The Hubble Constant from SN Refsdal Vega-Ferrero, J.; Diego, J. M.; Miranda, V. ...
Astrophysical journal. Letters,
02/2018, Letnik:
853, Številka:
2
Journal Article
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Hubble Space Telescope observations from 2015 December 11 detected the expected fifth counter-image of supernova (SN) Refsdal at z = 1.49. In this Letter, we compare the time-delay predictions from ...numerous models with the measured value derived by Kelly et al. from very early data in the light curve of the SN Refsdal and find a best value for (68% CL), in excellent agreement with predictions from cosmic microwave background and recent weak lensing data + baryon acoustic oscillations + Big Bang nucleosynthesis (from the DES Collaboration). This is the first constraint on H0 derived from time delays between multiple-lensed SN images, and the first with a galaxy cluster lens, subject to systematic effects different from other time-delay H0 estimates. Additional time-delay measurements from new multiply imaged SNe will allow derivation of competitive constraints on H0.
Human glioblastomas harbour a subpopulation of glioblastoma stem cells that drive tumorigenesis. However, the origin of intratumoural functional heterogeneity between glioblastoma cells remains ...poorly understood. Here we study the clonal evolution of barcoded glioblastoma cells in an unbiased way following serial xenotransplantation to define their individual fate behaviours. Independent of an evolving mutational signature, we show that the growth of glioblastoma clones in vivo is consistent with a remarkably neutral process involving a conserved proliferative hierarchy rooted in glioblastoma stem cells. In this model, slow-cycling stem-like cells give rise to a more rapidly cycling progenitor population with extensive self-maintenance capacity, which in turn generates non-proliferative cells. We also identify rare 'outlier' clones that deviate from these dynamics, and further show that chemotherapy facilitates the expansion of pre-existing drug-resistant glioblastoma stem cells. Finally, we show that functionally distinct glioblastoma stem cells can be separately targeted using epigenetic compounds, suggesting new avenues for glioblastoma-targeted therapy.
The Dark Energy Survey Image Processing Pipeline Morganson, E.; Gruendl, R. A.; Menanteau, F. ...
Publications of the Astronomical Society of the Pacific,
07/2018, Letnik:
130, Številka:
989
Journal Article
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The Dark Energy Survey (DES) is a five-year optical imaging campaign with the goal of understanding the origin of cosmic acceleration. DES performs a ∼5000 deg2 survey of the southern sky in five ...optical bands (g, r, i, z, Y) to a depth of ∼24th magnitude. Contemporaneously, DES performs a deep, time-domain survey in four optical bands (g, r, i, z) over ∼27 deg2. DES exposures are processed nightly with an evolving data reduction pipeline and evaluated for image quality to determine if they need to be retaken. Difference imaging and transient source detection are also performed in the time domain component nightly. On a bi-annual basis, DES exposures are reprocessed with a refined pipeline and coadded to maximize imaging depth. Here we describe the DES image processing pipeline in support of DES science, as a reference for users of archival DES data, and as a guide for future astronomical surveys.
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