To perform a systematic review of studies using remote physical activity monitoring in neurological diseases, highlighting advances and determining gaps.
Studies were systematically identified in ...PubMed/MEDLINE, CINAHL and SCOPUS from January 2004 to December 2014 that monitored physical activity for ≥24 hours in adults with neurological diseases. Studies that measured only involuntary motor activity (tremor, seizures), energy expenditure or sleep were excluded. Feasibility, findings, and protocols were examined.
137 studies met inclusion criteria in multiple sclerosis (MS) (61 studies); stroke (41); Parkinson's Disease (PD) (20); dementia (11); traumatic brain injury (2) and ataxia (1). Physical activity levels measured by remote monitoring are consistently low in people with MS, stroke and dementia, and patterns of physical activity are altered in PD. In MS, decreased ambulatory activity assessed via remote monitoring is associated with greater disability and lower quality of life. In stroke, remote measures of upper limb function and ambulation are associated with functional recovery following rehabilitation and goal-directed interventions. In PD, remote monitoring may help to predict falls. In dementia, remote physical activity measures correlate with disease severity and can detect wandering.
These studies show that remote physical activity monitoring is feasible in neurological diseases, including in people with moderate to severe neurological disability. Remote monitoring can be a psychometrically sound and responsive way to assess physical activity in neurological disease. Further research is needed to ensure these tools provide meaningful information in the context of specific neurological disorders and patterns of neurological disability.
The nature and origin of the cold interstellar medium (ISM) in early-type galaxies are still a matter of debate, and understanding the role of this component in galaxy evolution and in fuelling the ...central supermassive black holes requires more observational constraints. Here, we present a multiwavelength study of the ISM in eight nearby, X-ray and optically bright, giant elliptical galaxies, all central dominant members of relatively low-mass groups. Using far-infrared spectral imaging with the Herschel Photodetector Array Camera & Spectrometer, we map the emission of cold gas in the cooling lines of C iiλ157 μm, O i λ63 μm and O ib λ145 μm. Additionally, we present Hα+N ii imaging of warm ionized gas with the Southern Astrophysical Research (SOAR) telescope, and a study of the thermodynamic structure of the hot X-ray emitting plasma with Chandra. All systems with extended Hα emission in our sample (6/8 galaxies) display significant C ii line emission indicating the presence of reservoirs of cold gas. This emission is cospatial with the optical Hα+N ii emitting nebulae and the lowest entropy soft X-ray emitting plasma. The entropy profiles of the hot galactic atmospheres show a clear dichotomy, with the systems displaying extended emission-line nebulae having lower entropies beyond r 1 kpc than the cold-gas-poor systems. We show that while the hot atmospheres of the cold-gas-poor galaxies are thermally stable outside of their innermost cores, the atmospheres of the cold-gas-rich systems are prone to cooling instabilities. This provides considerable weight to the argument that cold gas in giant ellipticals is produced chiefly by cooling from the hot phase. We show that cooling instabilities may develop more easily in rotating systems and discuss an alternative condition for thermal instability for this case. The hot atmospheres of cold-gas-rich galaxies display disturbed morphologies indicating that the accretion of clumpy multiphase gas in these systems may result in variable power output of the AGN jets, potentially triggering sporadic, larger outbursts. In the two cold-gas-poor, X-ray morphologically relaxed galaxies of our sample, NGC 1399 and NGC 4472, powerful AGN outbursts may have destroyed or removed most of the cold gas from the cores, allowing the jets to propagate and deposit most of their energy further out, increasing the entropy of the hot galactic atmospheres and leaving their cores relatively undisturbed.
The analgesic efficacy and adverse effects of a single perioperative dose of dexamethasone are unclear. We performed a systematic review to evaluate the impact of a single i.v. dose of dexamethasone ...on postoperative pain and explore adverse events associated with this treatment.
MEDLINE, EMBASE, CINAHL, and the Cochrane Register were searched for randomized, controlled studies that compared dexamethasone vs placebo or an antiemetic in adult patients undergoing general anaesthesia and reported pain outcomes.
Forty-five studies involving 5796 patients receiving dexamethasone 1.25–20 mg were included. Patients receiving dexamethasone had lower pain scores at 2 h {mean difference (MD) −0.49 95% confidence interval (CI): −0.83, −0.15} and 24 h MD −0.48 (95% CI: −0.62, −0.35) after surgery. Dexamethasone-treated patients used less opioids at 2 h MD −0.87 mg morphine equivalents (95% CI: −1.40 to −0.33) and 24 h MD −2.33 mg morphine equivalents (95% CI: −4.39, −0.26), required less rescue analgesia for intolerable pain relative risk 0.80 (95% CI: 0.69, 0.93), had longer time to first dose of analgesic MD 12.06 min (95% CI: 0.80, 23.32), and shorter stays in the post-anaesthesia care unit MD −5.32 min (95% CI: −10.49 to −0.15). There was no dose–response with regard to the opioid-sparing effect. There was no increase in infection or delayed wound healing with dexamethasone, but blood glucose levels were higher at 24 h MD 0.39 mmol litre−1 (95% CI: 0.04, 0.74).
A single i.v. perioperative dose of dexamethasone had small but statistically significant analgesic benefits.
Aims
To determine the sensitivity of five strains of Staphylococcus aureus to five essential oils (EOs) and to investigate the anti‐biofilm activity of lemongrass and grapefruit EOs.
