In France metropolitan, 5 182 000 people have hearing loss (8.7% of the population), of which 4.1% are under 20 years of age. In children, hearing impairment is sought in the presence of depression, ...hyperactivity, impulsivity, instability accompanied by intense anger, and aggressive behavior. So far, the impact of dance and music on deaf people has been little studied. In this context, we recently initiated a project in mediated therapeutic workshops; Devoted to hearing-impaired adolescents or young adults with behavioral problems. The main objective of this project is to foster the adaptability of these young people with severe behavior problems. Protocol: 4 volunteers with moderate to profound deafness were included in this prospective study (2 F and 2 M, aged 19.5 ± 5.0 years). These patients exhibited daily behavioral disorders with stereotypies and aggressiveness with moderate to severe intensity according to the Behavior Problems Inventory (BPI-01). These young people attended weekly sessions lasting more than 12 months at the Music / Percussion Workshop in the presence of an instructor and nurse therapist. Outcome and Discussion: No voluntary withdrawal of the project was recorded. A very strong behavioral improvement was noted in 3/4 of the cases and a slight improvement in 1/4 of the cases. This study has shown that hearing loss is compensated by various adaptive processes, in particular by multi sensorial interactivity (such as the interactivity between touch and vision) and through mirror neuronal system. Conclusion: This study showed hearing impaired people are sensitive and receptive to the sound world and to rhythmic movement. This finding has been put to the benefit of rehabilitation through Music and Dance Therapies which has improved the behavioral disorder and blossoming of the group rehabilitation through Music and Dance Therapies of young people suffering from medium to profound deafness with severe behavior problems.
S-EOE-MAG
3-
β-alanine-CCK
4 vector (S-EOE-MAG
3-
β-alanine: S-(1-ethoxyethyl) mercaptoacetyltriglycyl -
β-alanine and CCK
4: Trp-Met-Asp-Phe-NH
2) was obtained by successive condensations of ...activated amino acids on resin with high chemical purity. This biovector was complexed at high dilution scale with
99mTc as well as at ponderable level with
185/187Re and
99Tc. In particular, this biovector was efficiently labelled with
99mTc (yield>95%) in one step under pH 7–8 and 45
°C conditions and then injected, In vivo, for biodistribution and targeting of pancreatic adenocarcinoma tumoral grafts (AR4-J).
99mTc-MAG
3-
β-alanine-CCK
4 exhibits remarkable biological properties related to its low background noise resulting from the fast blood clearance (tissular distribution half-life ≈10
min, elimination half-life ≈ 20
min), low hepatic uptake (0.03% injected dose/g of tissue 2
h after injection) and good affinity for the CCKB receptors (IC
50=8×10
−8
M) expressed by tumoral cells.
Nous évaluons dans cet article l'intérêt de la troponine Ic lors de la levée du corps dans le but d'orienter les circonstances de décès suspect. Dans ce contexte, 32 analyses de la troponine Ic ont ...été effectuées dans le cadre de la levée du corps dans la banlieue nord Parisienne (France) entre 2005 et 2006. Après l'examen clinique initial, la population globale a été subdivisée en 4 groupes: un premier groupe (GI) sans présence de lividité et rigidité, un deuxième groupe (GII) avec présence de lividité et rigidité, un troisième groupe (GIII) avec présence de signes de putréfaction et un quatrième groupe (GIV) dont les corps ont été conservés au funérarium à basse température. Il n'y a pas de différence significative entre le taux de troponine Ic concernant les groupes (GI) sans présence de lividité et rigidité et (GII) avec présence de lividité et de rigidité. Par contre il y a une augmentation significative du taux de troponine en présence de la putréfaction comparée à l'absence de décomposition (GIII>50μg/L versus GI+GII= 13,5μg/L avec p<0,001). En l'absence de putréfaction, la conservation des corps au funérarium ne semble pas modifier la cinétique de relargage de la troponine Ic. Par contre, il y a une augmentation significative de ce biomarqueur en relation avec la durée et l'intensité du massage cardiaque. Afin de s'affranchir du phénomène de putréfaction qui contribue à l'augmentation du taux de la troponine Ic, nous avons estimé statistiquement le seuil d'exclusion de ce marqueur à 11μg/L au-delà duquel toute valeur a été exclue et donc ininterprétable. Dans ces conditions la capacité prédictive de la troponine Ic vis à vis d'un décès d'origine cardiaque est optimale pour 0,8μg/L avec une sensibilité et une spécificité estimée respectivement à 86% et 100%. Cependant la pertinence d'application de ce biomarqueur requière la connaissance des circonstances et des éléments anamnestiques ainsi que l'observation et l'examen du corps. Moyennant ces précautions, la troponine Ic est à considérer comme une aide précieuse dans l'orientation du diagnostic de mort suspecte et en particulier la mort subite.
The aim of this biomedical trial was to clarify the physiological role of procalcitonin (PCT) in renal parenchyma apoptosis and fibrosis caused by acute childhood pyelonephritis. This prospective ...study enrolled 183 children. All children were treated with bi-therapy according to the French consensus on acute pyelonephritis treatment dated November 16, 1990: intra-vascular administration of ceftriaxone 50 mg/kg/day and netromicine 7 mg/kg/day during the first 48 hours, followed by specific antibiotherapy suited to antibiogram. On admission, PCT, C-reactive protein, and phospholipase A2 were quantified in serum. Scintigraphy monitoring with (99m)Tc-DMSA was performed on day 4 and 9 months later, in the presence of persistent abnormalities. On day 4, 78% presented renal parenchyma alterations and 30% renal fibrosis 9 months after admission. Paradoxically, PCT level was significantly lower in the presence of renal fibrosis due to cell apoptosis (4.19 vs 7.59 μgL(-1)). A significant increase in PCT indicated favorable progress (recovery 7.55 vs aggravation 3.34) and no difference between recovery and improvement. This result suggests the protective effect of PCT against apoptosis by nitric oxide down-regulation.
PDF
