Aims. We investigate the distribution of the luminous and the dark matter components in the isolated ellipticals NGC 7052 and NGC 7785, which are embedded in an emitting hot gas halo, by means of ...relevant X-ray and photometric data. Methods. To calculate the dark matter distribution in these rare objects, we performed an improved X-ray analysis of the XMM-Newton data of NGC 7785, and we used former results based on Chandra data of NGC 7052. For each object we also derived the stellar spheroid length scale from the surface photometry and the spheroid stellar mass from an analysis of the galaxy spectral energy distribution. Results. We find that a dark matter component is present in these objects. It is subdominant and mixed with the luminous matter inside the optical region half-light radius wide, while it dominates the gravitational potential at outer radii. On the whole, the dark halo structure is very similar to that found around spirals of comparable luminosity and it is well reproduced by a Burkert halo, while a Sérsic spheroid accounts well for the baryonic component.
On being cancelled: a patient's perspective Kamath, M.; Babic, A.
British journal of anaesthesia,
February 2019, 2019-02-00, 20190201, Letnik:
122, Številka:
2
Journal Article
Context. X-ray surveys of Active Galactic Nuclei (AGN) indicate “cosmic downsizing”, with the comoving number density of high-luminosity objects peaking at higher redshifts (z~2) than low-luminosity ...AGN (z < 1). Aims. We test whether downsizing is caused by activity shifting towards low-mass black holes accreting at near-Eddington rates, or by a change in the average rate of accretion onto supermassive black holes. We estimate the black hole masses and Eddington ratios of an X-ray selected sample of AGN in the Chandra Deep Field South at z < 1, probing the epoch where AGN cosmic downsizing has been reported. Methods. Black hole masses are estimated both from host galaxy stellar masses, which are estimated from fitting to published optical and near-infrared photometry, and from near-infrared luminosities, applying established correlations between black hole mass and host galaxy properties. Both methods give consistent results. Comparison and calibration of possible redshift-dependent effects is also made using published faint host galaxy velocity dispersion measurements. Results. The Eddington ratios in our sample span the range ~10-5-1, with median $\log ( L_{\rm bol} / L_{\rm Edd})$ = -2.87, and with typical black hole masses $M_{{\rm BH}}$ ~ 108 $M_\odot$. The broad distribution of Eddington ratios is consistent with that expected for AGN samples at low and moderate luminosity. We find no evidence that the CDF-S AGN population is dominated by low-mass black holes accreting at near-Eddington ratios and the results suggest that diminishing accretion rates onto average-sized black holes are responsible for the reported AGN downsizing at redshifts below unity.
A neutrino with energy ∼290 TeV, IceCube-170922A, was detected in coincidence with the BL Lac object TXS 0506+056 during enhanced gamma-ray activity, with chance coincidence being rejected at ∼3 ...level. We monitored the object in the very-high-energy (VHE) band with the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) telescopes for ∼41 hr from 1.3 to 40.4 days after the neutrino detection. Day-timescale variability is clearly resolved. We interpret the quasi-simultaneous neutrino and broadband electromagnetic observations with a novel one-zone lepto-hadronic model, based on interactions of electrons and protons co-accelerated in the jet with external photons originating from a slow-moving plasma sheath surrounding the faster jet spine. We can reproduce the multiwavelength spectra of TXS 0506+056 with neutrino rate and energy compatible with IceCube-170922A, and with plausible values for the jet power of . The steep spectrum observed by MAGIC is concordant with internal γγ absorption above ∼100 GeV entailed by photohadronic production of a ∼290 TeV neutrino, corroborating a genuine connection between the multi-messenger signals. In contrast to previous predictions of predominantly hadronic emission from neutrino sources, the gamma-rays can be mostly ascribed to inverse Compton upscattering of external photons by accelerated electrons. The X-ray and VHE bands provide crucial constraints on the emission from both accelerated electrons and protons. We infer that the maximum energy of protons in the jet comoving frame can be in the range ∼1014 - 1018 eV.
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Magnetic resonance angiography (MRA) requires the use of contrast agents (CAs) to enable accurate diagnosis. There are currently no CAs on the market with appropriate pharmacokinetic ...(PK) parameters, namely long persistence in the blood, that can be easily used for MRA. We have recently synthesized amphiphilic building blocks loaded with gadolinium (Gd), which self-assemble into Gd-micelles in aqueous media, and have evaluated their potential as a blood-pool contrast agent (BPCA) in vivo. To assess the short and long term PK of Gd-micelles, the blood and organs of the mice were analyzed at t = 30 min, 1, 2, 3 h, 7, 14 and 21 days. Gd-DOTA was used as a control because it is the gold-standard CA for MRA despite its rapid clearance from the blood compartment. Gd-micelles circulated in the blood for more than 3 h postinjection whereas Gd-DOTA was eliminated less than half an hour postinjection. No side effects were observed in the mice up to the end of the study at 21 days and no accumulation of Gd was observed in the brain or bones. The Magnetic Resonance Imaging (MRI) parameters and the results of this in vivo study indicate the true BCPA properties of Gd-micelles and warrant further development.
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•Design and synthesis of a glucuronic acid prodrug of 5-aminolevulinic acid (GLU-ALA-Hex).•GLU-ALA-Hex displays excellent stability, reduced toxicity and β-glucuronidase-triggered ...activation.•PPIX fluorescence profile in vitro is comparable to clinically approved 5-ALA-Hex.•MCF7 breast cancer cell fluorescence photodetection.
