Purpose
Metastatic colorectal cancer (mCRC) is a lethal disease and fluorouracil–leucovorin–irinotecan (FOLFIRI) plus bevacizumab (bev) is a standard approach. Hence, there is a strong need for ...identifying new prognostic factors to show the efficacy of FOLFIRI-bev.
Methods
This is a retrospective study including patients (
n
= 90) with mCRC from two centers in Turkey. Neutrophil/lymphocyte (N/L) ratio, platelet count, albumin, and C-reactive protein (CRP) were recorded before FOLFIRI-bev therapy. The efficacy of these factors on progression-free survival (PFS) was analyzed with Kaplan Meier and Cox regression analysis. And the cutoff value of N/L ratio was analyzed with ROC analysis.
Results
The median age was 56 years (range 21–80). Forty-seven percent of patients with N/L ratio >2.5 showed progressive disease versus 43 % in patients with N/L ratio <2.5 (
p
= 0.025). The median PFS was 8.1 months for the patients with N/L ratio >2.5 versus 13.5 months for the patients with N/L ratio <2.5 (
p
= 0.025). At univariate Cox regression analysis, high baseline neutrophil count, LDH, N/L ratio, and CRP were all significantly associated with poor prognosis. At multivariate Cox regression analysis, CRP was confirmed to be a better independent prognostic factor. CRP variable was divided into above the upper limit of normal (ULN) and normal value. The median PFSs of the patients with normal and above ULN were 11.3 versus 5.8 months, respectively (
p
= 0.022).
Conclusions
CRP and N/L ratio are potential predictors for advanced mCRC treated with FOLFIRI-bev.
Introduction
Our objective was to determine whether serum leptin levels and obesity-related factors could affect outcome for metastatic breast cancer (MBC) patients treated with aromatase inhibitors ...(AIs).
Methods
Sixty MBC patients treated with first line hormonal therapy were enrolled in this study.
Results
Median age was 51 years (range 28–75). Median leptin level was 19400 pg/ml (1970–91900) and estradiol level 29.6 pg/ml (4.0–181.9). Factors associated with overall survival in univariate analysis were age and waist-to-hip ratio (WHR), whereas only WHR retained significance in the multivariate analysis. However, no factor was associated with progression-free survival. However, WHR was found to be a significant prognostic marker only if the leptin level was ≥19400 pg/ml (HR = 0.38; 95% CI: 0.16–0.91).
Conclusions
This study suggests that serum leptin levels and WHR together may serve as potential prognostic markers in MBC patients treated with AIs.
Primary malignant melanomas of uterine cervix are quite rarely seen neoplasms, and long-life prognosis of patients with this disease is poor. Immunohistochemical methods and exclusion of other ...primary melanoma sites are used to confirm the diagnosis. As with other melanomas, cervix malignant melanomas may also cause cardiac metastases. Cardiac metastases are among rarely seen but more commonly encountered cases, compared to primary cardiac tumors. Here, we present a case of biatrial cardiac metastases in a 73-year-old patient with uterine cervix malignant melanomas. The patient underwent echocardiography, cardiac magnetic resonance imaging, and computed tomography. Our report shows the importance of advanced diagnostic techniques, such as cardiac magnetic resonance, not only for the detection of cardiac masses, but for a better anatomic definition and tissue characterization. Although the cases of malignant melanomas leading to multiple cardiac metastasis were reported in literature, the metastatic concurrence of malignant melanomas in both right and left atriums is quite rarely encountered as metastatic malignant melanomas. Also, another intriguing point in our case is that the primary lesion of our case was stemmed from uterine cervix, but not skin.
The aim of this study was to use echocardiographic techniques to determine the possible cardiotoxic effects of low molecular weight tyrosine-kinase inhibitors (TKI) in patients receiving the therapy ...for the first time.
Thirty patients (17 females; 13 males; mean age 49±16; range 22 to 76 years) who met the exclusion criteria and were diagnosed as having malignancy were enrolled. All patients underwent conventional echocardiography and tissue Doppler imaging (TDI) prior to the treatment. The conventional echocardiogram was repeated 2 months later as the patients were concurrently receiving therapy. Myocardial Performance Index was obtained by conventional echocardiography and by TDI techniques to evaluate left ventricular systolic and diastolic function.
Statistically significant increase occurred in mean left ventricle (LV) end-systolic volume. However, there was significant decrease in both mean LV ejection fraction and LV stroke volume values (64±3, 62±4, p=0.000 and 67±13, 61±13, p=0.000, respectively). Anterior wall Em/Am ratio measured by using the TDI technique was significantly decreased at the end of two months (0.99±0.49, 0.90±0.41, p=0.03). In addition, decreases were determined in Sm values obtained from all of four LV walls and also in mean Sm value, but this decrease was significant only for the lateral wall Sm measurement (12.8±2.9, 11.6±2.3, p=0.004).
Tyrosine-kinase inhibitors therapy can be administered safely to patients without predisposing factors for cardiotoxicity in short treatment intervals, and low molecular TKIs may cause subtle or clinically significant cardiotoxicity following the treatment period even in patients without predisposing factors for cardiotoxicity, so clinicians should consider this possibility.