Methods and ...Results
Antimicrobial susceptibility screening was carried out using the disk diffusion method. All of the strains tested were susceptible to lemongrass, grapefruit, bergamot and lime EOs with zones of inhibition varying from 2·85 to 8·60 cm although they were resistant to lemon EO. Lemongrass EO inhibited biofilm formation at 0·125% (v/v) as measured by colorimetric assay and at 0·25% (v/v) no metabolic activity was observed as determined by 2,3‐bis(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium‐5‐carboxanilide (XTT) reduction. Grapefruit EO did not show any anti‐biofilm activity. Following exposure to lemongrass EO extensive disruption to Staph. aureus biofilms was shown under scanning electron microscopy.
Conclusions
In comparison to the other EOs tested, lemongrass exhibited the most effective antimicrobial and anti‐biofilm activity.
Significance and Impact of the Study
The effect of lemongrass EO highlights its potential against antibiotic resistant Staph. aureus in the healthcare environment.
We perform a statistical study of electromagnetic ion cyclotron (EMIC) waves detected by the Van Allen Probes mission to investigate the spatial distribution of their occurrence, wave power, ...ellipticity, and normal angle. The Van Allen Probes have been used which allow us to explore the inner magnetosphere (1.1 to 5.8 RE). Magnetic field measurements from the Electric and Magnetic Field Instrument Suite and Integrated Science on board the Van Allen Probes are used to identify EMIC wave events for the first 22 months of the mission operation (8 September 2012 to 30 June 2014). EMIC waves are examined in H+, He+, and O+ bands. Over 700 EMIC wave events have been identified over the three different wave bands (265 H+‐band events, 438 He+‐band events, and 68 O+‐band events). EMIC wave events are observed between L = 2–8, with over 140 EMIC wave events observed below L = 4. Results show that H+‐band EMIC waves have two peak magnetic local time (MLT) occurrence regions: prenoon (09:00 < MLT ≤ 12:00) and afternoon (15:00 < MLT ≤ 17:00) sectors. He+‐band EMIC waves feature an overall stronger dayside occurrence. O+‐band EMIC waves have one peak region located in the morning sector at lower L shells (L < 4). He+‐band EMIC waves average the highest wave power overall (>0.1 nT2/Hz), especially in the afternoon sector. Ellipticity observations reveal that linearly polarized EMIC waves dominate in lower L shells.
Key Points
A statistical study of EMIC waves observed by the Van Allen Probes is performed
The occurrence and wave properties of the EMIC waves are examined
Linearly polarized EMIC waves dominate lower L shells (L < 4)
We present an analysis of the 2-10 keV X-ray emission associated with the active galactic nuclei (AGN) in brightest cluster galaxies (BCGs). Our sample consists of 32 BCGs that lie in highly X-ray ...luminous cluster of galaxies (
3\times 10^{44}\,{\rm erg}\,{\rm s}^{-1}\,$>
) in which AGN-jetted outflows are creating and sustaining clear X-ray cavities. Our sample covers the redshift range 0 < z < 0.6 and reveals strong evolution in the nuclear X-ray luminosities, such that the black holes in these systems have become on average at least 10 times fainter over the last 5 Gyr. Mindful of potential selection effects, we propose two possible scenarios to explain our results: (1) either that the AGN in BCGs with X-ray cavities are steadily becoming fainter, or more likely, (2) that the fraction of these BCGs with radiatively efficient nuclei is decreasing with time from roughly 60 per cent at z 0.6 to 30 per cent at z 0.1. Based on this strong evolution, we predict that a significant fraction of BCGs in z 1 clusters may host quasars at their centres, potentially complicating the search for such clusters at high redshift. In analogy with black hole binaries and based on the observed Eddington ratios of our sources, we further propose that the evolving AGN population in BCGs with X-ray cavities may be transiting from a canonical low/hard state, analogous to that of X-ray binaries, to a quiescent state over the last 5 Gyr.
We report the results of a multiwavelength study of the nearby galaxy group, Abell 3581 (z = 0.0218). This system hosts the most luminous cool core of any nearby group and exhibits active radio mode ...feedback from the supermassive black hole in its brightest group galaxy, IC 4374. The brightest galaxy has suffered multiple active galactic nucleus outbursts, blowing bubbles into the surrounding hot gas, which have resulted in the uplift of cool ionized gas into the surrounding hot intragroup medium. High velocities, indicative of an outflow, are observed close to the nucleus and coincident with the radio jet. Thin dusty filaments accompany the uplifted, ionized gas. No extended star formation is observed; however, a young cluster is detected just north of the nucleus. The direction of rise of the bubbles has changed between outbursts. This directional change is likely due to sloshing motions of the intragroup medium. These sloshing motions also appear to be actively stripping the X-ray cool core, as indicated by a spiralling cold front of high-metallicity, low-temperature, low entropy gas.
High gradients of energy gain and high energy efficiency are necessary parameters for compact, cost-efficient and high-energy particle colliders. Plasma Wakefield Accelerators (PWFA) offer both, ...making them attractive candidates for next-generation colliders. In these devices, a charge-density plasma wave is excited by an ultra-relativistic bunch of charged particles (the drive bunch). The energy in the wave can be extracted by a second bunch (the trailing bunch), as this bunch propagates in the wake of the drive bunch. While a trailing electron bunch was accelerated in a plasma with more than a gigaelectronvolt of energy gain, accelerating a trailing positron bunch in a plasma is much more challenging as the plasma response can be asymmetric for positrons and electrons. We report the demonstration of the energy gain by a distinct trailing positron bunch in a plasma wakefield accelerator, spanning nonlinear to quasi-linear regimes, and unveil the beam loading process underlying the accelerator energy efficiency. A positron bunch is used to drive the plasma wake in the experiment, though the quasi-linear wake structure could as easily be formed by an electron bunch or a laser driver. The results thus mark the first acceleration of a distinct positron bunch in plasma-based particle accelerators.
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