Trimetazidine is a new metabolic antiischemic agent, which increases the tolerance of cardiomyocytes to ischemia. The aim of the study was to evaluate the effect of additional trimatazidine therapy ...in patients with ischemic cardiomyopathy (ICMP) in comparison with standard therapy of cardiac insufficiency. According to the results of the study, trimetazidine improves the clinical status, functional class of cardiac insufficiency, left ventricular ejection fraction, in ICMP patients. Trimetazidine increases physical exercise tolerance according to the results of six-minute walking test. Thus, the optimization of myocardial energetic metabolism may be a promising perspective in the treatment of coronary heart disease with systolic dysfunction.
During warm periods of the year under unregulated work regimen the thermal state of the workers of glass manufacturing hot shops was regarded as discomfort. Under regulated work regimen the indices ...of workers' thermal state and hemodynamics were stabilized at a lower level. The dynamics of changes of the central nervous neuromuscular systems was also more favourable compared to the unregulated regimen. It was considered advisable to restrict the time of continuous stay at the workplace with heating microclimate for those engaged into work of mean intensity by 48 min. It was suggested to supply the workplace with the air with adequate microclimatic parameters and to organize health and psychophysiologic relief rooms.
Two methods of identifying satellite associations were compared in ten normal donors. Conventional Giemsa stain proved to identify by 31% less of 3-chromosomal associations, by 50% less of 4- and 5-, ...and by 66.6% less of 6-chromosomal associations than in staining with ammoniacal silver, whereas the number of 2-chromosomal associations was by 10% greater, this conditioning the prevalence of small associations. Silver staining used to expose intersatellite associations revealed acrocentric chromosomes mutually oriented, placed close to one another, but without any intersatellite connection. In Giemsa-stained preparations these are considered to be associating, which increases the number of multiple groups. Both errors of the conventional Giemsa method cannot be corrected. Identification of associations according to intersatellite connections is free of these errors after silver staining.
Intersatellite connections between acrocentric chromosomes in associations were revealed by the method of thermal ammoniacal silver staining. The associations were allotted to the corresponding ...groups on the basis of the number of chromosomes. Distribution of D- and G-chromosomes in associations was studied on the basis of 714 associations from 500 metaphase plates of 10 normal individuals. The hypotheses of hypergeometric, binomial, Poisson, uniform and exponential distribution laws of D- and G-chromosomes in associations were rejected. The hypothesis of normal distribution was not rejected. The principal characteristics of normal distribution law were found. The distribution law of the number of D- and G-chromosomes in associations was written analytically; the central moments and other characteristics were presented.
