Mortality in very low birth weight infants following microbiology confirmed primary bloodstream infections varies with the type of causative pathogen. Given evidence from other studies that ...infections with gram negative bacteria and fungi cause a higher case fatality risk. We tried to confirm this in a nation-wide multi-center trial.
A cohort of 55,465 very low birth weight infants from 242 neonatal departments participating in the German national neonatal infection surveillance system NEO-KISS was used to investigate differences in the case fatality risk of microbiology confirmed primary bloodstream infections according to individual pathogens. Cox proportional hazard regression analyses were performed with the outcomes death and time from microbiology confirmed primary bloodstream infections. The results were adjusted to the recorded risk factors and hospital and department characteristics.
A total of 4 094 very low birth weight infants with microbiology confirmed primary bloodstream infections were included in the analysis. The crude case fatality risk was 5.7%. The Cox proportional hazard regression analysis with adjustment for available risk factors revealed that microbiology confirmed primary bloodstream infections caused by Klebsiella spp. (HR 3.17 CI95 1.69-5.95), Enterobacter spp. (HR 3.42 CI95 1.86-6.27), Escherichia coli (HR 3.32 CI95 1.84-6.00) and Serratia spp. (HR 3.30 CI95 1.44-7.57) were associated with significantly higher case fatality risk compared to Staphylococcus aureus. After adjusting, case fatality risk of Candida albicans causing microbiology confirmed primary bloodstream infections was not higher than that of S. aureus.
In very low birth weight infants, bloodstream infections caused by gram negative pathogens have an increased case fatality risk compared to bloodstream infections caused by gram positive pathogens. This should be considered for prevention and therapy. Further research should address the specific risk factors for case fatality of C. albicans bloodstream infections.
We report on the discovery of eight repeating fast radio burst (FRB) sources found using the Canadian Hydrogen Intensity Mapping Experiment (CHIME) telescope. These sources span a dispersion measure ...(DM) range of 103.5-1281 pc cm−3. They display varying degrees of activity: six sources were detected twice, another three times, and one 10 times. These eight repeating FRBs likely represent the bright and/or high-rate end of a distribution of infrequently repeating sources. For all sources, we determine sky coordinates with uncertainties of ∼10′. FRB 180916.J0158+65 has a burst-averaged DM = 349.2 0.3 pc cm−3 and a low DM excess over the modeled Galactic maximum (as low as ∼20 pc cm−3); this source also has a Faraday rotation measure (RM) of −114.6 0.6 rad m−2, which is much lower than the RM measured for FRB 121102. FRB 181030.J1054+73 has the lowest DM for a repeater, 103.5 0.3 pc cm−3, with a DM excess of ∼70 pc cm−3. Both sources are interesting targets for multi-wavelength follow-up due to their apparent proximity. The DM distribution of our repeater sample is statistically indistinguishable from that of the first 12 CHIME/FRB sources that have not yet repeated. We find, with 4 significance, that repeater bursts are generally wider than those of CHIME/FRB bursts that have not repeated, suggesting different emission mechanisms. Many of our repeater events show complex morphologies that are reminiscent of the first two discovered repeating FRBs. The repetitive behavior of these sources will enable interferometric localizations and subsequent host galaxy identifications.
We report on the discovery and analysis of bursts from nine new repeating fast radio burst (FRB) sources found using the Canadian Hydrogen Intensity Mapping Experiment (CHIME) telescope. These ...sources span a dispersion measure (DM) range of 195-1380 pc cm−3. We detect two bursts from three of the new sources, three bursts from four of the new sources, four bursts from one new source, and five bursts from one new source. We determine sky coordinates of all sources with uncertainties of ∼10′. We detect Faraday rotation measures (RMs) for two sources, with values −20(1) and −499.8(7) rad m−2, that are substantially lower than the RM derived from bursts emitted by FRB 121102. We find that the DM distribution of our events, combined with the nine other repeaters discovered by CHIME/FRB, is indistinguishable from that of thus far non-repeating CHIME/FRB events. However, as previously reported, the burst widths appear statistically significantly larger than the thus far non-repeating CHIME/FRB events, further supporting the notion of inherently different emission mechanisms and/or local environments. These results are consistent with previous work, though are now derived from 18 repeating sources discovered by CHIME/FRB during its first year of operation. We identify candidate galaxies that may contain FRB 190303.J1353+48 (DM = 222.4 pc cm−3).
