In this paper we describe the OpenGeoSys (OGS) project, which is a scientific open-source initiative for numerical simulation of thermo-hydro-mechanical-chemical processes in porous media. The basic ...concept is to provide a flexible numerical framework (using primarily the Finite Element Method (FEM)) for solving multifield problems in porous and fractured media for applications in geoscience and hydrology. To this purpose OGS is based on an object-oriented FEM concept including a broad spectrum of interfaces for pre- and postprocessing. The OGS idea has been in development since the mid-eighties. We provide a short historical note about the continuous process of concept and software development having evolved through Fortran, C, and C++ implementations. The idea behind OGS is to provide an open platform to the community, outfitted with professional software-engineering tools such as platform-independent compiling and automated benchmarking. A comprehensive benchmarking book has been prepared for publication. Benchmarking has been proven to be a valuable tool for cooperation between different developer teams, for example, for code comparison and validation purposes (DEVOVALEX and CO
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BENCH projects). On one hand, object-orientation (OO) provides a suitable framework for distributed code development; however, the parallelization of OO codes still lacks efficiency. High-performance-computing efficiency of OO codes is subject to future research.
Abstract Objective Primary orthostatic tremor (OT) is a rare neurological disease of unknown pathophysiology characterized by a high-frequency tremor mainly of the legs when standing. The aim of this ...study was to examine its long-term course by subjective estimation and objective recording by serial posturography and to obtain further standardized epidemiological and clinical data on patients with OT. Methods A clinical cohort of 37patients with the diagnosis of primary OT was screened for this longitudinal follow-up study. Eighteen patients consented to participate. During study visit all patients underwent a standardized neurological examination and completed subjective scales and scores. Posturographic recordings at follow-up were compared to prior clinical posturographic measurements in 15cases. Results In our cohort the mean duration of symptoms was 14.1 ± 6.8 years. Subjectively, 78% of patients reported progression of the disease. Posturographic data (5.4 ± 4.0 years) revealed a significant increase of the total sway path (standing on firm ground with eyes open) from 2.4 ± 1.3 to 3.4 ± 1.4 m/min (p = 0.022) and of the total root mean square values from 9.8 ± 4.3 to 12.4 ± 4.8 mm (p = 0.028). None of these observations are explained by aging of the patients. Mean frequency of the tremor did not change over time (14.7 ± 1.9 Hz vs. 14.9 ± 2.0 Hz at follow-up). Clinically, most patients had signs of cerebellar dysfunction and a substantial portion also showed proprioceptive deficits in the long-term course. Conclusions This long-term follow-up study indicates, that primary OT is a progressive disorder. Furthermore, the clinical observation of cerebellar dysfunction in most OT patients in the long-term course might indicate an important role of the cerebellum in its pathophysiology.
Highlights • One third of patients with normal pressure hydrocephalus had impaired otolith function. • Patients with an increase of walking velocity after spinal tap test only had a significant ...increase of oVEMP amplitude. • Otolith dysfunction may contribute to imbalance in normal pressure hydrocephalus (NPH) and increased utricular function after spinal tap test may be relevant for gait improvement.
An impairment of eye movements, or nystagmus, is seen in many diseases of the central nervous system, in particular those affecting the brainstem and cerebellum, as well as in those of the vestibular ...system. The key to diagnosis is a systematic clinical examination of the different types of eye movements, including: eye position, range of eye movements, smooth pursuit, saccades, gaze-holding function and optokinetic nystagmus, as well as testing for the different types of nystagmus (e.g., central fixation nystagmus or peripheral vestibular nystagmus). Depending on the time course of the signs and symptoms, eye movements often indicate a specific underlying cause (e.g., stroke or neurodegenerative or metabolic disorders). A detailed knowledge of the anatomy and physiology of eye movements enables the physician to localize the disturbance to a specific area in the brainstem (midbrain, pons or medulla) or cerebellum (in particular the flocculus). For example, isolated dysfunction of vertical eye movements is due to a midbrain lesion affecting the rostral interstitial nucleus of the medial longitudinal fascicle, with impaired vertical saccades only, the interstitial nucleus of Cajal or the posterior commissure; common causes with an acute onset are an infarction or bleeding in the upper midbrain or in patients with chronic progressive supranuclear palsy (PSP) and Niemann–Pick type C (NP-C). Isolated dysfunction of horizontal saccades is due to a pontine lesion affecting the paramedian pontine reticular formation due, for instance, to brainstem bleeding, glioma or Gaucher disease type 3; an impairment of horizontal and vertical saccades is found in later stages of PSP, NP-C and Gaucher disease type 3. Gaze-evoked nystagmus (GEN) in all directions indicates a cerebellar dysfunction and can have multiple causes such as drugs, in particular antiepileptics, chronic alcohol abuse, neurodegenerative cerebellar disorders or cerebellar ataxias; purely vertical GEN is due to a midbrain lesion, while purely horizontal GEN is due to a pontomedullary lesion. The pathognomonic clinical sign of internuclear ophthalmoplegia is an impaired adduction while testing horizontal saccades on the side of the lesion in the ipsilateral medial longitudinal fascicule. The most common pathological types of central nystagmus are downbeat nystagmus (DBN) and upbeat nystagmus (UBN). DBN is generally due to cerebellar dysfunction affecting the flocculus bilaterally (e.g., due to a neurodegenerative disease). Treatment options exist for a few disorders: miglustat for NP-C and aminopyridines for DBN and UBN. It is therefore particularly important to identify treatable cases with these conditions.
