The neurobiology of acute pain Bell, A.
The veterinary journal (1997),
July 2018, 2018-07-00, 20180701, Letnik:
237
Journal Article
Recenzirano
Odprti dostop
•Pain is transduced at the periphery by a variety of molecularly defined mechanisms dependent on the nature of the stimulus.•The spinal cord is a site of tremendous modulation of painful stimuli due ...to circuits that remain largely poorly understood.•Pain is perceived at the level of the brain due to coordinated activity in a variety of structures.•The pain pathway is inherently plastic which may result in hyperalgesia and allodynia.
The mechanisms by which noxious stimuli produce the sensation of pain in animals are complex. Noxious stimuli are transduced at the periphery and transmitted to the CNS, where this information is subject to considerable modulation. Finally, the information is projected to the brain where it is perceived as pain. Additionally, plasticity can develop in the pain pathway and hyperalgesia and allodynia may develop through sensitisation both peripherally and centrally. A large number of different ion channels, receptors, and cell types are involved in pain perception, and it is hoped that through a better understanding of these, new and refined treatments for pain will result.
•Nearly two in five adults were hesitant about getting a COVID-19 vaccine.•Male, older, white, married, and higher SES individuals more likely to vaccinate.•Republicans and Fox News viewers were less ...likely to vaccinate.•Being currently immunized against influenza predicted COVID-19 vaccination intent.•A better understanding of COVID-19 vaccination hesitancy is needed.
Public polling indicates that vaccine uptake will be suboptimal when COVID-19 vaccines become available. Formative research seeking an understanding of weak vaccination intentions is urgently needed.
Nationwide online survey of 804 U.S. English-speaking adults. Compensated participants were recruited from the U.S. through an internet survey panel of 2.5 million residents developed by a commercial survey firm. Recruitment was based on quota sampling to produce a U.S. Census-matched sample representative of the nation with regard to region of residence, sex, and age.
COVID-19 vaccination intentions were weak, with 14.8% of respondents being unlikely to get vaccinated and another 23.0% unsure. Intent to vaccinate was highest for men, older people, individuals who identified as white and non-Hispanic, the affluent and college-educated, Democrats, those who were married or partnered, people with pre-existing medical conditions, and those vaccinated against influenza during the 2019–2020 flu season.
In a multiple linear regression, significant predictors of vaccination intent were general vaccine knowledge (β = 0.311, p < .001), rejection of vaccine conspiracies (β = −0.117, p = .003), perceived severity of COVID-19 (β = 0.273, p < .001), influenza vaccine uptake (β = 0.178, p < .001), having ≥ 5 pre-existing conditions (β = 0.098, p = .003), being male (β = 0.119, p < .001), household income of ≥ $120,000 (β = 0.110, p = .004), identifying as a Democrat (β = 0.075, p < .029), and not relying upon social media for virus information (β = -0.090, p 〈002). Intent to vaccinate was lower for Fox News (57.3%) than CNN/MSNBC viewers (76.4%) (χ2(1) = 12.68, p < .001). Political party differences in threat appraisals and vaccine conspiracy beliefs are described.
Demographic characteristics, vaccine knowledge, perceived vulnerability to COVID-19, risk factors for COVID-19, and politics likely contribute to vaccination hesitancy.
Cities shape the lives and outlooks of billions of people, yet they have been overshadowed in contemporary political thought by nation-states, identity groups, and concepts like justice and freedom. ...The Spirit of Cities revives the classical idea that a city expresses its own distinctive ethos or values. In the ancient world, Athens was synonymous with democracy and Sparta represented military discipline. In this original and engaging book, Daniel Bell and Avner de-Shalit explore how this classical idea can be applied to today's cities, and they explain why philosophy and the social sciences need to rediscover the spirit of cities.
Bell and de-Shalit look at nine modern cities and the prevailing ethos that distinguishes each one. The cities are Jerusalem (religion), Montreal (language), Singapore (nation building), Hong Kong (materialism), Beijing (political power), Oxford (learning), Berlin (tolerance and intolerance), Paris (romance), and New York (ambition). Bell and de-Shalit draw upon the richly varied histories of each city, as well as novels, poems, biographies, tourist guides, architectural landmarks, and the authors' own personal reflections and insights. They show how the ethos of each city is expressed in political, cultural, and economic life, and also how pride in a city's ethos can oppose the homogenizing tendencies of globalization and curb the excesses of nationalism.
The Spirit of Cities is unreservedly impressionistic. Combining strolling and storytelling with cutting-edge theory, the book encourages debate and opens up new avenues of inquiry in philosophy and the social sciences. It is a must-read for lovers of cities everywhere.
ABSTRACT
The diffusive shock acceleration of cosmic rays by supernova remnants depends upon the generation of magnetic fluctuations by cosmic rays upstream of the shock. Strongly driven, ...non‐resonant, nearly purely growing modes grow more rapidly than the resonant Alfvén waves usually considered. Non‐linear simulation shows that the magnetic field can be amplified from its seed value by orders of magnitude. The consequences for the maximum attainable cosmic ray energy in supernova remnants are explored.
In the last 30 years, the contrast-to-noise ratio (CNR) has been used to estimate the contrast and lesion detectability in ultrasound images. Recent studies have shown that the CNR cannot be used ...with modern beamformers, as dynamic range alterations can produce arbitrarily high CNR values with no real effect on the probability of lesion detection. We generalize the definition of CNR based on the overlap area between two probability density functions. This generalized CNR (gCNR) is robust against dynamic range alterations; it can be applied to all kind of images, units, or scales; it provides a quantitative measure for contrast; and it has a simple statistical interpretation, i.e., the success rate that can be expected from an ideal observer at the task of separating pixels. We test gCNR on several state-of-the-art imaging algorithms and, in addition, on a trivial compression of the dynamic range. We observe that CNR varies greatly between the state-of-the-art methods, with improvements larger than 100%. We observe that trivial compression leads to a CNR improvement of over 200%. The proposed index, however, yields the same value for compressed and uncompressed images. The tested methods showed mismatched performance in terms of lesion detectability, with variations in gCNR ranging from -0.08 to +0.29. This new metric fixes a methodological flaw in the way we study contrast and allows us to assess the relevance of new imaging algorithms.
Interventional applications of photoacoustic imaging typically require visualization of point-like targets, such as the small, circular, cross-sectional tips of needles, catheters, or brachytherapy ...seeds. When these point-like targets are imaged in the presence of highly echogenic structures, the resulting photoacoustic wave creates a reflection artifact that may appear as a true signal. We propose to use deep learning techniques to identify these types of noise artifacts for removal in experimental photoacoustic data. To achieve this goal, a convolutional neural network (CNN) was first trained to locate and classify sources and artifacts in pre-beamformed data simulated with k-Wave. Simulations initially contained one source and one artifact with various medium sound speeds and 2-D target locations. Based on 3,468 test images, we achieved a 100% success rate in classifying both sources and artifacts. After adding noise to assess potential performance in more realistic imaging environments, we achieved at least 98% success rates for channel signal-to-noise ratios (SNRs) of -9dB or greater, with a severe decrease in performance below -21dB channel SNR. We then explored training with multiple sources and two types of acoustic receivers and achieved similar success with detecting point sources. Networks trained with simulated data were then transferred to experimental waterbath and phantom data with 100% and 96.67% source classification accuracy, respectively (particularly when networks were tested at depths that were included during training). The corresponding mean ± one standard deviation of the point source location error was 0.40 ± 0.22 mm and 0.38 ± 0.25 mm for waterbath and phantom experimental data, respectively, which provides some indication of the resolution limits of our new CNN-based imaging system. We finally show that the CNN-based information can be displayed in a novel artifact-free image format, enabling us to effectively remove reflection artifacts from photoacoustic images, which is not possible with traditional geometry-based beamforming.
Summary
The risk of type 2 diabetes among obese adults who are metabolically healthy has not been established. We systematically searched Medline (1946–August 2013) and Embase (1947–August 2013) for ...prospective studies of type 2 diabetes incidence (defined by blood glucose levels or self‐report) among metabolically healthy obese adults (defined by body mass index BMI and normal cardiometabolic clustering, insulin profile or risk score) aged ≥18 years at baseline. We supplemented the analysis with an original effect estimate from the English Longitudinal Study of Ageing (ELSA), with metabolically healthy obesity defined as BMI ≥ 30 kg m−2 and <2 of hypertension, impaired glycaemic control, systemic inflammation, adverse high‐density lipoprotein cholesterol and adverse triglycerides. Estimates from seven published studies and ELSA were pooled using random effects meta‐analyses (1,770 healthy obese participants; 98 type 2 diabetes cases). The pooled adjusted relative risk (RR) for incident type 2 diabetes was 4.03 (95% confidence interval = 2.66–6.09) in healthy obese adults and 8.93 (6.86–11.62) in unhealthy obese compared with healthy normal‐weight adults. Although there was between‐study heterogeneity in the size of effects (I2 = 49.8%; P = 0.03), RR for healthy obesity exceeded one in every study, indicating a consistently increased risk across study populations. Metabolically healthy obese adults show a substantially increased risk of developing type 2 diabetes compared with metabolically healthy normal‐weight adults. Prospective evidence does not indicate that healthy obesity is a harmless condition.
Galactic cosmic-ray (CR) acceleration to the knee in the spectrum at a few PeV is only possible if the magnetic field ahead of a supernova remnant (SNR) shock is strongly amplified by CRs escaping ...the SNR. A model formulated in terms of the electric charge carried by escaping CRs predicts the maximum CR energy and the energy spectrum of CRs released into the surrounding medium. We find that historical SNRs such as Cas A, Tycho and Kepler may be expanding too slowly to accelerate CRs to the knee at the present time.
RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse ...modification of messenger RNAs with N⁶-methyladenosine (m⁶A), 5-methylcytosine (m⁵C), and pseudouridine (ψ). Here we discuss the rapidly evolving understanding of the location, regulation, and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNA target sites are selected and how their modification is regulated. Diverse molecular consequences of individual m⁶A modifications are beginning to be revealed, but the effects of m⁵C and Ψ remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators.
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