Coronavirus disease 2019 (COVID‐19) has had different waves within the same country. The spread rate and severity showed different properties within the COVID‐19 different waves. The present work ...aims to compare the spread and the severity of the different waves using the available data of confirmed COVID‐19 cases and death cases. Real‐data sets collected from the Johns Hopkins University Center for Systems Science were used to perform a comparative study between COVID‐19 different waves in 12 countries with the highest total performed tests for severe acute respiratory syndrome coronavirus 2 detection in the world (Italy, Brazil, Japan, Germany, Spain, India, USA, UAE, Poland, Colombia, Turkey, and Switzerland). The total number of confirmed cases and death cases in different waves of COVID‐19 were compared to that of the previous one for equivalent periods. The total number of death cases in each wave was presented as a percentage of the total number of confirmed cases for the same periods. In all the selected 12 countries, Wave 2 had a much higher number of confirmed cases than that in Wave 1. However, the death cases increase was not comparable with that of the confirmed cases to the extent that some countries had lower death cases than in Wave 1, UAE, and Spain. The death cases as a percentage of the total number of confirmed cases in Wave 1 were much higher than that in Wave 2. Some countries have had Waves 3 and 4. Waves 3 and 4 have had lower confirmed cases than Wave 2, however, the death cases were variable in different countries. The death cases in Waves 3 and 4 were similar to or higher than Wave 2 in most countries. Wave 2 of COVID‐19 had a much higher spread rate but much lower severity resulting in a lower death rate in Wave 2 compared with that of the first wave. Waves 3 and 4 have had lower confirmed cases than Wave 2; that could be due to the presence of appropriate treatment and vaccination. However, that was not reflected in the death cases, which were similar to or higher than Wave 2 in most countries. Further studies are needed to explain these findings.
Diabetes is a known risk factor for sexual dysfunction in men; diabetic men have an increased risk of erectile dysfunction compared to non‐diabetic men. Canagliflozin is one of the common ...antidiabetic drugs that is readily used in the treatment of type‐2 diabetes. Concomitantly phosphodiesterase 5 inhibitors, such as tadalafil, can be given to the patient to alleviate erectile dysfunction. Canagliflozin is reported to be one of the cytochrome P450 3A4 enzyme inhibitors, that might seriously influence blood concentration levels of tadalafil but there is no study till now, discussing this interaction. Therefore, a fast, simple, and sensitive high‐performance thin‐layer chromatographic method was developed, validated, and applied for the simultaneous determination of tadalafil and canagliflozin in spiked and real human plasma. The limit of detection for tadalafil was 0.14 ng/band and for canagliflozin was 0.16 ng/band. The limit of quantitation value for tadalafil was 0.43 ng/band and for canagliflozin was 0.47 ng/band. Tadalafil and canagliflozin were determined simultaneously in real human plasma using the described procedure and the method was applied for in vivo pharmacokinetic drug interaction study between the studied drugs, which proved significant interaction between them when administered simultaneously.
Objective
To determine prognostic value of bone marrow retention index (RI-bm) and bone marrow-to-liver ratio (BLR) measured on baseline dual-phase
18
F-FDG PET/CT in a series of newly diagnosed ...patients with diffuse large B-cell lymphoma (DLBCL) treated homogeneously with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy.
Patients and methods
This prospective study enrolled 135 patients with newly diagnosed DLBCL. All patients underwent dual-phase
18
F-FDG PET/CT. The following PET parameters were calculated for both tumor and bone marrow: maximum standardized uptake value (SUVmax) at both time points (SUVmax early and SUVmax delayed), SUVmax increment (SUVinc), RI, and BLR. Patients were treated with R-CHOP regimen and response at end of treatment was assessed.
Results
The final analysis included 98 patients with complete remission. At a median follow-up of 22 months, 57 patients showed no relapse, 74 survived, and 24 died. The 2-year relapse-free survival (RFS) values for patients with higher and lower RI-bm were 20% and 65.1%, respectively (p < 0.001), and for patients with higher and lower BLR were 30.2% and 69.6%, respectively (
p
< 0.001). The 2-year overall survival (OS) values for patients with higher and lower RI-bm were 60% and 76.3%, respectively (
p
= 0.023), and for patients with higher and lower BLR were 57.3% and 78.6%, respectively (p = 0.035). Univariate analysis revealed that RI-bm and BLR were independent significant prognostic factors for both RFS and OS (hazard ratio HR = 4.02,
p
< 0.001, and HR = 3.23,
p
< 0.001, respectively) and (HR = 2.83,
p
= 0.030 and HR = 2.38,
p
= 0.041, respectively).
