Climate change is one of the main threats to biodiversity in the 21st century. However, the effects that it may have on different mammal species are unknown, making it difficult to implement ...conservation strategies. In this paper, we used species distribution models (SDM) to assess the effect of global climate change on the potential distribution of the 8 of the 9 marsupial species in Mexico, and analyzed their distribution in the current system of natural protected areas (NPAs). We used presence records for each species and bioclimatic variables from the present and the future (2050 and 2080) with 2 contrasting possible scenarios (representative concentration pathways RCP 4.5 and 8.5). We found that Tlacuatzin canescens would have the most stable potential range under any climate change scenario, while the remaining species (Caluromys derbianus, Chironectes minimus, Didelphis marsupialis, D. virginiana, Philander opossum, Marmosa mexicana, and Metachirus nudicaudatus) would undergo notable range losses in the future, though there would not only be losses—according to our SDMs, for all species there would be some range gain under the different climate scenarios, assuming the vegetation cover remained. The current system of NPAs in Mexico currently protects and under the 2 future scenarios would protect less than 20% of the potential range of marsupials, so a reevaluation of their areas beyond the NPAs is highly recommended for the long-term conservation of this group. Our results provide relevant information on the estimated effects of global climate change on marsupials, allowing us to design more effective methodologies for the protection of this portion of the mammalian fauna in Mexico. El cambio climático es una de las principales amenazas a la biodiversidad en el siglo XXI. Sin embargo, se desconocen los efectos que pueda tener sobre las diferentes especies de mamíferos, dificultando la implementación de estrategias para su conservación. En este estudio, empleamos Modelos de Distribución de Especies (SDM) para evaluar el efecto del cambio climático global sobre la distribución potencial de ocho de las nueve especies de marsupiales registradas en México, analizando además su distribución en el actual sistema de Áreas Naturales Protegidas (ANP). Utilizamos registros de presencia de cada especie y variables bioclimáticas del presente y del futuro (2050 y 2080) con dos escenarios contrastantes (RCP 4.5 y RCP 8.5). Encontramos que Tlacuatzin canescens mostrará el área de distribución potencial más estable ante cualquier escenario de cambio climático. Por el contrario, el resto de las especies (Caluromys derbianus, Chironectes minimus, Didelphis marsupialis, Didelphis virginiana, Philander opossum, Marmosa mexicana y Metachirus nudicaudatus) presentarán notables pérdidas de área de distribución en el futuro. Sin embargo, también encontramos que no sólo habrá pérdidas, ya que de acuerdo con nuestros SDM todas las especies mostrarán cierta ganancia de área de distribución bajo los diferentes escenarios climáticos, en el supuesto de que permanezca la cubierta vegetal. El actual sistema de ANP en México protege y, bajo los dos escenarios futuros, protegerá menos del 20% del área de distribución potencial de los marsupiales, por lo que es altamente recomendable reevaluar sus áreas de extensión para la conservación de este grupo a largo plazo. Nuestros resultados proporcionan información relevante de los efectos probables del cambio climático sobre los marsupiales, lo que permite generar metodologías más efectivas para la protección de los mamíferos en México.
Little is known about employee reactions in the form of un/ethical behavior to perceived acts of unfairness toward their peers perpetrated by the supervisor. Based on prior work suggesting that third ...parties also make fairness judgments and respond to the way employees are treated, this study first suggests that perceptions of interactional justice for peers (IJP) lead employees to two different responses to injustice at work: deviant workplace behaviors (DWBs) and organizational citizenship behaviors (OCBs). Second, based on prior literature pointing to supervisors as among the most important sources of moral guidance at work, a mediating role is proposed for ethical leadership. The article suggests that supervisors who inflict acts of injustice on staff will be perceived as unethical leaders, and that these perceptions would explain why employees react to IJP in the form of deviance (DWBs) and citizenship (OCBs). Data were collected from 204 hotel employees. Results of structural equation modeling demonstrate that DWBs and OCBs are substantive reactions to IJP, whereas ethical leadership significantly mediates reactions in the form of DWBs and OCBs. Behavioral ethics and managerial implications are discussed.
Alzheimer’s disease (AD), the most common neurodegenerative disease and the first cause of dementia worldwide, has no effective treatment, and its pathological mechanisms are not yet fully ...understood. We conducted this study to explore the proteomic differences associated with Familial Alzheimer’s Disease (FAD) in olfactory ecto-mesenchymal stem cells (MSCs) derived from PSEN1 (A431E) mutation carriers compared with healthy donors paired by age and gender through two label-free liquid chromatography-mass spectrometry approaches. The first analysis compared carrier 1 (patient with symptoms, P1) and its control (healthy donor, C1), and the second compared carrier 2 (patient with pre-symptoms, P2) with its respective control cells (C2) to evaluate whether the protein alterations presented in the symptomatic carrier were also present in the pre-symptom stages. Finally, we analyzed the differentially expressed proteins (DEPs) for biological and functional enrichment. These proteins showed impaired expression in a stage-dependent manner and are involved in energy metabolism, vesicle transport, actin cytoskeleton, cell proliferation, and proteostasis pathways, in line with previous AD reports. Our study is the first to conduct a proteomic analysis of MSCs from the Jalisco FAD patients in two stages of the disease (symptomatic and presymptomatic), showing these cells as a new and excellent in vitro model for future AD studies.
