Book Reviews Peruško, Uroš; Rosenzweig, Dean; Budin, Andrea ...
Journal of computing and information technology,
09/1996, Letnik:
4, Številka:
3
Book Review
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This is the anniversary edition of Brooks's authoritative book The Mythical Man-Month whose first edition appeared already in 1975. In it the author elaborates on the methodology of software ...development and tribulations of software project management based on his vast personal experience in this domain. In fact, the undertitle of the book - Essays on Software Engineering - is its best description, Brooks being concerned primarily with productivity in developing large software systems. The book is written very clearly and shows deep insight into this problem, using an informal style to present individual issues and related conclusions, thus making reading it a pure delight.
Book Reviews Sruk, Vlado; Vuković, Dragutin; Glavinić, Vlado ...
Journal of computing and information technology,
03/1996, Letnik:
4, Številka:
1
Book Review
Recenzirano
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PC System Architecture Series is a crisply written and comprehensive set of guides to the most important PC hardware standards. The series addresses a readership that has had exposure to PCs in a ...technical capacity but otherwise assumes a moderate technical knowledge only. According to the preface of the series, the material published is intended for those professionally involved in hardware and software design as well as for PC support personnel.
Book Reviews Šribar, Julijan; Matić, Ninoslav; Budin Posavec, Andrea
Journal of computing and information technology,
03/1997, Letnik:
5, Številka:
1
Book Review
Recenzirano
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Most professional programmers are well acquainted with the problem of code reusability. Libraries with standard functions are available for all programming languages, but writing libraries of one's ...own, in such a way that they could be used later in many different projects, requires the programmer's thorough approach. This particularly holds for C++ programming language.
Multilingualism is a cultural cornerstone of Europe and firmly anchored in the European treaties including full language equality. However, language barriers impacting business, cross-lingual and ...cross-cultural communication are still omnipresent. Language Technologies (LTs) are a powerful means to break down these barriers. While the last decade has seen various initiatives that created a multitude of approaches and technologies tailored to Europe's specific needs, there is still an immense level of fragmentation. At the same time, AI has become an increasingly important concept in the European Information and Communication Technology area. For a few years now, AI, including many opportunities, synergies but also misconceptions, has been overshadowing every other topic. We present an overview of the European LT landscape, describing funding programmes, activities, actions and challenges in the different countries with regard to LT, including the current state of play in industry and the LT market. We present a brief overview of the main LT-related activities on the EU level in the last ten years and develop strategic guidance with regard to four key dimensions.
Spread of antibiotic resistance among bacteria responsible for nosocomial and community-acquired infections urges for novel therapeutic or prophylactic targets and for innovative pathogen-specific ...antibacterial compounds. Major challenges are posed by opportunistic pathogens belonging to the low GC% Gram-positive bacteria. Among those, Enterococcus faecalis is a leading cause of hospital-acquired infections associated with life-threatening issues and increased hospital costs. To better understand the molecular properties of enterococci that may be required for virulence, and that may explain the emergence of these bacteria in nosocomial infections, we performed the first large-scale functional analysis of E. faecalis V583, the first vancomycin-resistant isolate from a human bloodstream infection. E. faecalis V583 is within the high-risk clonal complex 2 group, which comprises mostly isolates derived from hospital infections worldwide. We conducted broad-range screenings of candidate genes likely involved in host adaptation (e. g., colonization and/or virulence). For this purpose, a library was constructed of targeted insertion mutations in 177 genes encoding putative surface or stress-response factors. Individual mutants were subsequently tested for their i) resistance to oxidative stress, ii) antibiotic resistance, iii) resistance to opsonophagocytosis, iv) adherence to the human colon carcinoma Caco-2 epithelial cells and v) virulence in a surrogate insect model. Our results identified a number of factors that are involved in the interaction between enterococci and their host environments. Their predicted functions highlight the importance of cell envelope glycopolymers in E. faecalis host adaptation. This study provides a valuable genetic database for understanding the steps leading E. faecalis to opportunistic virulence.
Spread of antibiotic resistance among bacteria responsible for nosocomial and community-acquired infections urges for novel therapeutic or prophylactic targets and for innovative pathogen-specific ...antibacterial compounds. Major challenges are posed by opportunistic pathogens belonging to the low GC% Gram-positive bacteria. Among those, Enterococcus faecalis is a leading cause of hospital-acquired infections associated with life-threatening issues and increased hospital costs. To better understand the molecular properties of enterococci that may be required for virulence, and that may explain the emergence of these bacteria in nosocomial infections, we performed the first large-scale functional analysis of E. faecalis V583, the first vancomycin-resistant isolate from a human bloodstream infection. E. faecalis V583 is within the high-risk clonal complex 2 group, which comprises mostly isolates derived from hospital infections worldwide. We conducted broad-range screenings of candidate genes likely involved in host adaptation (e. g., colonization and/or virulence). For this purpose, a library was constructed of targeted insertion mutations in 177 genes encoding putative surface or stress-response factors. Individual mutants were subsequently tested for their i) resistance to oxidative stress, ii) antibiotic resistance, iii) resistance to opsonophagocytosis, iv) adherence to the human colon carcinoma Caco-2 epithelial cells and v) virulence in a surrogate insect model. Our results identified a number of factors that are involved in the interaction between enterococci and their host environments. Their predicted functions highlight the importance of cell envelope glycopolymers in E. faecalis host adaptation. This study provides a valuable genetic database for understanding the steps leading E. faecalis to opportunistic virulence.