Conclusion
Baseline RI-bm and BLR were strong independent prognostic factors in DLBCL patients.
Clinical relevance statement
Bone marrow retention index (RI-bm) and bone marrow-to-liver ratio (BLR) could represent suitable and noninvasive positron emission tomography/computed tomography (PET/CT) parameters for predicting pretreatment risk in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) who were treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy.
Key Points
•
Bone marrow retention index (RI-bm) and bone marrow-to-liver ratio (BLR) are powerful prognostic variables in diffuse large B-cell lymphoma (DLBCL) patients
.
•
High BLR and RI-bm are significantly associated with poor overall survival (OS) and relapse-free survival (RFS)
.
•
RI-bm and BLR represent suitable and noninvasive risk indicators in DLBCL patients
.
Potato plants and their tubers in Egypt are affected by one of the most renowned soil-borne pathogen, Ralstonia solanacearum, that caused brown rot in potato tubers and wilt in plants. There is no ...efficient therapeutic bactericide so; control of bacterial wilt is very rough.
The study investigated three different concentrations of seven essential plant oils under in vitro and in vivo conditions as a result of their effects on Ralstonia solanacearum growth and their possibility use as potato seed pieces dressing for controlling bacterial wilt disease incidence. In vitro, anise oil at the three tested different concentrations (0.04, 0.07, and 0.14% vol/vol) was the most effective one inhibiting the growth of T4 and W9 isolates of Ralstonia solanacearum then pursued by thyme, lemongrass, and clove oils. On the other hand, rocket oil at the tested concentration was the least effective one followed by fennel oil. However, wheat germ oil was not completely effective. In vivo, experiment revealed that anise oil at the three concentrations significantly reduced disease incidence and severity in sponta and hermes potato cultivars and their effect was associated with increase of peroxidase, polyphenoloxidase, phenols and the foliar fresh weight of treated plants as well as the weight of tubers/plant followed by thyme and lemongrass oils compared to the infected untreated control.
Morphological differences in bacterial cell structure have been observed using a transmission electron microscope (TEM). Anise oil at higher concentration caused of cell wall rupture and degraded cellular components.
To compare safety and efficacy of combined therapy with conventional transarterial chemoembolization (cTACE)+microwave ablation (MWA) versus only TACE or MWA for treatment of hepatocellular carcinoma ...(HCC) >3-<5 cm.
This randomized controlled trial (NCT04721470) screened 278 patients with HCC >3-<5 cm. Patients were randomized into three groups: 90 underwent TACE (Group 1); 95 underwent MWA (Group 2); and 93 underwent combined therapy (Group 3). Patients were followed-up with contrast-enhanced CT or MRI. Images were evaluated and compared for treatment response and adverse events based on modified response evaluation criteria in solid tumor. Serum alpha-fetoprotein (AFP) concentration was measured at baseline and during every follow-up visit.
Final analysis included 265 patients (154 men, 111 women; mean age = 54.5 ± 11.8 years; range = 38-76 years). Complete response was achieved by 86.5% of patients who received combined therapy compared with 54.8% with only TACE and 56.5% with only MWA (p = 0.0002). The recurrence rate after 12 months was significantly lower in Group 3 (22.47%) than Groups 1 (60.7%) and 2 (51.1%) (p = 0.0001). The overall survival rate (three years after therapy) was significantly higher in Group 3 (69.6%) than Groups 1 (54.7%) and 2 (54.3%) (p = 0.02). The mean progression-free survival was significantly higher in Group 3 than groups 1 and 2 (p < 0.001). A decrease in AFP concentration was seen in 75%, 63%, and 48% patients of Group 3, 2, and 1, respectively.
Combined therapy with cTACE + MWA is safe, well-tolerated, and more effective than TACE or MWA alone for treatment of HCC >3-<5 cm.