The Canadian Hydrogen Intensity Mapping Experiment (CHIME) is a novel transit radio telescope operating across the 400-800 MHz band. CHIME is composed of four 20 m × 100 m semicylindrical paraboloid ...reflectors, each of which has 256 dual-polarization feeds suspended along its axis, giving it a 200 deg2 field of view. This, combined with wide bandwidth, high sensitivity, and a powerful correlator, makes CHIME an excellent instrument for the detection of fast radio bursts (FRBs). The CHIME Fast Radio Burst Project (CHIME/FRB) will search beam-formed, high time and frequency resolution data in real time for FRBs in the CHIME field of view. Here we describe the CHIME/FRB back end, including the real-time FRB search and detection software pipeline, as well as the planned offline analyses. We estimate a CHIME/FRB detection rate of 2-42 FRBs sky-1 day-1 normalizing to the rate estimated at 1.4 GHz by Vander Wiel et al. Likely science outcomes of CHIME/FRB are also discussed. CHIME/FRB is currently operational in a commissioning phase, with science operations expected to commence in the latter half of 2018.
We report the detection of a single burst from the first-discovered repeating fast radio burst (FRB) source, FRB 121102, with the Canadian Hydrogen Intensity Mapping Experiment (CHIME) telescope, ...which operates in the frequency band 400-800 MHz. The detected burst occurred on 2018 November 19 and its emission extends down to at least 600 MHz, the lowest frequency detection of this source yet. The burst, detected with a significance of 23.7 , has fluence 12 3 Jy ms and shows complex time and frequency morphology. The 34 ms width of the burst is the largest seen for this object at any frequency. We find evidence of subburst structure that drifts downward in frequency at a rate of −3.9 0.2 MHz ms−1. Our best fit tentatively suggests a dispersion measure of 563.6 0.5 pc cm−3, which is 1% higher than previously measured values. We set an upper limit on the scattering time at 500 MHz of 9.6 ms, which is consistent with expectations from the extrapolation from higher-frequency data. We have exposure to the position of FRB 121102 for a total of 11.3 hr within the FWHM of the synthesized beams at 600 MHz from 2018 July 25 to 2019 February 25. We estimate on the basis of this single event an average burst rate for FRB 121102 of 0.1-10 per day in the 400-800 MHz band for a median fluence threshold of 7 Jy ms in the stated time interval.
Abstract
We present a framework for modeling astrophysical pulses from radio pulsars and fast radio bursts (FRBs). This framework, called
fitburst
, generates synthetic representations of dynamic ...spectra that are functions of several physical and heuristic parameters; the heuristic parameters can nonetheless accommodate a vast range of distributions in spectral energy.
fitburst
is designed to optimize the modeling of features induced by effects that are intrinsic and extrinsic to the emission mechanism, including the magnitude and frequency dependence of pulse dispersion and scatter broadening.
fitburst
removes intrachannel smearing through two-dimensional upsampling, and can account for phase-wrapping of “folded” signals that are typically acquired during pulsar-timing observations. We demonstrate the effectiveness of
fitburst
in modeling data containing pulsars and FRBs observed with the Canadian Hydrogen Intensity Mapping Experiment telescope.
We report on the detection of seven bursts from the periodically active, repeating fast radio burst (FRB) source FRB 180916.J0158+65 in the 300-400 MHz frequency range with the Green Bank Telescope ...(GBT). Emission in multiple bursts is visible down to the bottom of the GBT band, suggesting that the cutoff frequency (if it exists) for FRB emission is lower than 300 MHz. Observations were conducted during predicted periods of activity of the source, and had simultaneous coverage with the Low Frequency Array (LOFAR) and the FRB backend on the Canadian Hydrogen Intensity Mapping Experiment (CHIME) telescope. We find that one of the GBT-detected bursts has potentially associated emission in the CHIME band (400-800 MHz) but we detect no bursts in the LOFAR band (110-190 MHz), placing a limit of on the spectral index of broadband emission from the source. We also find that emission from the source is severely band-limited with burst bandwidths as low as ∼40 MHz. In addition, we place the strictest constraint on observable scattering of the source, <1.7 ms at 350 MHz, suggesting that the circumburst environment does not have strong scattering properties. Additionally, knowing that the circumburst environment is optically thin to free-free absorption at 300 MHz, we find evidence against the association of a hyper-compact H ii region or a young supernova remnant (age <50 yr) with the source.
