Starting from a Black feminist standpoint, this reflexive article uniquely draws on empirical data and recollections from two research studies to consider experiences of researching Pakistani ...communities from the assumed position of an insider. In doing so the article provides a first-hand account of insider-outsider experiences in the field from the perspective of a qualitative researcher (who is a woman of minority ethnic background). Examples from the data reveal how factors such as a deep understanding of social and religious practices constitute types of insider knowledge necessary for gathering culturally relevant and fine-grained information. The methodological and ethical advantages and dilemmas of conducting research positioned as an insider include, knowledge of place and cultural identification as aiding access to and research with communities seldom heard in research, but also how commonalities–gender, race– can fuel participant reluctance and hostility. The articles main contribution, however, is to expose the shifting nature of the insider-outsider position whereby in some instances the assumed insider can become an outsider. This has methodological and ethical implications such as profound emotional impacts on the researcher and potentially destabilising effects on research.
The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China ...and spread around the world. Genomic analysis revealed that SARS-CoV-2 is phylogenetically related to severe acute respiratory syndrome-like (SARS-like) bat viruses, therefore bats could be the possible primary reservoir. The intermediate source of origin and transfer to humans is not known, however, the rapid human to human transfer has been confirmed widely. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. However, few broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulted in clinical recovery. In the current review, we summarize and comparatively analyze the emergence and pathogenicity of COVID-19 infection and previous human coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). We also discuss the approaches for developing effective vaccines and therapeutic combinations to cope with this viral outbreak.
Using data from a large primarily qualitative research project on how people from Black, Asian and Minority Ethnic (BAME) communities experience and access health services, this methodological ...article focuses on the role of the community gatekeeper – a role that has significance for research teams globally when attempting to involve those facing multiple forms of exclusion. Drawing on standpoint feminist principles and using a reflexive approach, researcher positionality, situated knowledges, and the power dynamics between researchers, participants, and community gatekeepers are reflected upon. Addressing a gap in the literature by providing real-life examples of the power and influence of gatekeepers at all stages of the research process, the findings reveal: the extent to which gatekeepers of research with BAME participants are facilitative or obstructive during the research process; how they affect processes such as the recruitment of participants, access to community venues, the conduct of the research interview, and the dissemination of findings; and finally, the implications for future research with so called “hard-to-reach” groups.
The new decade of the 21
century (2020) started with the emergence of a novel coronavirus known as SARS-CoV-2 that caused an epidemic of coronavirus disease (COVID-19) in Wuhan, China. It is the ...third highly pathogenic and transmissible coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in humans. The source of origin, transmission to humans, and mechanisms associated with the pathogenicity of SARS-CoV-2 are not yet clear, however, its resemblance to SARS-CoV and several other bat coronaviruses was recently confirmed through genome sequencing-related studies. The development of therapeutic strategies is necessary in order to prevent further epidemics and cure infections. In this review, we summarize current information about the emergence, origin, diversity, and epidemiology of three pathogenic coronaviruses with a specific focus on the current outbreak in Wuhan, China. Furthermore, we discuss the clinical features and potential therapeutic options that may be effective against SARS-CoV-2.
Citrus peel as a source of functional ingredient: A review Rafiq, Shafiya; Kaul, Rajkumari; Sofi, S.A. ...
Journal of the Saudi Society of Agricultural Sciences,
October 2018, 2018-10-00, 2018-10-01, Letnik:
17, Številka:
4
Journal Article
Recenzirano
Odprti dostop
Citrus plants belonging to the family Rutaceae which include fruits such as orange, mandarin, lime, lemon, sour orange and grapefruitappear as a well known promising source of multiple beneficial ...nutrients for human beings. Processing of citrus by-products potentially represents a rich source of phenolic compounds and dietary fibre, owing to the large amount of peel produced. These citrus fruit residues, which are generally discarded as waste in the environment, can act as potential nutraceutical resources. Due to their low cost and easy availability such wastes are capable of offering significant low-cost nutritional dietary supplements. The utilization of these bioactive rich citrus residues can provide an efficient, inexpensive, and environment friendly platform for the production of novel nutraceuticals or for the improvement of older ones. This review systematically summarized the potential components present in citrus peel, which generally discarded as waste.