•The effect of heptanol/diesel blends on diesel engine combustion is tested.•The BTE were increased when higher alcohol/diesel blends were used.•Higher alcohols have long ignition delay and the ...longest was for But10 and But20.•The highest combustion efficiency was achieved for Hept20.•The NOx and soot were reduced but CO and HC were increased for higher alcohol blends.
As there were limited efforts towards the substitution of diesel fuel with higher alcohols to operate diesel engine, the current work aims to evaluate diesel engine performance at wide operating conditions fuelled by blends of higher alcohols; including heptanol and octanol. To increase the trust of the received results, blends of lower alcohols (butanol) was studied where the attained results showed good agreement with those cited in the literature. Single-cylinder diesel engine setup equipped with the necessary sensors for measuring cylinder pressure, engine speed, output power, air flow rate, fuel flow rate and temperature at various locations in engine was used to realize the current objective. The study limits the blending ratios to be 10% and 20% v/v to keep the fuel system without any modifications. These blends showed stable and homogenous features for period of four months without phase separation. The steady state experiments were carried out at various engine loads (0%, 25%, 50% and 75% of the full load) and engine speeds (900 rpm and 1500 rpm). Results revealed that bsfc and BTE increased almost for all tested higher alcohol/diesel blends. The ignition delay increased with higher alcohols/diesel blends and the longest value was achieved by But10 and But20. The premixed combustion was enhanced for all tested higher alcohol/diesel blends. The highest cumulative net heat released was achieved for Hept20. The emissions of NOx and opacity were reduced while those of CO and HC emissions were increased for all tested higher alcohol/diesel blends compared to the corresponding values for D100.
Abstract Background Although a clear mechanism underlying the pathophysiology of schizophrenia (SZ) remains elusive, oxidative stress, inflammatory syndrome and immune activation have become an ...attractive hypothesis for explaining the pathophysiology of SZ. Data from prior studies on the role of matrix metalloproteinase 9 (MMP-9) and brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms (SNPs) in SZ are contradictory. We aimed to investigate whether oxidative stress, inflammatory and immune activation markers as well as MMP-9 levels may be implicated in SZ pathogenesis. The association of MMP-9 and BDNF SNPs with the clinical expression of SZ was examined. Subjects and methods Ninety-four subjects were recruited, including 44 SZ patients and 50 healthy controls. Serum levels of thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCC), nitrite, C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), Beta-2 microglobulin (Β2M), complement component 3 (C3), C4 and MMP-9 were measured. The MMP-9 − 1562C > T and BDNF196G > A SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism assay. Psychopathology was assessed using the positive and negative syndrome scale (PANSS). Results SZ patients showed significantly higher TBARS, PCC, nitrite, CRP, IL-6, TNF-α, Β2M, C3 and MMP-9 levels than controls. In distinguishing SZ patients from healthy controls, CRP and MMP-9 yielded similar discriminatory performance, and both perform better than IL-6, Β2M, C3, nitrite, TBARS, PCC, TNF-α and C4. The MMP-9 − 1562C > T SNP genotypes distribution didn't differ significantly between controls and SZ patients. As compared to controls, SZ patients harbor a significantly higher frequency of the BDNF196GG genotype and a lower frequency of the BDNF196GA/AA genotype. Patients carrying the MMP-9 − 1562CC or BDNF196GG genotype revealed a significantly higher PANSS than those carrying MMP-9 − 1562CT/TT or BDNF196GA/AA genotype. Male gender and the MMP-9 − 1562CC genotype were identified as independent predictive factors for higher PANSS. Conclusions Redox dysregulation and alterations in the immuno-inflammatory pathways are major culprits in the pathogenesis of SZ. MMP-9 and BDNF SNPs are associated with the clinical phenotype of SZ and, thus, may be a useful marker predicting the phenotypic expression and prognosis of SZ patients.
Purpose
To compare effectiveness of three widely used embolic agents in partial splenic embolization (PSE) by analyzing their clinical, laboratory, and radiological outcomes within one year of ...follow-up.
Materials and methods
This retrospective study examined 179 patients who underwent PSE to manage hypersplenism secondary to cirrhosis. Patients were divided into 3 groups according to embolic agent used. Group 1 (gelatin sponge) included 65 patients, group 2 (embospheres) included 58 patients, and group 3 (PVA) included 56 patients. Clinical, laboratory, and radiological outcomes were compared between groups.
