B cells have important functions in the pathogenesis of autoimmune diseases, including autoimmune rheumatic diseases. In addition to producing autoantibodies, B cells contribute to autoimmunity by ...serving as professional antigen-presenting cells (APCs), producing cytokines, and through additional mechanisms. B cell activation and effector functions are regulated by immune checkpoints, including both activating and inhibitory checkpoint receptors that contribute to the regulation of B cell tolerance, activation, antigen presentation, T cell help, class switching, antibody production and cytokine production. The various activating checkpoint receptors include B cell activating receptors that engage with cognate receptors on T cells or other cells, as well as Toll-like receptors that can provide dual stimulation to B cells via co-engagement with the B cell receptor. Furthermore, various inhibitory checkpoint receptors, including B cell inhibitory receptors, have important functions in regulating B cell development, activation and effector functions. Therapeutically targeting B cell checkpoints represents a promising strategy for the treatment of a variety of autoimmune rheumatic diseases.
Type Ia supernovae are key tools for measuring distances on a cosmic scale. They are generally thought to be the thermonuclear explosion of an accreting white dwarf in a close binary system. The ...nature of the mass donor is still uncertain. In the single-degenerate model it is a main-sequence star or an evolved star, whereas in the double-degenerate model it is another white dwarf. We show that the velocity structure of absorbing material along the line of sight to 35 type Ia supernovae tends to be blueshifted. These structures are likely signatures of gas outflows from the supernova progenitor systems. Thus, many type Ia supernovae in nearby spiral galaxies may originate in single-degenerate systems.
We present the fourth Fermi Large Area Telescope catalog (4FGL) of γ-ray sources. Based on the first eight years of science data from the Fermi Gamma-ray Space Telescope mission in the energy range ...from 50 MeV to 1 TeV, it is the deepest yet in this energy range. Relative to the 3FGL catalog, the 4FGL catalog has twice as much exposure as well as a number of analysis improvements, including an updated model for the Galactic diffuse γ-ray emission, and two sets of light curves (one-year and two-month intervals). The 4FGL catalog includes 5064 sources above 4 significance, for which we provide localization and spectral properties. Seventy-five sources are modeled explicitly as spatially extended, and overall, 358 sources are considered as identified based on angular extent, periodicity, or correlated variability observed at other wavelengths. For 1336 sources, we have not found plausible counterparts at other wavelengths. More than 3130 of the identified or associated sources are active galaxies of the blazar class, and 239 are pulsars.
We present observations of the possible short GRB 180418A in γ-rays, X-rays, and in the optical. Early optical photometry with the TAROT and RATIR instruments shows a bright peak ( 14.2 AB mag) ...between T + 28 and T + 90 s that we interpret as the signature of a reverse shock. Later observations can be modeled by a standard forward shock model and show no evidence of a jet break, allowing us to constrain the jet collimation to θj > 7°. Using deep late-time optical observations, we place an upper limit of r > 24 AB mag on any underlying host galaxy. The detection of the afterglow in the Swift UV filters constrains the GRB redshift to z < 1.3 and places an upper bound on the γ-ray isotropic equivalent energy Eγ,iso < 3 × 1051 erg. The properties of this GRB (e.g., duration, hardness ratio, energy, and environment) lie at the intersection between short and long bursts, and we cannot conclusively identify its type. We estimate that the probability that it is drawn from the population of short GRBs is 10%-30%.
We present observations and analysis of the host galaxies of 23 heavily dust-obscured gamma-ray bursts (GRBs) observed by the Swift satellite during the years 2005-2009, representing all GRBs with an ...unambiguous host-frame extinction of A sub(V) > 1 mag from this period. Deep observations with Keck, Gemini, Very Large Telescope, Hubble Space Telescope, and Spitzer successfully detect the host galaxies and establish spectroscopic or photometric redshifts for all 23 events, enabling us to provide measurements of the intrinsic host star formation rates, stellar masses, and mean extinctions. Compared to the hosts of unobscured GRBs at similar redshifts, we find that the hosts of dust-obscured GRBs are (on average) more massive by about an order of magnitude and also more rapidly star forming and dust obscured. While this demonstrates that GRBs populate all types of star-forming galaxies, including the most massive, luminous systems at z approximately 2, at redshifts below 1.5 the overall GRB population continues to show a highly significant aversion to massive galaxies and a preference for low-mass systems relative to what would be expected given a purely star-formation-rate-selected galaxy sample. This supports the notion that the GRB rate is strongly dependent on metallicity, and may suggest that the most massive galaxies in the universe underwent a transition in their chemical properties ~9 Gyr ago. We also conclude that, based on the absence of unobscured GRBs in massive galaxies and the absence of obscured GRBs in low-mass galaxies, the dust distributions of the lowest-mass and the highest-mass galaxies are relatively homogeneous, while intermediate-mass galaxies (~10 super(9) M sub(middot in circle)) have diverse internal properties.
ABSTRACT The rate of image acquisition in modern synoptic imaging surveys has already begun to outpace the feasibility of keeping astronomers in the real-time discovery and classification loop. Here ...we present the inner workings of a framework, based on machine-learning algorithms, that captures expert training and ground-truth knowledge about the variable and transient sky to automate (1) the process of discovery on image differences, and (2) the generation of preliminary science-type classifications of discovered sources. Since follow-up resources for extracting novel science from fast-changing transients are precious, self-calibrating classification probabilities must be couched in terms of efficiencies for discovery and purity of the samples generated. We estimate the purity and efficiency in identifying real sources with a two-epoch image-difference discovery algorithm for the Palomar Transient Factory (PTF) survey. Once given a source discovery, using machine-learned classification trained on PTF data, we distinguish between transients and variable stars with a 3.8% overall error rate (with 1.7% errors for imaging within the Sloan Digital Sky Survey footprint). At >96% classification efficiency, the samples achieve 90% purity. Initial classifications are shown to rely primarily on context-based features, determined from the data itself and external archival databases. In the first year of autonomous operations of PTF, this discovery and classification framework led to several significant science results, from outbursting young stars to subluminous Type IIP supernovae to candidate tidal disruption events. We discuss future directions of this approach, including the possible roles of crowdsourcing and the scalability of machine learning to future surveys such as the Large Synoptic Survey Telescope (LSST).
The localization of the short-duration, hard-spectrum gamma-ray burst GRB 050509b by the Swift satellite was a watershed event. We report the discovery of the probable host galaxy, a bright ...elliptical galaxy at z = 0.2248. This is the first known redshift and host of a short-hard GRB and shows that at least some short-hard GRBs are cosmological in origin. We began imaging the GRB field 8 minutes after the burst and continued for 8 days. We present a reanalysis of the XRT afterglow and report the absolute position of the GRB. Based on positional coincidences, the GRB and the elliptical are likely to be physically related, unlike any known connection between a long-duration GRB and an early-type galaxy. Similarly unique, GRB 050509b likely also originated from within a rich cluster of galaxies with detectable diffuse X-ray emission. We demonstrate that while the burst was underluminous, the ratio of the blast wave energy to the g-ray energy is consistent with that of long-duration GRBs. Based on this analysis, on the location of the GRB (40 c13 kpc from the putative host), on the galaxy type (elliptical), and the lack of a coincident supernova, we suggest that there is now observational support for the hypothesis that short-hard bursts arise during the merger of a compact binary. We limit the properties of any Li-Paczynski "minisupernova" that is predicted to arise on 61 day timescales. Other progenitor models are still viable, and new Swift bursts will undoubtedly help to further clarify the progenitor picture.
We present the volumetric rate of normal type Ia supernovae (SNe Ia) discovered by the
Palomar Transient Factory (PTF). Using strict data-quality cuts, and considering only periods when the PTF ...maintained a regular cadence, PTF discovered 90 SNe Ia at z ≤ 0.09 in a well-controlled sample over three years of operation (2010–2012). We use this to calculate the volumetric rate of SN Ia events by comparing this sample to simulations of hundreds of millions of SN Ia light curves produced in statistically representative realizations of the PTF survey. This quantifies the recovery efficiency of each PTF SN Ia event, and thus the relative weighting of each event. From this, the volumetric SN Ia rate was found to be r(v) = 2.43 ± 0.29 (stat)(+0.33,−0.19)(sys) × 10^(−5) SNe per yr Mpc^(-3) h(3,70). This represents the most precise local measurement of the SNIa rate. We fit a simple SNIa delay-time distribution model, ∝ t^(−β) , to our PTF rate measurement combined with a literature sample of rate measurements from surveys at higher redshifts. We find β ∼ 1, consistent with a progenitor channel governed by the gravitational inspiral of binary white dwarfs.
Abstract
We present analysis of the light curves (LCs) of 77 hydrogen-poor superluminous supernovae (SLSNe I) discovered during the Zwicky Transient Facility Phase I operation. We find that the ...majority (67%) of the sample can be fit equally well by both magnetar and ejecta–circumstellar medium (CSM) interaction plus
56
Ni decay models. This implies that LCs alone cannot unambiguously constrain the physical power sources for an SLSN I. However, 23% of the sample show inverted V-shape, steep-declining LCs or features of long rise and fast post-peak decay, which are better described by the CSM+Ni model. The remaining 10% of the sample favors the magnetar model. Moreover, our analysis shows that the LC undulations are quite common, with a fraction of 18%–44% in our gold sample. Among those strongly undulating events, about 62% of them are found to be CSM-favored, implying that the undulations tend to occur in the CSM-favored events. Undulations show a wide range in energy and duration, with median values (and 1
σ
errors) being as
1.7
%
−
0.7
%
+
1.5
%
E
rad
,
total
and
28.8
−
9.1
+
14.4
days, respectively. Our analysis of the undulation timescales suggests that intrinsic temporal variations of the central engine can explain half of the undulating events, while CSM interaction (CSI) can account for the majority of the sample. Finally, all of the well-observed He-rich SLSNe Ib either have strongly undulating LCs or the LCs are much better fit by the CSM+Ni model. These observations imply that their progenitor stars have not had enough time to lose all of the He-envelopes before supernova explosions, and H-poor CSM are likely to present in these events.
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