Abstract
The Canadian Hydrogen Intensity Mapping Experiment (CHIME) has become a leading facility for detecting fast radio bursts (FRBs) through the CHIME/FRB backend. CHIME/FRB searches for fast ...transients in polarization-summed intensity data streams that have 24 kHz spectral and 1 ms temporal resolution. The intensity beams are pointed to predetermined locations in the sky. A triggered baseband system records the coherent electric field measured by each antenna in the CHIME array at the time of FRB detections. Here we describe the analysis techniques and automated pipeline developed to process these full-array baseband data recordings. Whereas the real-time FRB detection pipeline has a localization limit of several arcminutes, offline analysis of baseband data yields source localizations with subarcminute precision, as characterized by using a sample of pulsars and one repeating FRB with known positions. The baseband pipeline also enables resolving temporal substructure on a microsecond scale and the study of polarization including detections of Faraday rotation.
Abstract
Polarimetric observations of fast radio bursts (FRBs) are a powerful resource for better understanding these mysterious sources by directly probing the emission mechanism of the source and ...the magneto-ionic properties of its environment. We present a pipeline for analyzing the polarized signal of FRBs captured by the triggered baseband recording system operating on the FRB survey of The Canadian Hydrogen Intensity Mapping Experiment (CHIME/FRB). Using a combination of simulated and real FRB events, we summarize the main features of the pipeline and highlight the dominant systematics affecting the polarized signal. We compare parametric (QU-fitting) and non-parametric (rotation measure synthesis) methods for determining the Faraday rotation measure (RM) and find the latter method susceptible to systematic errors from known instrumental effects of CHIME/FRB observations. These errors include a leakage artifact that appears as polarized signal near RM ∼ 0 rad m
−2
and an RM sign ambiguity introduced by path length differences in the system’s electronics. We apply the pipeline to a bright burst previously reported (FRB 20191219F), detecting an RM of +6.074 ± 0.006 ± 0.050 rad m
−2
with a significant linear polarized fraction (≳0.87) and strong evidence for a non-negligible circularly polarized component. Finally, we introduce an RM search method that employs a phase-coherent de-rotation algorithm to correct for intra-channel depolarization in data that retain electric field phase information and successfully apply it to an unpublished FRB, FRB 20200917A, measuring an RM of −1294.47 ± 0.10 ± 0.05 rad m
−2
(the second largest unambiguous RM detection from any FRB source observed to date).
Abstract
The object FRB 20180916B is a well-studied repeating fast radio burst source. Its proximity (∼150 Mpc), along with detailed studies of the bursts, has revealed many clues about its nature, ...including a 16.3 day periodicity in its activity. Here we report on the detection of 18 bursts using LOFAR at 110–188 MHz, by far the lowest-frequency detections of any FRB to date. Some bursts are seen down to the lowest observed frequency of 110 MHz, suggesting that their spectra extend even lower. These observations provide an order-of-magnitude stronger constraint on the optical depth due to free–free absorption in the source’s local environment. The absence of circular polarization and nearly flat polarization angle curves are consistent with burst properties seen at 300–1700 MHz. Compared with higher frequencies, the larger burst widths (∼40–160 ms at 150 MHz) and lower linear polarization fractions are likely due to scattering. We find ∼2–3 rad m
−2
variations in the Faraday rotation measure that may be correlated with the activity cycle of the source. We compare the LOFAR burst arrival times to those of 38 previously published and 22 newly detected bursts from the uGMRT (200–450 MHz) and CHIME/FRB (400–800 MHz). Simultaneous observations show five CHIME/FRB bursts when no emission is detected by LOFAR. We find that the burst activity is systematically delayed toward lower frequencies by about 3 days from 600 to 150 MHz. We discuss these results in the context of a model in which FRB 20180916B is an interacting binary system featuring a neutron star and high-mass stellar companion.
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