Klaritromicin (Fromilid) v zdravljenju okužb na spodnjih dihalih = Clarithromycin (Fromilid) in the treatment of lower respiratory tract infections
Breznik, Matej, farmacevt
We analyzed prospective clinical studies of clarithromycin (Fromilid) therapy for community-acquired pneumonia and acute exacerbations of chronic bronchitis, which were carried out between 1998 and ...2002 in Slovenia, Russia, the Baltic States (Lithuania, Latvia, Estonia), Bulgaria, the Czech Republic, Poland, Slovakia and Hungary. A total of 466 patients with mild to moderately severe chronic obstructive pulmonary disease were treated with clarithromycin (Fromilid). The treatment was empirical, with an average duration of 8.1 days. Most of the patients (56%) were treated on an outpatient basis. The results of prospective clinical studies have demonstrated that 98% of the patients were either cured or their clinical picture improved significantly. Treatment success depended on the start of treatment with regard to onset of first signs of in fection (p<0.008) and the dose (p<0.05). In Slovenia, a prospective comparative multicentre clinical study was conducted as part of clinical studies of treatrnent of acute exacerbations of chronic bronchitis. The study comprised 78 patients from the University Clinic of Respiratory and Allergic Diseases Golnik and from the Maribor Teaching Hospital Department of Pulmology in Slivniško Pohorje. Treatment with clarithromycin (Fromilid) was more successful than treatment with the amoxicillin plus clavulanic acid combination. 538 patients with mild to moderately severe symptomatic x-ray-confirmed pneumonia were included in the clinical-acquired pneumonia with clarithromycin. 98% of patients were cured or their clinical picture was significantly improved. The treatment was more successful in patients with no underlying diseases (p<0.001). (Abstract trunacted at 2000 characters).
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