Physics with e+e− linear colliders Accomando, E.; Andreazza, A.; Ballestrero, A. ...
Physics reports,
06/1998, Letnik:
299, Številka:
1
Journal Article
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The physics potential of
e
+
e
− linear colliders is summarized in this report. These machines are planned to operate in the first phase at a center-of-mass energy of 500
GeV, before being scaled up ...to about 1
TeV. In the second phase of the operation, a final energy of about 2
TeV is expected. The machines will allow us to perform precision tests of the heavy particles in the Standard Model, the top quark and the electroweak bosons. They are ideal facilities for exploring the properties of Higgs particles, in particular in the intermediate mass range. New vector bosons and novel matter particles in extended gauge theories can be searched for and studied thoroughly. The machines provide unique opportunities for the discovery of particles in supersymmetric extensions of the Standard Model, the spectrum of Higgs particles, the supersymmetric partners of the electroweak gauge and Higgs bosons, and of the matter particles. High precision analyses of their properties and interactions will allow for extrapolations to energy scales close to the Planck scale where gravity becomes significant. In alternative scenarios, i.e. compositeness models, novel matter particles and interactions can be discovered and investigated in the energy range above the existing colliders up to the TeV scale. Whatever scenario is realized in Nature, the discovery potential of
e
+
e
− linear colliders and the high precision with which the properties of particles and their interactions can be analyzed, define an exciting physics program complementary to hadron machines.
Amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) constitutes a devastating disease spectrum characterized by 43-kDa TAR DNA-binding protein (TDP-43) pathology. Understanding how TDP-43 ...contributes to neurodegeneration will help direct therapeutic efforts. Here we have created a TDP-43 knock-in mouse with a human-equivalent mutation in the endogenous mouse Tardbp gene. TDP-43
mice demonstrate cognitive dysfunction and a paucity of parvalbumin interneurons. Critically, TDP-43 autoregulation is perturbed, leading to a gain of TDP-43 function and altered splicing of Mapt, another pivotal dementia-associated gene. Furthermore, a new approach to stratify transcriptomic data by phenotype in differentially affected mutant mice revealed 471 changes linked with improved behavior. These changes included downregulation of two known modifiers of neurodegeneration, Atxn2 and Arid4a, and upregulation of myelination and translation genes. With one base change in murine Tardbp, this study identifies TDP-43 misregulation as a pathogenic mechanism that may underpin ALS-FTD and exploits phenotypic heterogeneity to yield candidate suppressors of neurodegenerative disease.
Production of exclusive dijets in diffractive deep inelastic Formula omitted scattering has been measured with the ZEUS detector at HERA using an integrated luminosity of 372 pb Formula omitted. The ...measurement was performed for Formula omitted-p centre-of-mass energies in the range Formula omitted and for photon virtualities Formula omitted. Energy flows around the jet axis are presented. The cross section is presented as a function of Formula omitted and Formula omitted, where Formula omitted, x is the Bjorken variable and Formula omitted is the proton fractional longitudinal momentum loss. The angle Formula omitted is defined by the Formula omitted-dijet plane and the Formula omitted- Formula omitted plane in the rest frame of the diffractive final state. The Formula omitted cross section is measured in bins of Formula omitted. The results are compared to predictions from models based on different assumptions about the nature of the diffractive exchange.
Although diverse measurements have indicated H+, OH−, or H2O species in the lunar polar regions, pinpointing its location, form, and abundance in specific reservoirs has proven elusive. Here we ...report on the first orbital radar measurements of Shackleton crater near the lunar south pole. Mini‐RF observations indicate a patchy, heterogeneous enhancement in CPR (circular polarization ratio) on the crater walls whose strength decreases with depth toward the crater floor, a result that is most consistent with a roughness effect due to less mature regolith present on the crater wall slopes. However, the results do not rule out a modest ice contribution, and an upper limit of ∼5–10 wt% H2O ice (up to 30 vol.%) present in the uppermost meter of regolith is also consistent with the observations.
Key Points
An upper bound on the amount of ice in this crater is ~5 wt%
Radar data has been obtained for all of Shackleton, a first
No evidence for thick, meters‐thick ice is found
Growing evidence supports a major contribution of cortical serotonin (5-hydroxytryptamine, 5-HT) to the modulation of cognitive flexibility and the cognitive inflexibility evident in neuropsychiatric ...disorders. The precise role of 5-HT and the influence of 5-HT gene variation in mediating this process is not fully understood. Using a touch screen–based operant system, we assessed reversal of a pairwise visual discrimination as an assay for cognitive flexibility. Effects of constitutive genetic or pharmacological inactivation of the 5-HT transporter (5-HTT) on reversal were examined by testing 5-HTT null mice and chronic fluoxetine-treated C57BL/6J mice, respectively. Effects of constitutive genetic loss or acute pharmacological depletion of 5-HT were assessed by testing Pet-1 null mice and para-chlorophenylalanine (PCPA)–treated C57BL/6J mice, respectively. Fluoxetine-treated C57BL/6J mice made fewer errors than controls during the early phase of reversal when perseverative behavior is relatively high. 5-HTT null mice made fewer errors than controls in completing the reversal task. However, reversal in Pet-1 null and PCPA-treated C57BL/6J mice was not different from controls. These data further support an important role for 5-HT in modulating reversal learning and provide novel evidence that inactivating the 5-HTT improves this process. These findings could have important implications for understanding and treating cognitive inflexibility in neuropsychiatric disease.
