This paper is dedicated to the study of the relationship between the Nd2NiO4+δ powder micro-structural properties (especially particle size and crystallinity) and electrochemical properties when the ...oxide is used as SOFC cathode deposited on 8YSZ electrolyte coated with thin doped ceria. Nano-structured particles of Nd2NiO4+δ with controlled crystallinity, size and morphology have been synthesized using ultrasonic spray pyrolysis (USP). The series and polarization resistances measured on symmetrical half cells Nd2NiO4+δ/YDC/8YSZ/YDC/Nd2NiO4+δ are both found to be dependent on the cathode microstructure and present a similar evolution with temperature. The best results are obtained for highly crystalline cathode powders combined with a small particle size.
Results are presented for six nuclei from Be to Pb on the structure function ratios
F
2
A/
F
2
C(
x) and their
A dependence in deep inelastic muon scattering at 200 GeV incident muon energy. The data ...cover the kinematic range 0.01 <
x < 0.8 with
Q
2 ranging from 2 to 70 GeV
2. The
A dependence of nuclear structure function ratios is parametrised and compared to various models.
A series of semi-inclusive deep-inelastic scattering measurements on deuterium, helium, neon, krypton, and xenon targets has been performed in order to study hadronization. The data were collected ...with the HERMES detector at the DESY laboratory using a 27.6 GeV positron or electron beam. Hadron multiplicities on nucleus
A relative to those on the deuteron,
R
A
h
, are presented for various hadrons (
π
+
,
π
−
,
π
0
,
K
+
,
K
−
,
p, and
p
¯
) as a function of the virtual-photon energy
ν, the fraction
z of this energy transferred to the hadron, the photon virtuality
Q
2
, and the hadron transverse momentum squared
p
t
2
. The data reveal a systematic decrease of
R
A
h
with the mass number
A for each hadron type
h. Furthermore,
R
A
h
increases (decreases) with increasing values of
ν (
z), increases slightly with increasing
Q
2
, and is almost independent of
p
t
2
, except at large values of
p
t
2
. For pions two-dimensional distributions also are presented. These indicate that the dependences of
R
A
π
on
ν and
z can largely be described as a dependence on a single variable
L
c
, which is a combination of
ν and
z. The dependence on
L
c
suggests in which kinematic conditions partonic and hadronic mechanisms may be dominant. The behaviour of
R
A
π
at large
p
t
2
constitutes tentative evidence for a partonic energy-loss mechanism. The
A-dependence of
R
A
h
is investigated as a function of
ν,
z, and of
L
c
. It approximately follows an
A
α
form with
α
≈
0.5
–
0.6
.
Landscapes can be understood as socialecological systems under constant change. In Europe various territorial dynamics pose persistent challenges to maintaining diverse landscapes both as European ...heritage and in their capacity to provide vital functions and services. Concurrently, under the competence of cohesion policy, the EU is attempting to improve policy making by better policy coordination and respecting regional specifics. This paper explores the question how a policy dedicated to landscape can help to handle territorial change and support territorial cohesion. It presents results and performances of the ESPON applied research study LP3LP: (1) a common landscape policy for the Three Countries Park, across the Dutch, German and Belgium borders, including a spatial landscape vision, a governance proposal of adaptive landscape management, and thematic strategies dealing with green infrastructure, cultural heritage, complementary biomass and quality production; (2) recommendations at the EU level. In discussing the significance of a landscape approach for EU policy,three dimensions of landscape are linked withimportant aspects of territorial cohesion: ‘landscape as asset’ addressing natural-cultural territorial capital as an indigenous base forsmart, sustainable, and inclusivedevelopment;‘landscape as place’ stressing the relevance of landscape for place-based policies; and ‘landscape as common ground’ highlighting its potential for horizontal, vertical, and territorial integration.
LMNA mutations induce a group of disorders called laminopathies, mainly affecting striated muscles. In the case of LMNA-related Congenital Muscular Dystrophy (L-CMD), it is the most severe form of ...striated muscle laminopathy with cardiomyopathy. We previously reported the phenotype of KI- LmnadelK32 mouse model mimicking a human LMNA mutation. This mouse model developed L-CMD phenotype at the homozygous state and isolated dilated cardiomyopathy at the heterozygous state. Taking the advantage of our mouse model, we have previously shown that the pathomechanism of the diseases involves both the expression of toxic mutant lamin A/C and lamin A/C decreased expression. Based on these pathophysiological observations, we aim at assessing a therapeutic approach that both reduces the expression of the mutant protein and restores the normal lamin A/C level. We produced AAV2/9 vectors containing human mature lamin A under control of a CMV promoter, either alone, or in combination with shRNA specifically targeting p.K32del Lmna mRNA or WT and mutated allele under a H1 promoter. Systemic administration in homozygous new-born mice resulted in a significant increase of their maximal survival after treatment, and important increase of lamin A/C protein level, reaching or overpassing lamin A/C level observed in wild type hearts. By contrast, despite an increased expression of human lamin A mRNA and protein in heterozygous mouse hearts, we did not observe any improvement in terms of survival or cardiac function after treatment. The absence of therapeutic benefit at long term is neither due to a loss of AAV genome particle nor to a loss of its expression with time. Rather, it is due to the absence of mouse Lmna mRNA knock-down and side effect in the liver strongly targeted by AAV2/9. Further development of our gene therapy will include new design, new promoters and AAV capsids to increase mouse Lmna mRNA knock-down and tissue specificity.
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