Cutaneous asthenia (Ehlers–Danlos syndrome) in a cat DOKUZEYLÜL, Banu; ALTUN, Elif Demet; ÖZDOĞAN, Tamer Halit
Turkish Journal of Veterinary and Animal Sciences; Year: 2013 Volume: 37 Issue: 2; 245-249,
01/2013
Journal Article
Recenzirano
Odprti dostop
Ehlers-Danlos syndrome (EDS), or dermatosparaxis, is a rare hereditary disease of the connective tissue, which is characterized by skin hyperextensibility and laxity. In the present article, the case ...of a crossbred female spayed cat, at the age of 2 years, was presented with hyperelasticity of the skin, alopecia, and an ulcerative wound on the left hind leg. The animal's dorsum was hyperextensible, smooth to the touch, and could be easily torn with minor traumas. To the best of the authors' knowledge, the present report is the first documented feline case of cutaneous asthenia in Turkey.
Patients with Su Type III fractures based on total knee arthroplasty (TKA) constitute a patient group with problematic treatment and management. Although it has difficulties, open reduction and ...internal fixation is one of the treatment options.
A retrospective evaluation was made of 22 patients surgically treated in our clinic with double locking, low contact titanium plate and screw for a Su Type III periprosthetic fracture based on TKA. The patients were evaluated with bone mineral densitometry, postoperative Knee Society Score (KSS), WOMAC and radiological evaluations.
The mean follow-up period of the patients was 68.6 ± 15.5 months, with pain-free weight-bearing determined at 4.9 ± 1.1 months and mean radiological union at 18.5 ± 4.3 weeks. Revision was required because of non-union in 2 (9.09%) cases. The postoperative KSS value was 81.8 ± 7.8, the WOMAC value was 78.1 ± 5.3 and the T-score was −3.3 ± 0.3. At the final follow-up examination, a correction loss (4.9° ± 1.5°) was determined in the mean knee valgus angle according to the mechanical axis, which was statistically significant but remained within the physiological limits (p = 0.21).
In addition to providing the advantages of rigid fixation together with early and effective rehabilitation, satisfactory clinical and radiological results were obtained with the application of double locking plate and screw in the treatment of periprosthetic femoral fractures based on TKA, with osteoporosis.
Level IV, Therapeutic study.
Istražena je lokalizacija i proširenost antigena virusa virusnog proljeva goveda u tkivima spolnog sustava 65 negravidnih mliječnih krava i 65 bikova. U tu svrhu rabljen je imunoperoksidazni test na ...histološkim rezovima tkiva. Tom metodom pretraženi su uzorci tkiva spolnih organa uzeti od zdravih zaklanih bikova te krava s reprodukcijskim poremećajima. Virusni antigeni dokazani su u 15 od 65 krava (sukladno s uzgojem virusa na staničnoj kulturi). Antigeni su bili prisutni u makrofagima sličnim stanicama unutar strome jajnika i maternice. Virusni antigeni nisu dokazani u uzorcima tkiva testisa, epididimisa, sjemene vrećice i prostate bikova. U pretraženih životinja, uključujući i one pozitivne na virus, nisu zabilježene patološke promjene, osim povremenih nespecifičnih subepitelijalnih ili stromalnih mononuklearnih infiltracija limfocitima i makrofagima.
Cisplatin-paclitaxel and bevacizumab is a frequently used treatment regimen for metastatic or recurrent cervical cancer, and carboplatin-paclitaxel and bevacizumab are also among the recommended ...regimens. In this study we aimed to evaluate the efficacy of these two regimens for the treatment of metastatic or recurrent cervical cancer.
Patients with metastatic or recurrent cervical cancer treated with cisplatin-paclitaxel and bevacizumab or carboplatin-paclitaxel and bevacizumab were retrospectively evaluated in this study. The clinical and demographic characteristics of patients in each group were evaluated. Median overall survival, progression-free survival, and response rates between the two groups were compared.
A total of 250 patients were included. Overall, the numbers of patients with recurrent disease and metastatic disease were 159 and 91, respectively. The most common histologic subtype was squamous cell carcinoma (83.2%). The median duration of follow-up was 13.6 (range 0.5-86) months. The median progression-free survival was 10.5 (95% CI 9.0 to 11.8) months in the cisplatin-paclitaxel and bevacizumab group (group 1), and 10.8 (95% CI 8.6 to 13.0) months in the carboplatin-paclitaxel and bevacizumab group (group 2) (HR 1.20; 95% CI 0.88 to 1.63; p=0.25). The median overall survival was 19.1 (95% CI 13.0 to 25.1) months in group 1 and 18.3 (95% CI 15.3 to 21.3) months in group 2 (HR 1.28; 95% CI 0.91 to 1.80; p=0.15).
There is no survival difference between cisplatin or carboplatin combined with paclitaxel and bevacizumab in metastatic or recurrent cervical cancer.
This study intends to explore the current trends in the field of distance education research during the period of 2009-2013. The trends were identified by an extensive review of seven peer reviewed ...scholarly journals: The American Journal of Distance Education (AJDE), Distance Education (DE), The European Journal of Open, Distance and e-Learning (EURODL), The Journal of Distance Education (JDE), The Journal of Online Learning and Technology (JOLT), Open Learning: The Journal of Open, Distance and e-Learning (OL) and The International Review of Research in Open and Distributed Learning (IRRODL). A total of 861 research articles was reviewed. Mainly content analysis was employed to be able to analyze the current research. Also, a social network analysis (SNA) was used to interpret the interrelationship between keywords indicated in these articles. Themes were developed and the content of the articles in the selected journals were coded according to categories derived from earlier studies. The results were interpreted using descriptive analysis (frequencies) and social network analysis. The reporting of the results were organized into the following categories: research areas, theoretical and conceptual frameworks, variables, methods, models, strategies, data collection and analysis methods, and the participants. The study also identified the most commonly used keywords, and the most frequently cited authors and studies in distance education. The findings obtained in this study may be useful in the exploration of potential research areas and identification of neglected areas in the field of distance education.
To document the clinical and paraclinical features of pediatric multiple sclerosis (MS) in Turkey.
Data of MS patients with onset before age 18 years (n = 193) were collected from 27 pediatric ...neurology centers throughout Turkey. Earlier-onset (<12 years) and later-onset (≥12 years) groups were compared.
There were 123 (63.7%) girls and 70 (36.3%) boys aged 4–17 years, median 14 years at disease onset. Family history of MS was 6.5%. The first presentation was polysymptomatic in 55.4% of patients, with brainstem syndromes (50.3%), sensory disturbances (44%), motor symptoms (33.2%), and optic neuritis (26.4%) as common initial manifestations. Nineteen children had facial paralysis and 10 had epileptic seizures at first attack; 21 (11%) were initially diagnosed with acute disseminated encephalomyelitis (ADEM). Oligoclonal bands were identified in 68% of patients. Magnetic resonance imaging revealed periventricular (96%), cortical/juxtacortical (64.2%), brainstem (63%), cerebellum (51.4%), and spinal cord (67%) involvement. Visual evoked potentials (VEP) were abnormal in 52%; serum 25-hydroxyvitamin D levels were low in 68.5% of patients. The earlier-onset group had a higher rate of infection/vaccination preceding initial attack, initial diagnosis of ADEM, longer interval between first 2 attacks, and more disability accumulating in the first 3 years of the disease.
Brainstem and cerebellum are common sites of clinical and radiological involvement in pediatric-onset MS. VEP abnormalities are frequent even in patients without history of optic neuropathy. Vitamin D status does not appear to affect the course in early disease. MS beginning before 12 years of age has certain characteristics in history and course.
•This study confirms pediatric MS is a predominantly relapsing-remitting disease.•Brainstem-cerebellar or ADEM-like symptoms, facial paralysis, seizures are frequent.•Onset with sensorial symptoms is less likely compared to later-onset MS.•High rates of vitamin D deficiency and subclinical VEP abnormalities are of note.•First inter-attack interval is longer, disability accumulates faster in early-onset MS.
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