Correntropy-Based Evolving Fuzzy Neural System Bao, Rong-Jing; Rong, Hai-Jun; Angelov, Plamen P. ...
IEEE transactions on fuzzy systems,
2018-June, 2018-6-00, Letnik:
26, Številka:
3
Journal Article
Recenzirano
Odprti dostop
In this paper, a correntropy-based evolving fuzzy neural system (CEFNS) is proposed for approximation of nonlinear systems. Different from the commonly used mean-square error criterion, correntropy ...has a strong outliers rejection ability through capturing the higher moments of the error distribution. Considering the merits of correntropy, this paper brings contributions to build evolving fuzzy neural system (EFNS) based on the correntropy concept to achieve a more stable evolution of the rule base and update of the rule parameters instead of the commonly used mean-square error criterion. The correntropy-EFNS (CEFNS) begins with an empty rule base, and all rules are evolved online based on the correntropy criterion. The consequent part parameters are tuned based on the maximum correntropy criterion, where the correntropy is used as the cost function so as to improve the non-Gaussian noise rejection ability. The steady-state convergence performance of the CEFNS is studied through the calculation of the steady-state excess mean square error (EMSE) in two cases: Gaussian noise; and non-Gaussian noise. Finally, the CEFNS is validated through a benchmark system identification problem, a Mackey-Glass time series prediction problem as well as five other real-world benchmark regression problems under both noise-free and noisy conditions. Compared with other EFNSs, the simulation results show that the proposed CEFNS produces better approximation accuracy using the least number of rules and training time and also owns superior non-Gaussian noise handling capability.
Sensory neurons are distinguished by distinct signaling networks and receptive characteristics. Thus, sensory neuron types can be defined by linking transcriptome-based neuron typing with the sensory ...phenotypes. Here we classify somatosensory neurons of the mouse dorsal root ganglion （DRG） by high-coverage single-cell RNA-sequencing （10 950 ±1 218 genes per neuron） and neuron size-based hierarchical clustering. Moreover, single DRG neurons responding to cutaneous stimuli are recorded using an in vivo whole-cell patch clamp technique and classified by neuron-type genetic markers. Small diameter DRG neurons are classified into one type of low-threshold mechanoreceptor and five types of mechanoheat nociceptors （MHNs）. Each of the MHN types is further categorized into two subtypes. Large DRG neurons are categorized into four types, including neurexophilin 1-expressing MHNs and mechanical nociceptors （MNs） expressing BAil-associated protein 2-like I （Baiap211）. Mechanoreceptors expressing trafficking protein particle complex 3-like and Baiap211-marked MNs are subdivided into two subtypes each. These results provide a new system for cataloging somatosensory neurons and their transcriptome databases.
Toad venom and toad skin have been widely used for treating various cancers in China. Bufadienolides are regarded as the main anticancer components of toad venom, but the difference on composition ...and anticancer activities of bufadienolides between toad venom and toad skin remains unclear.
Fractions enriched with free and conjugated bufadienolides were prepared from toad venom and toad skin. Bufadienolides in each fraction were comprehensively profiled by using a versatile UHPLC-TOF-MS method. Relative contents of major bufadienolides were determined by using three bufogenins and one bufotoxin as marker compounds with validated UHPLC-TOF-MS method. Furthermore, cytotoxicity of the fractions was examined by MTT assay.
Two fractions, i.e., bufogenin and bufotoxin fractions (TV-F and TV-C) were isolated from toad venom, and one bufotoxin fraction (TS-C) was isolated from toad skin. Totally 56 bufadienolides in these three fractions were identified, and 29 were quantified or semi-quantified. Bufotoxins were identified in both toad venom and toad skin, whereas bufogenins exist only in toad venom. Bufalin-3-conjugated bufotoxins are major components in toad venom, whereas cinobufotalin and cinobufagin-3-conjugated bufotoxins are main bufotoxins in toad skin. MTT assay revealed potent cytotoxicity of all the fractions in an order of TV-F>TV-C>TS-C.
Our study represents the most comprehensive investigation on the chemical profiles of toad venom and toad skin from both qualitative and quantitative aspects. Eight bufotoxins were identified in toad skin responsible for the cytotoxicity for the first time. Our research provides valuable chemical evidence for the appropriate processing method, quality control and rational exploration of toad skin and toad venom for the development of anticancer medicines.
