Mediatorji eozinofilnega granulocita in astma = The mediators of the eosinophil granulocyte and asthma
Turel, Matjaž ; Šuškovič, Stanislav
Bacground. Asthma is a chronic inflammatory disorder of the airways in which many cells play a role, including eosinophils. In the systemic steroid dependent asthamics is the main goal to reduce ...steroid side effects with othereffectively anti-inflemmatory drug. Cyclosporine A is an immunosupresive drug with potentially beneficial effect on inflammated airways. The main goal of this study was to find out if low doses cyclosporin A in a one week treatment has an influence on serum eosinophils cation protein concentration and number of eosinophils in blood. Patients and methods. We treated one week 12 systemic steroid dependent asthmatics (group A) with cyclosporine A (2mgžkgžday), 8 asthmatics (the first control group) withouth regulary use of the systemic corticosteroids with 40 mg methylprednisolone daily (group B). 8 healthy atopics withouth asthma history (group C) was the second control group. In the groups A and B we have collected blood samples every four hours the day before and the last day of the treatment. We performed measurements inthe group C only one day. In the group A we registered at the same times blood concentration of the cyclosporine A. Results. In the group A did not significantly change the serum eosinophilic cation protein concentration and number of eosinophils. There were find no corelations between blood concentration of the cyclosporine A and serum eosinophilic cation protein concentration or number of eosinophils. In the group B we found statistically significant(p<0,05) differences in the serum eosinophilic cation protein (at $pm, 8 PM and 4 AM) and number of eosinophils (all samples) before and after the treatment with methylprendisolone. Conclusions. We conclude that short treatment with the low doses of the cyclosporine A did not have an important influence on the serum eosinophilic cation protein concentrations and number of eosinophils in blood. (Abstract truncated at 2000 characters)
Bibliografsko gradivo je bilo uspešno dodano na polico.
Dodajanje bibliografskega gradiva na polico ni uspelo.
Gradivo je že na polici.
Trajna povezava
URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto
Faktor vpliva
Izdaja
Kategorija
Razvrstitev
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Izberite knjižnično izkaznico:
Baze podatkov,
v katerih je revija indeksirana
Ime baze podatkov
Področje
Leto
Povezave do osebnih bibliografij avtorjev
Povezave do podatkov o raziskovalcih v sistemu SICRIS
Storitev za pridobivanje naslova trenutno ni dostopna, prosimo, poskusite še enkrat.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in naslov za dostavo ter dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrani naslov za dostavo in dokončali postopek rezervacije.
Obvestilo
Trenutno je storitev za avtomatsko prijavo in rezervacijo nedostopna. Gradivo lahko rezervirate sami na portalu Biblos ali ponovno poskusite tukaj kasneje.
Citiranje
Funkcionalnost trenutno ni na voljo. Prosimo, poskusite kasneje.
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi