Igf2 (insulin‐like growth factor 2) and H19 genes are imprinted in mammals; they are expressed unevenly from the two parental alleles. Igf2 is a growth factor expressed in most normal tissues, solely ...from the paternal allele. H19 gene is transcribed (but not translated to a protein) from the maternal allele. Igf2 protein is a growth factor particularly important during pregnancy, where it promotes both foetal and placental growth and also nutrient transfer from mother to offspring via the placenta. This article reviews epigenetic regulation of the Igf2/H19 gene‐cluster that leads to parent‐specific expression, with current models including parental allele‐specific DNA methylation and chromatin modifications, DNA‐binding of insulator proteins (CTCFs) and three‐dimensional partitioning of DNA in the nucleus. It is emphasized that key genomic features are conserved among mammals and have been functionally tested in mouse. ‘The enhancer competition model’, ‘the boundary model’ and ‘the chromatin‐loop model’ are three models based on differential methylation as the epigenetic mark responsible for the imprinted expression pattern. Pathways are discussed that can account for allelic methylation differences; there is a recent study that contradicts the previously accepted fact that biallelic expression is accompanied with loss of differential methylation pattern.
Nonresidential and mid- to high-rise multifamily residential structures in the United States currently use little wood per unit floor area installed, because earlier building codes lacked provisions ...for structural wood use in those types of buildings. However, revisions to the International Building Code allow for increased wood use in the form of mass timber, as structural and fire safety concerns have been addressed through new science-based design standards and through newly specified construction materials and measures. This study used multiple models to describe alternative futures for new construction, mass timber adoption rates, and the associated carbon benefits in higher than three-story buildings in the United States. The use of mass timber, in place of traditional constructions (i.e., structures dominated by concrete and steel), in projected new higher than three-story buildings was shown to provide combined carbon benefits (i.e., global warming mitigation benefits), including avoided embodied carbon emissions due to the substitution of non-wood alternatives and additional biogenic carbon storage in mass timber materials, of between 9.9 and 16.5 million t CO2e/yr spanning 50 years, 2020 to 2070. These carbon benefits equate to 12% to 20% of the total U.S. harvested wood products carbon storage for 2020. Future research is needed to understand how greater mass timber adoption leads to changes in forest product markets, land use, and total forest sector carbon.
The Telescope Array (TA) observatory utilizes fluorescence detectors and surface detectors (SDs) to observe air showers produced by ultra high energy cosmic rays in Earth's atmosphere. Cosmic-ray ...events observed in this way are termed hybrid data. The depth of air shower maximum is related to the mass of the primary particle that generates the shower. This paper reports on shower maxima data collected over 8.5 yr using the Black Rock Mesa and Long Ridge fluorescence detectors in conjunction with the array of SDs. We compare the means and standard deviations of the observed X max distributions with Monte Carlo X max distributions of unmixed protons, helium, nitrogen, and iron, all generated using the QGSJet II-04 hadronic model. We also perform an unbinned maximum likelihood test of the observed data, which is subjected to variable systematic shifting of the data X max distributions to allow us to test the full distributions, and compare them to the Monte Carlo to see which elements are not compatible with the observed data. For all energy bins, QGSJet II-04 protons are found to be compatible with TA hybrid data at the 95% confidence level after some systematic X max shifting of the data. Three other QGSJet II-04 elements are found to be compatible using the same test procedure in an energy range limited to the highest energies where data statistics are sparse.
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•CNC production on a commercial scale from wood pulp was explored for two scenarios.•Acid recovery process showed a better economic performance.•The MSP of 1 kg of CNC with acid ...recovery was $4.69.•Acid recovery process required more steam which increased fossil GHGs.
Cellulose nanocrystals (CNCs) are biobased materials with many desirable properties such as high aspect ratio, mechanical strength, crystalline nature, and biodegradability. This study developed a commercial-scale process model of CNC production from wood pulp using sulfuric acid treatment and evaluated its techno-economic and environmental performance with and without acid recovery. The results indicated that CNC produced with acid recovery process was financially more profitable with higher project net present values than without acid recovery process but required higher capital which resulted in a longer payback period and lower return on invested capital. The estimated minimum selling prices of CNC produced with and without acid recovery were $4.69/kg and $4.89/kg, respectively. The global warming (GW) impacts of 1 kg CNC production with and without acid recovery were 11.39 and 11.18 kgCO2eq, respectively, showing that higher steam use and consequently more fossil fuels were needed in the acid recovery process.
In the study of cosmic rays, the measurement of the energy spectrum of the primaries is one of the main issues and provides fundamental information on the most energetic phenomena in the Universe. At ...ultrahigh energies, beyond 10
18
eV, the cosmic rays are studied by the two largest observatories built so far, the Pierre Auger Observatory and the Telescope Array. Both observatories are based on a hybrid design and reported a measurement of the energy spectrum using the high duty cycle of the surface detector and the calorimetric estimation of the energy scale provided by the fluorescence detector.
The differences among the reported spectra are scrutinized by a working group made by members of the Pierre Auger and Telescope Array Collaborations. The two measurements have been found well in agreement below 10
19
eV while, at higher energies, they show an energy-dependent difference that is beyond the systematic uncertainties associated to the energy scale.
In this contribution we review the status and perspectives of the working group activities including new studies aiming at addressing the impact on the flux measurement at the highest energies of potential biases in the estimation of the shower size.
Buildings consume large amounts of materials and energy, making them one of the highest environmental impactors. Quantifying the impact of building materials can be critical to developing an ...effective greenhouse gas mitigation strategy. Using Athena Impact Estimator for Buildings (IE4B), this paper compares cradle-to-grave life-cycle assessment (LCA) results for a 12-story building constructed from cross-laminated timber (CLT) and a functionally equivalent reinforced concrete (RC) building. Following EN 15978 framework, environmental impacts for stages A1–A5 (product to construction), B2, B4, and B6 (use), C1–C4 (end of life), and D (beyond the building life) were evaluated in detail along resource efficiency. For material resource efficiency, total mass of the CLT building was 33.2% less than the alternative RC building. For modules A to C and not considering operational energy use (B6), LCA results show a 20.6% reduction in embodied carbon achieved for the CLT building, compared to the RC building. For modules A to D and not considering B6, the embodied carbon assessment revealed that for the CLT building, 6.57 × 105 kg CO2 eq was emitted, whereas for the equivalent RC building, 2.16 × 106 kg CO2 eq was emitted, and emissions from CLT building was 70% lower than that from RC building. Additionally, 1.84 × 106 kg of CO2 eq was stored in the wood material used in the CLT building during its lifetime. Building material selection should be considered for the urgent need to reduce global climate change impacts.
To improve consistency between register studies in Sweden and ensure valid comparisons of possible changes in alcohol-related disorders and diseases (ARDDs) over time, we propose a definition of ...ARDDs. Based on this definition, we examined Sweden's incidence rates of ARDDs from 1970 to 2018 in non-primary healthcare settings (inpatient and outpatient).
Swedish Society of Epidemiology members were invited to give feedback on the International Classification of Disease (ICD) codes with a potential link to alcohol use. We then calculated age-standardised and age-specific incidence of ARDDs over time according to the National Patient Register, and the lifetime prevalence of ARDDs diagnosed in adults alive in Sweden on Dec 31, 2018.
Sweden's estimated incidence of ARDDs increased substantially after introducing the new ICD-9 codes in 1987. In the past 10 years (2009-2018), the incidence of ARDDs has been stable (males: 110/100,000 person-years, females: 49/100,000 person-years). Requiring at least two ICD records for diagnosed ARDDs led to a somewhat lower incidence of ARDDs (males: 71 per 100,000 person-years, females: 29 per 100,000 person-years). In Sweden, the lifetime prevalence of diagnosed ARDDs in adults on Dec 31, 2018, was 1.9% (95% CI=1.9-1.9).
In this nationwide study, we found an incidence of ARDDs of 50-100/100,000 person-years. In 2018, 1 in 52 adults in Sweden had been diagnosed with ARDDs in the National Patient Register.
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