Results
The technical success rate was 100% in all groups. Pain as a major complication was lower in the gelatin sponge group (20%) compared to the embosphere group (31%) and PVA group (32.3%). Major complications other than pain were found in 20.1%; 24.6% in gelatin sponge group, 15.5% in embosphere group and 19.6% in PVA group (
p
= 0.045). WBCs and platelet counts showed a significant increase after PSE in all groups. Entire splenic volume as measured by computed tomography after PSE showed no significant difference among the 3 groups; however, the volume of infarcted spleen was significantly lower in the gelatin sponge group compared to other two groups (
p
= 0.001). The splenic span was significantly reduced one-year post-procedure in three groups (
p
= 0.006), and it was significantly less in embosphere and PVA groups compared to gelatin sponge group (
p
< 0.05). Recurrent bleeding was higher in gelatin sponge group (
p
< 0.05).
Conclusions
Permanent embolic materials achieved better laboratory and radiological outcomes than gelatin sponge particles in PSE of cirrhotic hypersplenism patients. However, permanent particles were associated with greater abdominal pain.
The sun is considered as the most promising abundant renewable energy source that can be exploited to solve many of human beings’ challenges such as energy and water scarcity. Solar energy can be ...utilized in steam and vapor generation processes which has a great importance in many engineering applications such as water desalination, domestic water heating, and power generation. However, dilute solar flux (∼1000 W/m2) cannot supply the absorber with enough power required to overcome water latent heat of vaporization to evaporate water. Optical concentrators such as parabolic trough collector, parabolic dish reflector, and circular Fresnel lens can be used to concentrate the solar radiation to achieve the required power however they suffer from complexity and high cost. Moreover, the efficiency of the conventional solar desalination devices such as solar stills decreases dramatically with increasing bulk water quantity, due to the heat loss to bulk water. Therefore, the need to solar steam generation (SG) devices, that localize heating on a thin layer of water rather than the water bulk, arises. Thin film technology has shown promising progress in SG in which solar energy is utilized to wastewater desalination. The past five years have seen a significant surge in the development of thin film based SG devices. In this review, recently developed thin film-based SG devices are scrutinized with respect to their physical mechanisms, fabrication methods, structure, advantages, and disadvantages. Different types of thin-film materials, including: metal-based nanoparticles, metal oxides, carbon-based materials, polymers, etc.; as well as different substrates materials, including: wood, paper, cotton fabric, carbon fabric, polystyrene foam, and gauze, have been discussed. Moreover, different preparation and synthetization methods of the steam generation devices have been discussed. Suggestions for future research directions are also presented.
Water shortage is a major environmental stress that destructively impacts maize production, particularly in arid regions. Therefore, improving irrigation management and increasing productivity per ...unit of water applied are needed, especially under the rising temperature and precipitation fluctuations induced by climate change. Laboratory and field trials were carried out in the present study, which were aimed at assessing the possibility of promoting maize germination, growth, grain yield and crop water productivity (CWP) using seed priming under different irrigation regimes. Two seed priming treatments, i.e., hydro-priming and hardening versus unprimed seeds, were applied under four irrigation regimes, i.e., 120, 100, 80 and 60% of estimated crop evapotranspiration (ETc). The obtained results indicated that increasing irrigation water from 100% up to 120% ETc did not significantly increase grain yield or contributing traits, while it decreased CWP. Deficit irrigation of 80 and 60% ETc gradually decreased grain yield and all attributed traits. Seed priming significantly ameliorated seedlings’ vigor as indicated by earlier germination, higher germination percentage, longer roots and shoots, and heavier fresh and dry weight than unprimed seeds with the superiority of hardening treatment. Additionally, under field conditions, seed priming significantly increased grain yield, yield contributing traits and CWP compared with unprimed treatment. Interestingly, the results reflect the role of seed priming, particularly hardening, in mitigating negative impacts of drought stress and enhancing maize growth, grain yield and attributed traits as well as CWP under deficit irrigation conditions. This was demonstrated by a significant increase in grain yield and CWP under moderate drought and severe drought conditions compared with unprimed treatment. These results highlight that efficient irrigation management and seed priming can increase maize yield and water productivity in arid environments.
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