In the United States, Black and Latinx youth remain disproportionately affected by HIV. Oral antiretroviral pre-exposure prophylaxis (PrEP) is a proven effective HIV prevention strategy. PrEP is ...approved for use in people younger than the age of 18 years, but little is known about provider comfort and preparedness with prescribing it to adolescents. In this study, physicians provide their perspectives on the facilitators and barriers to PrEP access among adolescents. Focus groups (
= 23) were conducted with pediatric and family practitioners practicing in an urban community hospital setting to assess PrEP awareness and receptivity to use among adolescents. Most providers were unfamiliar with clinical guidelines for PrEP use, especially in determining adolescent candidates for PrEP use, including appropriate dosing regimen and follow-up procedures. Overall, providers had low intent on prescribing PrEP, citing concerns about consent, medication adherence, and appropriateness of primary care providers in prescribing and managing adolescent PrEP use. Strategies that will address provider education and comfort in prescribing PrEP to adolescents are required to increase PrEP access and uptake among communities disproportionally affected by HIV.
Dust sources have been revealed through remote sensing, first regionally by ~1° resolution sensors (TOMS), then at sub-basin scale by moderate-resolution sensors (MODIS). Sensors with higher spatial ...resolution until recently were poorly temporally-resolved, precluding their use for systematic investigations of sources. Now, “CubeSat” constellations with high-temporal-and-spatial-resolution sensors such as PlanetScope offer ~3 m resolution and daily (to sub-daily) temporal resolution. We illustrate the spatio-temporal dust plume observation capabilities of CubeSat data through a dust event case study, Bolson de los Muertos playa, Chihuahuan Desert, Mexico. For the event, PlanetScope showed numerous discrete point sources, revealing variability of surface erodibility and emission over ~8% of a focus area at time of capture. The unprecedented detail of PlanetScope imagery revealed plume development where outer-playa sands and fluvial-deltaic inputs contact lacustrine silts/clays, consistent with field-studies. PlanetScope's high fidelity improves spatial quantification and temporal constraint of source activity, and we assess the spatio-temporal capabilities of CubeSat in context with other dust observation remote sensing systems. Compared to previous satellite technologies, CubeSats bring better potential to link remote sensing to field observations of emission. This leap forward in the remote sensing of dust sources calls for the systematic analysis of CubeSat imagery in source areas.
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•Remote sensing has enabled key characterisations of mineral dust sources globally.•Moderate-resolution sensors cannot be reconciled with field study of dust emission.•New CubeSat technology allows observation of active emission processes.•Potential for sub-daily source monitoring from sensors in constellations.•We call for the systematic application of CubeSat imagery over dust sources.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the predominant form of dementia globally. No reliable diagnostic, predictive techniques, or curative interventions are ...available. MicroRNAs (miRNAs) are vital to controlling gene expression, making them valuable biomarkers for diagnosis and prognosis. This study examines the transcriptome of olfactory ecto-mesenchymal stem cells (MSCs) derived from individuals with the PSEN1(A431E) mutation (Jalisco mutation). The aim is to determine whether this mutation affects the transcriptome and expression profile of miRNAs and their target genes at different stages of asymptomatic, presymptomatic, and symptomatic conditions. Expression microarrays compare the MSCs from mutation carriers with those from healthy donors. The results indicate a distinct variation in the expression of miRNAs and mRNAs among different symptomatologic groups and between individuals with the mutation. Using bioinformatics tools allows us to identify target genes for miRNAs, which in turn affect various biological processes and pathways. These include the cell cycle, senescence, transcription, and pathways involved in regulating the pluripotency of stem cells. These processes are closely linked to inter- and intracellular communication, vital for cellular functioning. These findings can enhance our comprehension and monitoring of the disease's physiological processes, identify new disorder indicators, and develop innovative treatments and diagnostic tools for preventing or treating AD.