Display omitted
In this paper, we propose a novel prognostic approach for remaining useful life estimation (RUL) with evolving joint prediction of continuous and discrete states which represent the signals and ...health states of systems respectively. The predictors are built with evolving capability of adapting structures and parameters online to capture the dynamic characteristics of systems during runtime. Moreover, the discrete states can be determined dynamically during the construction of the predictors for systems operating under different environments. In the testing phase, the optimum predictor for predicting continuous and discrete states jointly is chosen under the error and distance criteria. The RULs are estimated conveniently once the predicted signals fall into failure mode based on a distance metric. In order to validate the performance of the proposed approach, the widely used turbofan engine datasets are taken into consideration. Experimental results demonstrate the reasonability and superiority of the proposed approach compared to other approaches.
Ruthenium(II) polypyridyl complexes with long‐wavelength absorption and high singlet‐oxygen quantum yield exhibit attractive potential in photodynamic therapy. A new heteroleptic RuII polypyridyl ...complex, Ru(bpy)(dpb)(dppn)2+ (bpy=2,2′‐bipyridine, dpb=2,3‐bis(2‐pyridyl)benzoquinoxaline, dppn=4,5,9,16‐tetraaza‐dibenzoa,cnaphthacene), is reported, which exhibits a 1MLCT (MLCT: metal‐to‐ligand charge transfer) maximum as long as 548 nm and a singlet‐oxygen quantum yield as high as 0.43. Steady/transient absorption/emission spectra indicate that the lowest‐energy MLCT state localizes on the dpb ligand, whereas the high singlet‐oxygen quantum yield results from the relatively long 3MLCT(Ru→dpb) lifetime, which in turn is the result of the equilibrium between nearly isoenergetic excited states of 3MLCT(Ru→dpb) and 3ππ*(dppn). The dppn ligand also ensures a high binding affinity of the complex towards DNA. Thus, the combination of dpb and dppn gives the complex promising photodynamic activity, fully demonstrating the modularity and versatility of heteroleptic RuII complexes. In contrast, Ru(bpy)2(dpb)2+ shows a long‐wavelength 1MLCT maximum (551 nm) but a very low singlet‐oxygen quantum yield (0.22), and Ru(bpy)2(dppn)2+ shows a high singlet‐oxygen quantum yield (0.79) but a very short wavelength 1MLCT maximum (442 nm).
Effective cooperation of the ligands 2,3‐bis(2‐pyridyl)benzoquinoxaline (dpb) and 4,5,9,16‐tetraaza‐dibenzoa,cnaphthacene (dppn) gives the tris‐heteroleptic complex Ru(bpy)(dpb)(dppn)2+ (bpy=2,2′‐bipyridine), which has a metal‐to‐ligand charge‐transfer maximum at 548 nm, a singlet‐oxygen quantum yield of 0.43, strong binding affinity towards double‐stranded DNA, and thus promising photodynamic activity.
Ginseng (Panax ginseng C.A. Meyer) is widely used in Asian communities for treating cardiovascular diseases. However, the mechanism by which it protects the myocardium in ischemia–reperfusion (I/R) ...injury remains unclear. In this study, we aim to investigate whether a standardized ginseng extract (RSE) protects rodent hearts against I/R injury and if glucocorticoid and/or estrogen receptor-mediated activation of Akt and Erk1/2 (the reperfusion injury salvage kinase pathway, RISK) and subsequent nitric oxide (NO) synthesis signaling are involved in this effect.
Rats or gene-deleted mice were subjected to 30min ischemia by occluding the left anterior descending coronary artery and 90min reperfusion. Infarct size, serum level of creatine kinase (CK), lactate dehydrogenase (LDH), and NO, expression and phosphorylation of glucocorticoid receptor (GR), estrogen receptor (ER), phosphatidylinositol-3 kinase (PI3K), Akt, NO synthase (NOS), extracellular signal-regulated kinase (Erk) 1/2, p38, and c-Jun NH2 terminal kinases (JNK) were examined in rat or mice treated with or without RSE in the absence or presence of pharmacological inhibitors.
RSE significantly reduced infarct size in a dose-dependent manner and reduced the incidence of arrhythmia, increased serum NO production, reduced serum activities of creatine kinase and lactate dehydrogenase. The infarct size reduction effect of RSE was abolished by RU468 (an inhibitor of GR), tamoxifen (an inhibitor of ER), LY294002 (an inhibitor of PI3K), Akt inhibitor IV (an inhibitor of Akt protein kinase), U0126 (an inhibitor of Erk1/2) and NG-nitro-l-arginine methyl ester hydrochloride (an inhibitor of NOS), but not actinomycin D (an inhibitor of transcription process). RSE also significantly increased the activation of GR/ER, PI3K–Akt–eNOS cascades and Erk1/2 signaling in rat heart. However, RSE did not markedly reduce infarct size in endothelium NOS−/− mice. This differs from its effect in inducible NOS−/− and wild type mice, suggesting that endothelium NOS is required for the beneficial effect of RSE on the heart.
