISS.SI-ID - 12960473

vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 40, supl. 1, feb. 2001, str. 141-145)

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