AMAÇ Bu çalışma tıbbi onkoloji kliniğinde tedavi gören kanser hastalarının sosyodemografik özellikleri, sigara içme durumları ve sigara içmeye atfedilebilen kanser türlerinin sıklığını değerlendirmek ...amacı ile yapılmıştır. GEREÇ VE YÖNTEM Tanımlayıcı ve kesitsel tipteki bu çalışma onkoloji servisinde yatarak tedavi gören 459 kanser hastasında yapıldı. Veriler sosyodemografik özellikler, sigara ile ilgili tutum ve davranışları belirlemek amacı ile hazırlanan bir anket formu ile elde edildi. BULGULAR Katılanların yaş ortalaması 57.42±13.29 yaş (min: 18 ve maks: 91) olup, %52.9'u erkek idi. Halen sigara içme sıklığı %9.6, daha önce sigara içip bırakma %48.1, hiç sigara içmeme sıklığı %42.3 idi. Erkek hastalarda solunum sistemi (%32.1), GİS (%24.3) ve kolorektal (%18.9) kanserler sık görülürken, kadınlarda meme kanseri (%46.8), GİS (%15.3) ve kolorektal (%12.5) kanserler daha sık görülmekte idi. Sigara içen kanser hastalarında solunum sistemi kanseri görülme sıklığı %30.6 (n=81) iken, hiç sigara içmeyenlerde %4.6 (n=9) idi. Sigara içenlerde içmeyenlere göre solunum sistemi kanserlerinin görülme sıklığı RR=6.65 kez daha fazla idi. Solunum sistemi kanserlerinin %26.0'sı sigaraya atfedilmekte idi. SONUÇ Sigara özellikle akciğer kanserinin gelişiminde önemli rol oynamaktadır. Sık görülen kanserler cinsiyet ve yaşa göre farklılıklar gösterir. Bu nedenle kanser tarama programları geliştirilirken sosyodemografik özellikler göz önüne alınmalıdır.
Identification of biomarkers used for the prognostic evaluation of non-small cell lung cancer (NSCLC) patients is important. The aim of this study was to evaluate the potential prognostic value of ...XRCC1, ERCC1, ERCC2, and TP53 single nucleotide polymorphisms (SNPs) in completely resected NSCLC patients. In total, 130 patients, surgically treated for NSCLC between 2000 and 2012, were included. An analysis of SNPs from peripheral blood cells was performed by polymerase chain reaction. XRCC1 Arg399Gln, ERCC1 Asn118Asn, ERCC2 Lys751Gln, and TP53 Arg72Pro polymorphisms were evaluated in conjunction with clinical and pathological parameters and survival. Kaplan–Meier method and Cox regression analysis were used. Median age rate was 59.3, ranging between 36 and 78 years. Median relapse-free survival duration (RFS) was found as 46.2 months. In those with ERCC2 CC allele, median RFS was detected as 28.3 months (95 % confidence interval (CI), 20.8−35.8), 46.9 months in those with CT heterozygous (95 % CI, 18.6−75.2), and 80.1 months for those with TT mutant allel (95 % CI, 33.0−127.2). Median RFS was seen to be longer in mutant group and also statistically significant (
P
= 0.018). Additionally, upon evaluating CC normal group with CT + TT alleles including mutant alleles, median RFS was found as 56.5 months (95 % CI, 24.6−88.4) in CT + TT group, and this was statistically significant (
P
= 0.005) Also, median RFS was 15.1 months in those including ERCC2 CC allele and 56.5 months in CT + TT allele in the group with no adjuvant treatment (
P
= 0.001). In conclusion, our study showed that ERCC2/XPD polymorphism is an independent prognostic factor in operated NSCLC patients, and these findings should be supported with prospective studies.
Hepatitis B reactivation due to chemotherapy is a cause of serious morbidity and mortality in some of the patients with cancer. In this study, we retrospectively assessed the prevalence of hepatitis ...B reactivation among the patients undergoing cytotoxic chemotherapy. We investigated efficacy of lamivudine prophylaxis against hepatitis B reactivation as well.
Serum leptin level and waist-to-hip ratio Artac, Mehmet; Bozcuk, Hakan; Kiyici, Aysel ...
Breast cancer (Tokyo, Japan),
04/2013, Letnik:
20, Številka:
2
Journal Article
Recenzirano
Introduction Our objective was to determine whether serum leptin levels and obesity-related factors could affect outcome for metastatic breast cancer (MBC) patients treated with aromatase inhibitors ...(AIs). Methods Sixty MBC patients treated with first line hormonal therapy were enrolled in this study. Results Median age was 51 years (range 28-75). Median leptin level was 19400 pg/ml (1970-91900) and estradiol level 29.6 pg/ml (4.0-181.9). Factors associated with overall survival in univariate analysis were age and waist-to-hip ratio (WHR), whereas only WHR retained significance in the multivariate analysis. However, no factor was associated with progression-free survival. However, WHR was found to be a significant prognostic marker only if the leptin level was greater than or equal to19400 pg/ml (HR = 0.38; 95% CI: 0.16-0.91). Conclusions This study suggests that serum leptin levels and WHR together may serve as potential prognostic markers in MBC patients treated with AIs.
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from follicular dendritic cells in lymphoid follicles. FDCS has been increasingly reported in recent years. However, data ...on FDCS are mostly based on single case reports or case series and its natural history and standard treatment are not clear. To increase the understanding of this rare disease, we report our experience of three cases of FDCS with an analysis of the morphological and immunophenotypic characteristics, clinical course, treatment options and response to treatment. In addition, we reviewed the literature on FDCS.
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