Treatment of cancer cells by clinically approved hexyl ester of 5-aminolevulinic acid (ALA-Hex) induces accumulation of fluorescent porphyrins in tumors. This allows fluorescence photodiagnosis (PD) of bladder cancer by blue light illumination. However, PD of other cancers is hampered by acute toxicity of the compound limiting its use to local applications. We have designed and synthesized a new prodrug of ALA-Hex that tackles the stability-activity paradox of amino-modified 5-ALA prodrugs. The glucuronide prodrug Glu-ALA-Hex demonstrates excellent stability under physiological conditions and activation in the presence of the target enzyme. β-glucuronidase-triggered release of 5-ALA is programmed to yield fluorescence in tumor environment with elevated β-glucuronidase activity, a characteristic of many solid tumors. Glu-ALA-Hex produces similar levels of fluorescence as ALA-Hex in breast cancer MCF7 cells in vitro but with much lower non-specific cell toxicity.
Abstract
The coincident detection of GW170817 in gravitational waves and electromagnetic radiation spanning the radio to MeV gamma-ray bands provided the first direct evidence that short gamma-ray ...bursts (GRBs) can originate from binary neutron star (BNS) mergers. On the other hand, the properties of short GRBs in high-energy gamma-rays are still poorly constrained, with only ∼20 events detected in the GeV band, and none in the TeV band. GRB 160821B is one of the nearest short GRBs known at
z
= 0.162. Recent analyses of the multiwavelength observational data of its afterglow emission revealed an optical-infrared kilonova component, characteristic of heavy-element nucleosynthesis in a BNS merger. Aiming to better clarify the nature of short GRBs, this burst was automatically followed up with the MAGIC telescopes, starting from 24 s after the burst trigger. Evidence of a gamma-ray signal is found above ∼0.5 TeV at a significance of ∼ 3
σ
during observations that lasted until 4 hr after the burst. Assuming that the observed excess events correspond to gamma-ray emission from GRB 160821B, in conjunction with data at other wavelengths, we investigate its origin in the framework of GRB afterglow models. The simplest interpretation with one-zone models of synchrotron-self-Compton emission from the external forward shock has difficulty accounting for the putative TeV flux. Alternative scenarios are discussed where the TeV emission can be relatively enhanced. The role of future GeV–TeV observations of short GRBs in advancing our understanding of BNS mergers and related topics is briefly addressed.
One of the main challenges in ultrafast material science is to trigger phase transitions with short pulses of light. Here we show how strain waves, launched by electronic and structural precursor ...phenomena, determine a coherent macroscopic transformation pathway for the semiconducting-to-metal transition in bistable Ti
O
nanocrystals. Employing femtosecond powder X-ray diffraction, we measure the lattice deformation in the phase transition as a function of time. We monitor the early intra-cell distortion around the light absorbing metal dimer and the long range deformations governed by acoustic waves propagating from the laser-exposed Ti
O
surface. We developed a simplified elastic model demonstrating that picosecond switching in nanocrystals happens concomitantly with the propagating acoustic wavefront, several decades faster than thermal processes governed by heat diffusion.
Pancreatic cancer presents as advanced disease in >80% of patients; yet, appropriate ages to consider prevention and early detection strategies are poorly defined. We investigated age-specific ...associations and attributable risks of pancreatic cancer for established modifiable and non-modifiable risk factors.
We included 167 483 participants from two prospective US cohort studies with 1190 incident cases of pancreatic cancer during >30 years of follow-up; 5107 pancreatic cancer cases and 8845 control participants of European ancestry from a completed multicenter genome-wide association study (GWAS); and 248 893 pancreatic cancer cases documented in the US Surveillance, Epidemiology, and End Results (SEER) Program. Across different age categories, we investigated cigarette smoking, obesity, diabetes, height, and non-O blood group in the prospective cohorts; weighted polygenic risk score of 22 previously identified single nucleotide polymorphisms in the GWAS; and male sex and black race in the SEER Program.
In the prospective cohorts, all five risk factors were more strongly associated with pancreatic cancer risk among younger participants, with associations attenuated among those aged >70 years. The hazard ratios comparing participants with three to five risk factors with those with no risk factors were 9.24 95% confidence interval (CI) 4.11-20.77 among those aged ≤60 years, 3.00 (95% CI 1.85-4.86) among those aged 61-70 years, and 1.46 (95% CI 1.10-1.94) among those aged >70 years (Pheterogeneity = 3×10−5). These factors together were related to 65.6%, 49.7%, and 17.2% of incident pancreatic cancers in these age groups, respectively. In the GWAS and the SEER Program, the associations with the polygenic risk score, male sex, and black race were all stronger among younger individuals (Pheterogeneity ≤0.01).
Established risk factors are more strongly associated with earlier-onset pancreatic cancer, emphasizing the importance of age at initiation for cancer prevention and control programs targeting this highly lethal malignancy.
•We demonstrate an age-dependent pattern of relative risk for nearly all established risk factors for pancreatic cancer.•Associations between risk factors and pancreatic cancer were strongest among younger participants and weakened with age.•The age of target populations should be considered when designing prevention and control programs for pancreatic cancer.
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