As a neurotropic virus, human Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease (HFMD) and may develop severe neurological disorders in infants. Toll-like receptor 7 (TLR7) acts as ...an innate immune receptor and is also a death receptor in the central nervous system (CNS). However, the mechanisms underlying the regulation of TLR7-mediated brain pathogenesis upon EV71 infection remain largely elusive. Here we reveal a novel mechanism by which EV71 infects astrocytes in the brain and induces neural pathogenesis via TLR7 and interleukin-6 (IL-6) in C57BL/6 mice and in human astroglioma U251 cells. Upon EV71 infection, wild-type (WT) mice displayed more significant body weight loss, higher clinical scores, and lower survival rates as compared with TLR7-/- mice. In the cerebral cortex of EV71-infected mice, neurofilament integrity was disrupted, and inflammatory cell infiltration and neurodegeneration were induced in WT mice, whereas these were largely absent in TLR7-/- mice. Similarly, IL-6 production, Caspase-3 cleavage, and cell apoptosis were significantly higher in EV71-infected WT mice as compared with TLR7-/- mice. Moreover, EV71 preferentially infected and induced IL-6 in astrocytes of mice brain. In U251 cells, EV71-induced IL-6 production and cell apoptosis were suppressed by shRNA-mediated knockdown of TLR7 (shTLR7). Moreover, in the cerebral cortex of EV71-infected mice, the blockade of IL-6 with anti-IL-6 antibody (IL-6-Ab) restored the body weight loss, attenuated clinical scores, improved survival rates, reduced the disruption of neurofilament integrity, decreased cell apoptotic induction, and lowered levels of Caspase-3 cleavage. Similarly, in EV71-infected U251 cells, IL-6-Ab blocked EV71-induced IL-6 production and cell apoptosis in response to viral infection. Collectively, it's exhibited TLR7 upregulation, IL-6 induction and astrocytic cell apoptosis in EV71-infected human brain. Taken together, we propose that EV71 infects astrocytes of the cerebral cortex in mice and human and triggers TLR7 signaling and IL-6 release, subsequently inducing neural pathogenesis in the brain.
ABSTRACT This research is aimed to investigate wider phenomenon of possible need for legislation for regulation of social media in Pakistan. In-depth interview research method was applied under ...Qualitative study to investigate this phenomenon. Overall, 10 respondents from law and media departments from public as well as private sector universities of five main cities were chosen to collect their opinion with the help of 15 structured questionnaire with open ended approach. The study found out that there was no legislation existent for regulation of social media in Pakistan. The study revealed voices were raised from different corners of society including journalistic bodies labelling restriction and embargo on freedom of speech. The study concluded that the government should introduce such legislation after having detailed discussion with relevant stakeholders including public sector media organizations, information departments, law and media departments and other relevant stakeholders. The study concluded that socially responsible legislation was required for socially responsible social media in Pakistan. Purpose: The basic objective of this study was to unearth existing legal framework for regulation of social media in the country at par with the international best standards for regulation of social media. This study was tasked to ascertain the opinion of the relevant stakeholders of social media of public and private sector and recommend socially responsible social media in the country. However, the legislation should equally be acceptable for all the relevant stakeholders to make social media effective with its positive use in the long run. Design/Methodology/Approach: Qualitative study was employed along with in-depth interviews having 15 structured questions with open approach to collect data from 10 respondents from five media and law departments from public and private sector universities. Findings: The results showcased the findings that there was no existent legal framework for regulation of social media in hand. However, in recent past, the federal government has constituted a separate department called National Cyber Crime Investigation Agency (NCCIA) to regulate social media as well as investigate online crimes being committed on social media. However, the legislation was unavailable in this regard. The results revealed all the stakeholders can assemble at one point and draw an effective legislation in this regard to make social media socially reasonable. Implications/Originality/Value: This study seems valuable to the extent as it provides a ray of hope to the depressed consumers of social media especially the parents and teachers as the socially responsible legislation may turn social media as positive platforms. This study may also provide guidelines for the future researchers to investigate the phenome at provincial and district level in the country.