The Lunar Orbiter Laser Altimeter (LOLA) measures the backscattered energy of the returning altimetric laser pulse at its wavelength of 1064 nm, and these data are used to map the reflectivity of the ...Moon at zero‐phase angle with a photometrically uniform data set. Global maps have been produced at 4 pixels per degree (about 8 km at the equator) and 2 km resolution within 20° latitude of each pole. The zero‐phase geometry is insensitive to lunar topography, so these data enable characterization of subtle variations in lunar albedo, even at high latitudes where such measurements are not possible with the Sun as the illumination source. The geometric albedo of the Moon at 1064 nm was estimated from these data with absolute calibration derived from the Kaguya Multiband Imager and extrapolated to visual wavelengths. The LOLA estimates are within 2σ of historical measurements of geometric albedo. No consistent latitude‐dependent variations in reflectance are observed, suggesting that solar wind does not dominate space weathering processes that modify lunar reflectance. The average normal albedo of the Moon is found to be much higher than that of Mercury consistent with prior measurements, but the normal albedo of the lunar maria is similar to that of Mercury suggesting a similar abundance of space weathering products. Regions within permanent shadow in the polar regions are found to be more reflective than polar surfaces that are sometimes illuminated. Limiting analysis to data with slopes less than 10° eliminates variations in reflectance due to mass wasting and shows a similar increased reflectivity within permanent polar shadow. Steep slopes within permanent shadow are also more reflective than similar slopes that experience at least some illumination. Water frost and a reduction in effectiveness of space weathering are offered as possible explanations for the increased reflectivity of permanent shadow; porosity is largely ruled out as the sole explanation. The south polar crater Shackleton is found to be among the most reflective craters in its size range globally but is not the most reflective, so mass wasting cannot be ruled out as a cause for the crater's anomalous reflectance. Models of the abundance of ice needed to account for the reflectance anomaly range from 3 to 14% by weight or area depending on assumptions regarding the effects of porosity on reflectance and whether ice is present as patches or is well mixed in the regolith. If differences in nanophase iron abundances are responsible for the anomaly, the permanently shadowed regions have between 50 and 80% the abundance of nanophase iron in mature lunar soil.
Key Points
Global lunar map of zero‐phase reflectance derived from LOLA 1064 nm dataPermanently shadowed regions in the poles are anomalously brightBright PSRs could be due to water frost and/or less effective space weathering
DNA vaccination using plasmid encoding the hemagglutinin (HA) gene of influenza A/PR/8/34 virus to induce long-lasting protective immunity against respiratory infection was evaluated in this study. ...Using liposomes as carriers, the efficacy of DNA vaccines was determined using a lethal influenza infection model in mice. Mice immunized intranasally or intramuscularly with liposome-encapsulated pCI plasmid encoding HA (pCI-HA10) were completely protected against an intranasal 5 LD
50 influenza virus challenge. Mice immunized with liposome-encapsulated pCI-HA10, but not naked pCI-HA10, by intranasal administration were found to produce high titers of serum IgA. These results suggest DNA vaccines encapsulated in liposomes are efficacious in inducing complete protective immunity against respiratory influenza virus infection.
Several mouse models of Alzheimer's disease (AD) with abundant β-amyloid and/or aberrantly phosphorylated tau develop memory impairments. However, multiple non-mnemonic cognitive domains such as ...attention and executive control are also compromised early in AD individuals. Currently, it is unclear whether mutations in the β-amyloid precursor protein (APP) and tau are sufficient to cause similar, AD-like attention deficits in mouse models of the disease. To address this question, we tested 3xTgAD mice (which express APPswe, PS1M146V, and tauP301L mutations) and wild-type control mice on a newly developed touchscreen-based 5-choice serial reaction time test of attention and response control. The 3xTgAD mice attended less accurately to short, spatially unpredictable stimuli when the attentional demand of the task was high, and also showed a general tendency to make more perseverative responses than wild-type mice. The attentional impairment of 3xTgAD mice was comparable to that of AD patients in two aspects: first, although 3xTgAD mice initially responded as accurately as wild-type mice, they subsequently failed to sustain their attention over the duration of the task; second, the ability to sustain attention was enhanced by the cholinesterase inhibitor donepezil (Aricept). These findings demonstrate that familial AD mutations not only affect memory, but also cause significant impairments in attention, a cognitive domain supported by the prefrontal cortex and its afferents. Because attention deficits are likely to affect memory encoding and other cognitive abilities, our findings have important consequences for the assessment of disease mechanisms and therapeutics in animal models of AD.
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