Narodna in univerzitetna knjižnica, Ljubljana (NUK)
-
The use of model simplifications and scale-independent parameters for building a design space on the film coating process = Uporaba modelskih poenostavitev in od ravni neodvisnih spremenljivk pri postavitvi eksperimentalnega prostora za proces filmskega oblaganja tablet : doktorska disertacijaDebevec, VeronikaThe objective of the doctoral study was to develop scale-independent design space for the film coating process. We coated hygroscopic tablet cores with a moisture protective polyvinyl alcohol coating ... in order to protect the hydrolysable model drug substance from environmental moisture. Since we could not discover a universal approach for design space development, based on an overview of the current literature, we have outlined throughout this work, in our opinion, the most optimal approach: (1) We used scale-independent coating process parameters (product temperature, polymer dispersion droplet size and process relative humidity) as input variables for a face-centered central composite design. (2) We combined empirical as well as mechanistic modeling, and utilized model simplifications to quantitatively link the scale-independent parameters to scale-dependent ones (inlet air temperature, inlet air flow rate, inlet air humidity, coating dispersion spray rate, atomizing air pressure) in order to perform experiments. For elucidating the mechanisms, through which scale-independent parameters influence the product quality attributes, we selected the following responses: (1) The permeability of the film coating in order to assess film formation and consequently coating functionality in terms of moisture protection. (2) Water activity of film coated tablets (FCT) at the end of the spraying phase. Further, we correlated both responses with long-term stability results of FCT. Based on the obtained models and implementation of the proper constraints on responses, we determined a complete sequence of design spaces, connecting scale- independent spaces with scale-dependent ones. The main findings are the following: (1) Model simplifications and hybrid modeling can adequately describe the coating process and could be used for building a design space, which is independent of manufacturing scale.(2) With scale-independent design space in the coating process, it is possible to efficiently predict, control, and optimize the long-term stability of a moisture sensitive product. (3) During the film coating process, humidity conditions play the most important role in achieving product quality. However, the moisture protective coating itself has a negative influence on product stability for packaging configurations with a desiccant, due to keeping the moisture inside the FCT and preventing the desiccant from effectively drying out the FCT.Vrsta gradiva - disertacija ; neleposlovje za odrasleZaložništvo in izdelava - Ljubljana : [V. Debevec], 2021Jezik - angleškiCOBISS.SI-ID - 57124611
Povezava(-e):
Repozitorij Univerze v Ljubljani – RUL
Digitalna knjižnica Slovenije - dLib.siDostop z namenskih računalnikov v prostorih NUK
Avtor
Debevec, Veronika
Drugi avtorji
Srčič, Stanko |
Horvat, Matej, 1979-
Teme
Farmacevtska tehnologija |
tablete |
filmsko oblaganje |
vodna aktivnost tablet |
stabilnost izdelkov |
obložene tablete
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Rezervirajte gradivo na želenem mestu prevzema.
Mesto prevzema |
Status gradiva | Rezervacija |
---|---|---|
Časopisna čitalnica |
prosto - za čitalnico
|
|
Velika čitalnica |
prosto - za čitalnico
|
Signatura – lokacija, inventarna št. ... |
Status izvoda |
---|---|
GS II 0000740635 glavno skladišče GS II 740635 glavno skladišče |
prosto - za čitalnico
|
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Debevec, Veronika | 35859 |
Srčič, Stanko | 09031 |
Horvat, Matej, 1979- | 22306 |
Vir: Osebne bibliografije
in: SICRIS
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Naslov za dostavo:
Med podatki člana manjka naslov.
Storitev za pridobivanje naslova trenutno ni dostopna, prosimo, poskusite še enkrat.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in naslov za dostavo ter dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrani naslov za dostavo in dokončali postopek rezervacije.
Obvestilo
Trenutno je storitev za avtomatsko prijavo in rezervacijo nedostopna. Gradivo lahko rezervirate sami na portalu Biblos ali ponovno poskusite tukaj kasneje.
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Gradivo iz matične enote je brezplačno. Če je gradivo na mesto prevzema dostavljeno iz drugih enot, lahko knjižnica to storitev zaračuna.
Mesto prevzema | Status gradiva | Rezervacija |
---|
Rezervacija v teku
Prosimo, počakajte trenutek.
Rezervacija je uspela.
Rezervacija ni uspela.
Rezervacija...
Članska izkaznica:
Mesto prevzema:
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi