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  • Kaj je homocistein? = What is homocysteine?
    Božič, Mojca, 1970-
    Homocysteine is a thiol-containing aminoacid produced as an intermediate in methionine metabolism. It is further metabolised into cystathionine (trans-sulphuration pathway) by ... cystathionine-(beta-synthase with vitamin B6 as acofactor. Another metabolic pathway is remetilation of homocysteine into methionine by methionine synthase with vitamin B12 as a cofactor and methyletetrahydrofolate as the methyl donor. In addition, in the liver betaineserves as a methyl donor and this reaction is catalysed by betaine homocystein methyltransferase. Absent or diminished activity of enzymes, whichparticipate in homocysteine metabolism, or absence of vitamins B12, B6 orfolate cause accumulation of homocysteine - the so called hyperhomocysteinemia. Hyperhomocysteinemia is associated with vascular diseases, pregnancy complications, some of the inherited abnormalities, neuropsychiatric disturbances and cognitive impairment in the elderly.
    Vir: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 53, pos. št., nov. 2002, str. 337-341)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2002
    Jezik - slovenski
    COBISS.SI-ID - 15723481

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