1.
Extraoral vertical ramus osteotomy combined with internal fixation for the treatment of mandibular deformities
Öhrnell Malekzadeh, B.; Ivanoff, C.-J.; Westerlund, A. ...
British journal of oral & maxillofacial surgery,
02/2022, Letnik:
60, Številka:
2
Journal Article
Extraoral vertical ramus osteotomy (EVRO) is used in orthognathic surgery for the treatment of mandibular deformities. Originally, EVRO required postoperative intermaxillary fixation (IMF). EVRO has ...
been developed using rigid fixation, omitting postoperative IMF. We examined retrospectively the long-term stability and postoperative complications for patients with mandibular deformities who underwent EVRO with internal rigid fixation. Patients who were treated with EVRO for a mandibular deformity in the period 2008–2017 at the Clinic of Oral and Maxillofacial Surgery, Mölndal, Sweden were included (N = 26). Overjet and overbite were calculated digitally and cephalometric analyses were performed preoperatively, and at three days, six months, and 18 months postoperatively. There was a general setback of the mandible, decreased gonial angle and reduced degree of skeletal opening. Excellent dental and vertical skeletal stabilities were seen up to 18 months postoperatively, although relapse was seen sagitally up to six months postoperatively. Since the overjet did not show any significant change over time, the sagittal skeletal changes have been attributed to dental compensation. There was no permanent damage to the facial nerve and 5.8% neurosensory damage to the inferior alveolar nerve was observed.
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2.
Effects of locally administered insulin on bone formation in non-diabetic rats
Malekzadeh, B.; Tengvall, P.; Öhrnell, L.-O. ...
Journal of biomedical materials research. Part A,
01/2013, Letnik:
101A, Številka:
1
Journal Article
The possibility to control bone formation would be favorable in many areas of medicine, where bone defects is still a major challenge. Insulin has been suggested to exert both systemic and local ...
anabolic effects in bone tissues. This raised the question whether locally administrated insulin could provide new therapeutic strategies for patients with local bone defects and impaired bone healing. The aim of this study was to evaluate bone formation in non‐diabetic rats when local insulin is administered. This study differs from previous reports in two aspects: the use of non‐diabetic animals and locally administered insulin. Twenty‐four implants were inserted into 12 rats—one insulin‐coated and one control—in each tibia for four weeks. Interferometry and histomorphometry were used to evaluate the surface topography and bone formation, respectively. Results demonstrated no significant changes in surface topography after insulin immobilization. Histomorphometry revealed significantly more bone around the insulin‐coated implants (BA) (p = 0.005) and a similar amount of bone at the implant surface (BIC) (p = 0.117) compared with the controls. It was concluded that locally administered insulin from a titanium implant surface has the potential to increase bone formation not only in diabetic subjects but also in non‐diabetic subjects. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A:132–137, 2013.
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3.
Insulin released from titanium discs with insulin coatings-Kinetics and biological activity
Malekzadeh, B Ö; Ransjo, M; Tengvall, P ...
Journal of biomedical materials research. Part B, Applied biomaterials,
10/2017, Letnik:
105, Številka:
7
Journal Article
Local administration of insulin from a titanium surface has been demonstrated to increase bone formation in non-diabetic rats. The authors hypothesized that insulin was released from the titanium ...
surface and with preserved biological activity after the release. Thus, in the present in vitro study, human recombinant insulin was immobilized onto titanium discs, and the insulin release kinetics was evaluated using Electro-chemiluminescence immunoassay. Neutral Red uptake assay and mineralization assay were used to evaluate the biological effects of the released insulin on human osteoblast-like MG-63 cells. The results confirmed that insulin was released from titanium surfaces during a six-week period. Etching the disc prior to insulin coating, thickening of the insulin coating and incubation of the discs in serum-enriched cell culture medium increased the release. However, longer storage time decreased the release of insulin. Furthermore, the released insulin had retained its biological activity, as demonstrated by the significant increase in cell number and a stimulated mineralization process, upon exposure to released insulin. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1847-1854, 2017.
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4.
Effects of implant‐delivered insulin on bone formation in osteoporotic rats
Malekzadeh, Behnosh Ö.; Erlandsson, Malin C.; Tengvall, Pentti ...
Journal of biomedical materials research. Part A,
September 2018, Letnik:
106, Številka:
9
Journal Article
Osteoporosis is a major cause of age‐related fractures. Healing complications in osteoporotic patients are often associated with increased mortality and morbidity. Stimulation of the implant‐adjacent ...
bone could be beneficial in terms of the surgical outcome. Over the past decade, numerous investigations have implicated insulin in normal bone growth, and recent studies have described the advantages of administering insulin locally to increase bone formation. Therefore, we hypothesized that insulin‐coated titanium implants would increase bone formation in osteoporotic animals. The aim of this study was to evaluate the effects of insulin delivered from an implant surface on bone‐related gene expression and bone formation in osteoporotic rats. Characterizations of the surfaces of insulin‐coated and control implants were performed using ellipsometry and interferometry. Forty ovariectomized and four healthy Sprague Dawley rats were used and implants were inserted in the tibias. The systemic effect of insulin was assessed by measuring the blood glucose levels and total body weight. The animals were sacrificed either 1 day or 3 weeks postimplantation. Implant‐adherent cells were analyzed by quantitative real‐time PCR, and the bone adjacent to the implants was examined by microcomputed tomography and histomorphometry. The insulin‐coated implants had no systemic effects. The insulin‐coated samples demonstrated significantly lower expression of the gene for interleukin 1β (p = 0.019) at 1 day, and significantly exhibited more periosteal callus (p = 0.029) at 3 weeks. Locally delivered insulin has potential for promoting bone formation and it exerts potentially anti‐inflammatory effects in osteoporotic rats. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A:2472–2480, 2018.
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