In this work, we present a framework for numerical modeling of CO2 injection into porous media for enhanced gas recovery (EGR) from depleted reservoirs. Physically, we have to deal with ...non-isothermal, compressible gas flows resulting in a system of coupled non-linear PDEs. We describe the mathematical framework for the underlying balance equations as well as the equations of state for mixing gases. We use an object-oriented finite element method implemented in C++. The numerical model has been tested against an analytical solution for a simplified problem and then applied to CO2 injection into a real reservoir. Numerical modeling allows to investigate physical phenomena and to predict reservoir pressures as well as temperatures depending on injection scenarios and is therefore a useful tool for applied numerical analysis.
Two alternatives of primary variables are compared for two-phase flow in heterogeneous media by solving fully established benchmarks. The first combination utilizes pressure of the wetting fluid and ...saturation of the non-wetting fluid as primary variables, while the second employs capillary pressure of the wetting fluid and pressure of the non-wetting fluid. While the standard Galerkin finite element method (SGFEM) is known to fail in the physical reproduction of two-phase flow in heterogeneous media (unless employing a fully upwind correction), the second scheme with capillary pressure as a primary variable without applying an upwind technique produces correct physical fluid behaviour in heterogeneous media, as observed from experiments.
The IWAS project Ukraine deals among others with the water balance in the headwaters of the river Western Bug. During investigations in the sub-catchment Sasiv, a gap in the water balance was ...detected by Pluntke et al. (Environ Earth Sci, this issue, 2014). The runoff of this sub-catchment is significantly higher than that of any other catchment in the region. Unexpectedly, in 2011 the runoff was observed to be higher than precipitation. We hypothesize additional subsurface flow in the Sasiv catchment from adjacent aquifers. The hydrological model BROOK90 was used to model water flows. In addition to publicly available meteorological input data from the NOAA and ECA&C databases, own precipitation measurements in Sasiv were used. The mean seasonal leaf area index (LAI)—cycle of forest, grass, and agricultural land was determined using satellite data. To improve the output quality, the model was adapted for the superior catchment Kamianka-Buzka/Western Bug (2,500 km²). It was calibrated for the period 2001–2006 and validated for 2007–2011. Infiltration and drainage parameters were unknown, and were therefore calibrated applying Monte Carlo simulations. It was not possible to calibrate the sub-catchment Sasiv (107 km²) due to high deviations of the natural water balance. Thus, the model was calibrated for the superior catchment and afterwards applied to the Sasiv catchment. The monthly estimated inflow was calculated based on, first, a constant term, which is a fixed monthly inflow with its minimum in October (22 mm) and its maximum in May (41 mm). Secondly, a dynamic term was added. Here, different dependencies were tested, e.g., precipitation, soil moisture, groundwater level, and modelled runoff. The best coefficient of determination was achieved using a monthly modelled runoff from the 4 months before the current time. The model showed a good performance in the validation period (R² = 0.88). On average, the runoff observed in Sasiv consists of 60 percent groundwater inflow. At the gauge Kamianka-Buzka, this fraction is still about 5 %. The determined LAI cycles and the usage of an additional precipitation station near Sasiv significantly improved the quality of the water balance modelling in the Sasiv sub-catchment. The presented hydrological model approach was extended by hydrogeological simulations to enhance the understanding of processes in groundwater and surface water interactions. Therefore, it was a special challenge to model with scarce data the heterogeneous hydrogeological character of the catchment. The multi-level calibration enables a comprehensible estimation of annual groundwater recharge rates (30–700 mm) of the shallow quaternary aquifer, which is drained by the river Bug system.
The transport and storage of lithium-ion (Li-ion) batteries — damaged or in an undefined state — is a major safety concern for regulatory institutions, transportation companies, and manufacturers. ...Since (electro)chemical reactivity is exponentially temperature-dependent, cooling such batteries is an obvious measure for increasing their safety.
The present study explores the effect of cryogenic freezing on the electrochemical and physical stability of Li-ion cells. For this purpose, three different types of cells were repeatedly exposed to liquid nitrogen (LN2). Before and after each cooling cycle, electrical and electrochemical measurements were conducted to assess the impact of the individual freezing steps. While the electrochemical behavior of the cells did not change significantly upon exposure to LN2, it became apparent that a non-negligible number of cells suffered from physical changes (swelling) and functional failures. The latter defect was found to be caused by the current interrupt device of the cylindrical cells. This safety mechanism is triggered by the overpressure of expanding nitrogen which enters the cells at cryogenic temperatures.
This study underlines that the widely accepted reversibility of LN2-cooling on a material scale does not allow for a direct extrapolation toward the physical integrity of full cells. Since nitrogen enters the cell at cryogenic temperatures and expands upon rethermalization, it can cause an internal overpressure. This can, in turn, lead to mechanical damage to the cell. Consequently, a more appropriate temperature condition — less extreme than direct LN2 exposure — needs to be found.
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•Cryogenic cooling of lithium-ion cells with nitrogen can alter the cell performance.•Some samples showed very high impedance values, rendering the cells non-functional.•Nitrogen leaked into samples at cryogenic temperatures, expanding upon thawing.•Expanding nitrogen led to internal overpressure and eventually functional failures.
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