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  • Vloga statinov v preprečevanju srčno-žilnih bolezni = The role of statins in the prevention of cardiovascular diseases
    Reiner, Željko ; Tedeschi Reiner, Eugenia
    The HMG-CoA reductase inhibitors, often referred to as the statins, are inhibitors of cholesterol synthesis in hepatocytes. They are specific, competitive inhibitors of the enzyme HMG-CoA reductase, ... which catalyses the first step in cholesterol synthesis - the conversion of HMG-CoA to mevalonate.As a result, hepatic LDL-receptor activity increases, leading to increased uptake of LDL and decreased plasma total and LDL cholesterol. Several secondary prevention studies (4S, CARE, LIPID) in the last decade haveclearly demonstrated that secondary prevention of coronary heart disease (CHD) with statins should be essential treatment because it signi ficantly reduces cardiovascular morbidity and mortality and is cost-effective. There isincreasing evidence, particularly from primary prevention studies (WOSCOP, AFCAPS/TexCAPS), that statins should be used in primary prevention of CHD as well, especially for high risk patients. The greater is the total and LDL cholesterol reduction, the better is the risk lowering effect. However, the beneficial effects of statins should not only be attributed to their cholesterol-lowering effects. They also reduce the enhanced susceptibility to oxidation of LDL particles, restore endothelial dysfunction, prevent arterial smooth muscle cell migration and proliferation, reduce platelet aggregation, improve impaired fibrinolysis and stabilize the plaque. Apart from these antiatherogenic effects they seem to increase bone formation, thus possibly reducing the risk of osteoporotic fractures, and may inhibit tumour cell growth as well.
    Vir: Krka v medicini in farmaciji. - ISSN 0351-6040 (23, [št.] 33, 2002, str. 19-32)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - slovenski
    COBISS.SI-ID - 17815001

vir: Krka v medicini in farmaciji. - ISSN 0351-6040 (23, [št.] 33, 2002, str. 19-32)

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