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•Our review explores recent advances in inorganic multifunctional nanomaterials for energy applications, shedding light on the latest developments in the field.•We highlight the ...diverse range of applications of inorganic nanomaterials in energy storage, conservation, transmission, and conversion, showcasing their versatility and potential impact on various sectors.•The manuscript discusses the exceptional thermal, mechanical, optical, and electrical properties of inorganic nanomaterials, emphasizing their significance in advancing next-generation energy technologies.•We provide insights into future research directions and challenges in scaling relationships within energy devices and inorganic nanomaterials, paving the way for continued innovation in the field.•Our review underscores the potential of inorganic nanomaterials to revolutionize energy applications and address pressing societal challenges related to energy utilization, highlighting their importance in shaping the future of sustainable energy systems.
Nowadays, one of the most promising and significant challenges for our society is achieving highly efficient energy utilization. To address the upcoming demands in energy applications, which demonstrate considerable potential for future trends, continuous efforts are necessary to develop improved and higher-performing inorganic multifunctional nanomaterials. Multifunctional inorganic nanomaterials have been extensively researched to meet the requirements of various energy applications or to enhance them further. Specific attention is given to inorganic nanomaterials for advanced energy storage, conservation, transmission, and conversion applications, which strongly rely on the optical, mechanical, thermal, catalytic, and electrical properties of energy materials. At the nanometer-scale range, triboelectric, piezoelectric, thermoelectric, electrochromic, and photovoltaic materials have made significant contributions to numerous energy sector applications. Functional inorganic materials possess unique properties, including excellent thermal and electrical conductivity, chemical stability, and a large surface area, which enhance their competitiveness in energy-related applications. Herein, recent research, development, and advances in inorganic multifunctional nanomaterials to enhance their performance are discussed, highlighting how devices combine the functionalities of nanomaterials. In this manner, we aim to provide insights into future applications and elucidate the ongoing research challenges currently facing this field.
Green nanotechnology has gained attraction in recent years due to the growing awareness of the environmental and health risks associated with traditional methods of nanomaterial synthesis. In the ...present study, nanocomposite (NCs) of silver and Iron were prepared using Zanthoxylum Armatum seeds aqueous extract which acts as a reducing, stabilizing, and capping agent. The synthesized NCs were characterized using UV/Vis Spectroscopy, powder X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), and EDX. The UV/Vis spectroscopy analysis of the NCs revealed the presence of a surface plasmonic resonance band occurring at 420 nm. Examination of the NCs through SEM demonstrated that they exhibited a nearly spherical morphology, with an average particle diameter measuring 54.8 nm. The crystalline nature of these NCs was verified through X-ray diffraction (XRD), and the calculation of crystallite size using the Scherrer-Debye equation yielded a value of 12.6 nm. The adsorption ability of newly synthesized nanocomposites was investigated against Acid Black 234 Dye. The results showed that a 0.5 g of NCs dose at pH 4 removed 99.3% of 10 mg/L of Acid Black 234 Dye within 60 min. Based on the findings of this research, it can be inferred that the that Ag-Fe NCs synthesized from Zanthoxylum Armatum seeds aqueous extract hold significant potential for addressing environmental pollution caused by Acid Black 234 Dye. The NCs were used as adsorbent for the removal of Acid Black 234 dye from the wastewater sample and showed 98% removal of dye from the commercial sample within 60 min. In this context, the research highlights that the environmentally friendly synthesis of Ag-Fe nanocrystals (Ag-Fe NCs) using Zanthoxylum Armatum as a mediator offers an efficient and cost-effective solution for mitigating environmental pollution.
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