Influence of intraperitoneal administration of polygalacturonic acid derivatives at a dose of 100 mg/kg on the glutathione system and lipid peroxidation in the rat lung after treatment with NO2 was ...studied. A considerable decrease of lipid peroxidation intensity by these derivatives was caused not only by ability of these compounds to the chelate formation and absorption of free radicals, but also by the substantial activation of the glutathione system.
Integral operators that translate arbitrary functions into regular solutions of a hyperbolic equation of second and higher orders are constructed. The Cauchy problem for the fourth-order hyperbolic ...equation is solved. The use of the theory of special functions made it possible to present solutions of partial derivative equations in a form convenient for the analysis. Along the way, integral convolution equations with special functions in the kernel are solved.
Arc-melted Ti
100–x
Mo
2
Al
x
alloys (where x is 44, 46, 48, and 50 at.% Al) that were produced from pure components were examined by X-ray diffraction and scanning electron microscopy with electron ...microprobe analysis (SEM/EDX). The melting points and solid-phase transformations were studied by differential thermal analysis (DTA) and the mechanical properties by fracture toughness, bending, and compression tests. The CALPHAD approach was used for thermodynamic calculation of phase equilibria in the composition region under study. The cast alloys mainly consist of a lamellar structure formed by lamellas of γ-TiAl and α
2
-Ti
3
Al phases with submicron thickness and a cubic Ti
55
Mo
4
–6Al
39–40
phase of A2 type (β) or B2 type (β0). In the γ-TiAl-based alloys, molybdenum behaves as a low-melting dopant, enriching the grain periphery. The standard mechanical characteristics of the alloys were determined and their structural sensitivity was analyzed. All studied alloys demonstrate excellent high-temperature strength. The yield stress is 400–600 MPa in the temperature range 20–750°C. The strength slightly increases at 300 and 600°C under dynamic strain ageing. The strain hardening parameters were established over a wide range of test temperatures. The temperature dependence of the strain hardening coefficient and strain hardening index was analyzed for alloys in different phase and structural states. In the temperature range from 20 to 600°C, the strain hardening index and coefficient were found to vary slightly. The strain hardening index increased from n = 0.6 to n = 0.95 with aluminum content changing from 44 to 50 at.%, which indicates that the strain hardening mechanism changes with variation in the alloy phase constituents.
A reusable system for phenol determination in an aqueous medium was obtained by adsorption of extracellular oxidase from fungus
Neonothopanus nambi
onto modified nanodiamonds (MND) synthesized by ...detonation. It was found that the enzyme strongly binds to MND and exhibits catalytic activity in the reaction of co-oxidation of phenol with 4-aminoantipyrine without the addition of hydrogen peroxide. In the presence of the MND–oxidase complex, a significantly (by an order of magnitude) higher yield of the reaction product is recorded as compared to the yield in the presence of a free enzyme; the mechanism of the revealed effect is discussed. Model experiments have demonstrated the multiple use of the MND–oxidase complex for testing phenol in aqueous samples. The immobilized enzyme exhibits functional activity during long-term (2 months) storage of the MND–oxidase complex at 4°C. The data obtained create the prerequisites for using the created system in environmental monitoring of water pollution with phenol.
This research deals with the Portland cement hydration processes in the presence of chemical additives. The slag-alkyne binders based on bottom ash are under investigation. It has been solved the ...problem of utilization the wastes from the thermal power plants. The components of slag-alkyne binders have been tested, normal gravity of cement mixture with the additives has been determined, and cement mixture curing period was measured. The possibility of deriving the ash-slag binders of the thermal power plant wastes was discovered. The methods of mathematical experiment planning were applied to assess the influence levels of chemical additives on the properties of alkyne-slag binders. The presented results provide the thermal power plants with a solution to how the industrial wastes can be disposed of in an environmentally friendly fashion. The spreadsheets with research data are provided along with the equations for the binders' properties correlation with the number of chemical additives used and its fraction in the total composition.
The electronic width of the
J
/
ψ
meson and its product by the branching fractions of
J
/
ψ
meson decay to hadrons and electrons measured with the KEDR detector at the VEPP-4M
e
+
e
−
collider have ...been reported in ref. 1.
Aquaporins (AQPs) belong to a transmembrane protein family of water channels that are permeable to water by the osmotic gradient. There are two isoforms of mouse AQP4 — M1 and M23. Their balance in ...the cell determines water permeability of the plasma membrane. These two isoforms are encoded by three mRNAs: M1 isoform is encoded by M1 mRNA and M23 isoform is encoded by M23 and M23X mRNAs. Here we found a new fourth mRNA of mouse AQP4 — M23A mRNA. The start of transcription is different for M23A mRNA from all the known AQP4 mRNAs. The 5′-untranslated region (5′-UTR) of M23A mRNA is encoded by four new exons (A, B, C, and D), which are located in the 5′ region from exon-0 of the
AQP4
gene. Alternative splicing between the exons-A, -B, -C, and -D leads to formation of multiple variants of M23A mRNA. We cloned six of these variants, all of which code full length M23 isoform of AQP4. Using RT-PCR we detected tissue-specific expression of the new M23A and already known M23, M23X, and M1 mRNAs. The M23A mRNA is expressed mostly in kidney, liver, and brain. Analysis of mRNA 5′-UTR structure showed low translation efficacy for M1 mRNA in comparison with high translation efficacy for M23A, M23X, and M23 mRNAs. We propose that AQP4 expression is controlled tissue-specifically by independent promoters. Thus multiple AQP4 mRNAs may allow long-term regulation of the balance between M1 and M23 AQP4 isoforms in the cell and thus water permeability of the plasma membrane.
A novel thermophilic bacteriophage AP45 and its host strain
Aeribacillus
sp. CEMTC656 were isolated from the Valley of Geysers, Kamchatka Peninsula, Russia. Bacteriophage AP45 was identified as a ...member of the
Siphoviridae
family by electron microscopy. It showed high thermostability and had a slow cycle of reproduction. The AP45 genome had 51,606 base pairs (bp) and contained 71 open reading frames (ORFs), 40 of them encoding proteins of predicted function. Genes encoding DNA and RNA polymerases were not identified, indicating that AP45 used host polymerases. Based on the ORF65 encoding putative endolysin, the recombinant protein rAP45Lys was developed and its peptidoglycan-hydrolyzing activity was demonstrated. The AP45 genome exhibited limited identity to other phage sequences; the highest identity, 36%, was with the genome of the thermophilic
Geobacillus
myovirus D6E. The majority of putative proteins encoded by the AP45 genome had higher similarity to proteins from bacteria belonging to the
Bacillaceae
family, than to bacteriophages. In addition, more than half of the putative ORFs in the AP45 genome were highly similar to prophage sequences of
A. pallidus
strain 8m3, which was isolated in north–east China. The AP45 phage and revealed prophages might be members of a new genus belonging to the
Siphoviridae
family.
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