The Samalayuca Dunes (SMD) (Médanos de Samalayuca), Chihuahua, México, are one of México’s largest and least studied dune fields, now managed as a Protected Area for their ecological characteristics. ...We present a morphometric characterization of the dune field based on remote sensing and field studies, to advance understanding of its physical environment. SMD’s generally-fine sands originate from shoreline deposits of Paleolake Palomas, transported eastward (downwind) along an aeolian corridor, accumulating primarily as echo dunes upwind of the sierras of Samalayuca and Presidio. A complex wind regime, with northerly and southerly winds complementing regionally-prevailing southwesterlies, modified by topographic effects, shapes the SMD’s morphology. The sand sea covers ~139.7 km2, with ~113.8 km2 in the main eastern body and ~25.9 km2 in a northwestern subfield. We describe six major dune forms: north to south straight-crested dunes, east to west straight-crested dunes, star dunes, vegetated parabolic dunes, relict transverse dunes, and “megastar” (draa) dunes. Mean interdune centroid spacing is 76.5 m. The active dunes, previously described as an “aklé” pattern, are predominantly straight-crested dune sets oriented near-perpendicular to each other with general north-south and east-west crest orientations, 4-5 m high, spaced ~67 m apart for north-south trending crests and ~53 m for east-west trending crests, representing a nearly perpendicular interference pattern in some locations. The active dunes are superimposed in a compound and complex arrangement on relict remnants of much larger north-northwest trending transverse dune ridges fanning out from south to north-northwest, spaced approximately ~1 km apart and ~50 m high. The easternmost dune ridge contains an active set of at least 15 active megastar and reversing dunes up to 120 m tall, increasing in size and complexity from south to north. As a protected area with historical and ecological value, additional geologic investigations should be performed at the SMD, to help conserve this remarkable geologic feature.
Mesenchymal stem cells (MSCs) are self-renewing cells found in almost all postnatal organs and tissues in the perivascular region. These cells have a high capacity for mesodermal differentiation; ...however, numerous studies have shown that MSCs can also differentiate into cells of endodermal and ectodermal lineages. Due to this multilineage differentiation capacity, these cells could function as restoratives of various cell populations after transplantation. However, not only their differentiation potential makes them ideal candidates for this, but also a series of trophic properties that promote regeneration in the surrounding tissue, such as their migratory capacity, secretory and immunomodulatory actions. This review analyzes several MSC transplantation trials to treat neurological diseases, such as demyelinating injury, spinal cord injury, paraplegia, Parkinson's disease, cochlear injury, and Alzheimer's disease. These cells could facilitate functional recovery in multiple models of neurodegenerative diseases and nervous system injuries by using their trophic capacities, reducing inflammation in the injured area, reducing apoptosis, and enhancing endogenous neurogenesis through the secretion of bioactive factors. Furthermore, since cells derived from patients have demonstrated disease-associated differences in various brain diseases, these cells represent an excellent candidate for the study of these diseases, functioning as "a window to the brain."
Intimate partner violence against women (IPVAW) is a public health problem that affects women worldwide. Consequently, victims frequently go to healthcare centers, usually with a cover reason. To ...address this problem, national and autonomic protocols to respond to IPVAW in health systems have been developed in Spain. In this regard, the role of primary care physicians (PCPs) will be essential for addressing IPVAW, but they could encounter obstacles in doing so. The purpose of this study was to explore how IPVAW is addressed in healthcare centers in Spain. This study synthesized the information available in the protocols to address IPVAW among health care workers in Spain and analyzed it according to World Health Organization (WHO) guidelines. Additionally, PCPs’ perspectives on these protocols and the nature of IPVAW attention from healthcare centers were explored through a focus group. The findings displayed that, although the protocols mostly conform to WHO guidelines, they are insufficient to address IPVAW. Generally, PCPs were unaware of the existence of the protocols and referred to the lack of training in IPVAW and protocol use as one of the main obstacles to intervening, along with a lack of time and feelings as well as cultural, educational, and political factors. The adoption of measures to ensure that PCPs apply these protocols correctly and to approach PCPs’ obstacles for addressing IPVAW in consultations will be crucial for the care of victims.
This study models guests' reactions to a hotel based on the way they perceive management's treatment of staff. First, it is suggested that guests empathize with staff by placing themselves in the ...staff member's position, and that customers who perceive unfair treatment of staff show decreased loyalty and increased dysfunctional behavior. Second, treatment considered unfair is internalized by guests, thus leading guests who also perceive themselves as victims of unfair treatment to identify even more with hotel staff. Data were collected from 343 guests in seven sampled hotels in the Canary Islands (Spain). Results of hierarchical multiple regressions demonstrate that only reduced loyalty is a substantive reaction to perceived injustice toward employees, whereas engaging in disloyal and dysfunctional behavior are significant reactions to perceived mistreatment of self. These effects on dysfunctional behavior are also found to be intensified among guests who perceive management's mistreatment of them and staff members, and stay in an all-inclusive package situation. Managerial implications of these findings are discussed.
► Alleged mistreatment of staff and guests is examined. ► Guests show signs of reduced loyalty when perceiving acts of injustice to staff. ► Dysfunctional behavior is activated among guests who perceive mistreatment of themselves and staff. ► These effects are also intensified where a guest stays on an all-inclusive package.
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