Our findings showed for the first time that RSE protects hearts subjected to acute I/R injury and the infarct size reduction effect of RSE is associated with GR and/or ER-mediated Akt and Erk1/2 activation in an endothelium NOS-dependent manner.
The subterranean insect Bradysia odoriphaga (Diptera: Sciaridae) is an important pest in China and is especially damaging to Chinese chive. This study determined the exposure temperatures and times ...required to kill various stages of B. odoriphaga in vitro, the optimal plastic film for soil solarization, and the effects of soil solarization on control of B. odoriphaga. In vitro mortality was 100% when adults, eggs, larvae, or pupae were exposed to a constant temperature of 40 °C for 1.3, 1.8, 2.8, or 3.7 h. Among four kinds of plastic film (white common plastic film, light blue anti-dropping film LBADF, white anti-dropping film, and black-white film), soil temperature increased fastest and remained over 40 °C for the longest time with 0.12-mm-thick LBADF located 30 cm above the soil surface. Favorable soil solarization with 0.12-mm-thick LBADF located at 30 cm above the soil surface or on the soil surface just 1 d after treatment provided 100% control of B. odoriphaga. The growth of Chinese chive was slower in solarized plots than in control plots for about 10 days but subsequently was faster in the solarized plots. At 20 days after treatment, the differences in yields between solarized plots and control plots were not statistically significant. This is the first report that soil solarization can be used to control B. odoriphaga in Chinese chive fields. This approach needs to be investigated for management of other plant diseases and insect pests.
•Bradysia odoriphaga adults and eggs were not differ, but were more sensitive to temperature than other stages.•Soil temperature increased with anti-dropping films was the highest, compared with the other kinds of films tested.•It is the first to report that favorable soil solarization just 1 d.•The yields of Chinese chives after 20 days might be significantly improved in the solarized plots.
► The Ag/C/Au nanocomposites were successfully synthesized. ► The Ag/C/Au nanocomposites were firstly applied in HRP immobilization and biosensor construction. ► The constructed biosensor exhibited ...excellent electrocatalytic activity for the detection of H2O2.
A novel enzymatic hydrogen peroxide sensor was successfully fabricated based on the nanocomposites containing of Ag/C nanocables and gold nanoparticles (AuNPs). Ag/C nanocables have been synthesized by a hydrothermal method and then AuNPs were assembled on the surface of Ag/C nanocables. The nanocomposites were confirmed by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy-dispersive X-ray spectrometry (EDS). The above nanocomposites have satisfactory chemical stability and excellent biocompatibility. Cyclic voltammetry (CV) was used to evaluate the electrochemical performance of the Ag/C/Au nanocomposites at glassy carbon electrode (GCE). The results indicated that the Ag/C/Au nanocomposites exhibited excellent electrocatalytic activity to the reduction of H2O2. It offered a linear range of 6.7×10−9 to 8.0×10−6M, with a detection limit of 2.2×10−9M. The apparent Michaelis–Menten constant of the biosensor was 51.7×10−6M. These results indicated that Ag/C/Au nanocomposites have potential for constructing of a variety of electrochemical biosensors.
Pro-inflammatory factors may be associated with abnormalities in functional brain networks, which may be a mechanism in the pathogenesis of major depressive disorder (MDD). Electroencephalogram (EEG) ...microstates reflect the functioning of brain networks. However, the relationship between pro-inflammatory factors and the microstate abnormalities in patients with MDD is poorly understood. 24 MDD patients and 24 age-and sex-matched healthy controls (HC) were recruited. Montgomery-Asberg Depression Rating Scale(MADRS) were assessed. Serum (interleukin- 2(IL- 2), tumor necrosis factor-α (TNF-α) and hs-C-reactive protein (CRP)and EEG data were collected. K-means clustering was performed to characterize different microstates. For each microstate, duration, occurrence and coverage were estimated. Four microstates (e.g. A, B, C, D) were characterized, MDD group showed lower duration, occurrence and coverage of microstate B and microstate D, while higher duration of microstate A and microstate C and levels of IL-2, TNF-α, hs-CRP than HC group. The duration, occurrence and coverage of microstate D were negatively correlated with levels of pro-inflammatory factors (IL-2, TNF- α and hs- CRP) (all P < 0.05). Serum pro-inflammatory induced the abnormalities of microstate D. Together, these findings add to the understanding of the pathophysiology of MDD and point to pro-inflammatory factors contribute to EEG microstate abnormalities in patients with MDD.
PDF
