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  • Laparoscopy for diagnosis and treatment of severe Paecilomyces varioti peritonitis in a patient on continuous ambulatory peritoneal dialysis (CAPD) = Laparoskopija v diagnostiki in zdravljenju Paecilomyces varioti peritonitisa pri bolnici na peritonealni dializi
    Pleskovič, Alojz ; Bren, Andrej
    Paecilomyces varioti is a rare human pathogen. In the literature, solely nine cases of peritonitis in patients on CAPD have been described so far. We reporton severe peritonitis in a 53-year-old ... woman undergoing CAPD since November 1994. Paecilomyces varioti was isolated from the culture of peritoneal effluent. Intravenous (i. v.) therapy with amphotericin B 1 mg/kg was instituted and the peritoneal catheter was removed. Despite the therapy, the clinical and laboratory signs of inflammation persisted and the patient's mental status deteriorated. At laparoscopy diffuse white intraabdominal formations were noted. Three drainage catheters were inserted during the procedure. A 2.25% glucose solution containing amphotericin B in a concentration of 1 mg/L was used for perfusion of the abdominal cavity at a rate of of 300 ml/hour. The patient's mental status and laboratory signs of inflammation normalised rapidly. After twelve days of drainage we removed the catheters. As the patient's fungal cultures were negative, amphotericin was stopped and she was placed on long-term prophylactic antifungal therapy with intraconazole. In conclusion, i. v. administration of amphotericin B in a therapeutic dosage and simultaneous perfusion of the abdominal cavity with low-concentration amphotericin B has proved an effective modality for treatingsevere Paecilomyces varioti peritonitis. This approach to the treatment of severe fungal peritonitis has not yet been described in the literature.
    Vrsta gradiva - članek, sestavni del
    Leto - 1997
    Jezik - angleški
    COBISS.SI-ID - 7227353