Skin is a complex and dynamic organ that provides a protective interface between the external environment and the body; changes in skin appearance are often the first visible signs of aging. It is ...well established that nutrients and other bioactive substances have important roles in the structure and functions of human skin; however, the effects of dietary supplementation of such bioactives are much less investigated. The objective of this randomised, double-blind placebo-controlled study was to investigate the effects of liquid food supplement, characterised by a combination of water-soluble coenzyme Q10 (Q10Vital®) and collagen, on dermal density and other skin parameters in comparison to placebo. The trial was performed on 34 healthy women aged 40–65 that received either the test product (n = 17) or the placebo (n = 17) for twelve weeks. Measurements and assessments of skin parameters were performed at baseline and after 12 weeks of intervention. We observed improved dermis density, reduced periorbital wrinkle area and the total wrinkle score, and improved skin smoothness. On the other hand, changes in skin hydration, dermis thickness, transepidermal water loss (TEWL) and viscoelasticity were not significant.
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•12-week supplementation with collagen improved skin density, texture and wrinkles.•Addition of MSM proved beneficial for improvement in skin texture and thickness.•5g of collagen ...with MSM was sufficient to improve the majority of the parameters.•Interventions did not result in significant effects on TEWL and viscoelasticity.
Dietary supplementation with collagen has been gaining popularity as an anti-ageing remedy. The aim of this randomised, double-blind placebo-controlled four-way study was to investigate and compare the effects of 12-week daily dietary supplementation with products containing 10 g hydrolysed fish collagen (HC) or a combination of 5 g or 10 g HC with 1.5 g methylsulphonylmethane (MSM) on dermis density in healthy human subjects. The secondary objectives were to investigate the effects on a variety of other skin parameters. The study results showed improved dermis density, skin texture and reduced wrinkles for all the active products. However, products containing MSM were superior in the improvement of skin thickness and roughness, and a higher dose of HC combined with MSM was crucial for improvement in hydration. On the other hand, no significant effects of the supplementation on viscoelasticity and transepidermal water loss were determined with any of the products.
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•Lutein supplementation (3 months) increased minimal erythema dose.•Skin photoprotective activity increased for 22% and skin photoprotective potential improved.•Dietary lutein could ...contribute to skin defense against UVR-mediated damage.•We did not observe skin regeneration effects.
Various studies showed promising photoprotective and anti-aging effects of lutein, but it was mostly investigated in combination with other antioxidants, and some study results are contradictory. The aim of this randomized, double-blind placebo-controlled intervention was to investigate the effects of dietary lutein supplementation on minimal erythema dose (MED) as a measure of skin’s photoprotective potential, and other skin parameters. Thirty healthy women received supplementation of lutein (20 mg/day; liquid formulation) or placebo for 12 weeks. In the test group, MED was significantly increased, indicating greater individual’s resistance to the production of erythema following UV radiation. The overall treatment effect was 0.114 J/cm2 corresponding to a relative increase of photoprotective activity of 22%. On the other hand, we were unable to confirm supportive effects for skin regeneration. Study findings show that dietary supplementation with lutein improved skin photoprotective potential and could contribute to skin defense against UVR-mediated skin damage.
Most data related to cutaneous melanoma survivors' health behaviour comes from epidemiological studies and is predominantly concerned with safe-sun behaviour and self-examination. Data regarding ...other changes of health behaviour are scarce and so are qualitative studies in this realm. The aim of our research is to acquire insight into the experiences of patients with cutaneous melanoma in Slovenia. How did they react to the diagnosis, which changes did they introduce in their health behaviour and how do they assess the role of family doctors?
Using the qualitative approach of collective case reports, a demographically diverse group of patients with different forms and stages of cutaneous melanoma was selected. Semi-structured interviews conducted by a psychologist were recorded and transcribed verbatim. For data processing, the approach of Qualitative Content Analysis was applied.
We integrated interviewees' experiences after the diagnosis of cutaneous melanoma in several subcategories: either they did not introduce any changes or they mentioned changing their habits when exposed to the sun and performing skin self-examination; they also emphasized their ways of dealing with stress and raising awareness about melanoma among family members and friends. The role of family doctors in the prevention and care appears unclear; even contradictory.
We obtained insight into the experiences of Slovenian patients with cutaneous melanoma. The interviewees prioritised safe behaviour in the sun, strengthening of psychological stability and raising awareness about melanoma. Findings will be used in the creation of a structured questionnaire for national epidemiological survey.
Aim of this study was to investigate changes in health behavior of melanoma survivors with emphasis on safe sun behavior (SSB) and skin self-examination (SSE). We also identified factors with ...significant impact on SSE improvement. We performed a cross-sectional (epidemiological) survey based on a structured questionnaire. 150 patients from three medical institutions were invited and 144 patients responded. Statistical analysis was performed with SPSS version 23.0, with the level of significance set to 0.05. After being diagnosed with cutaneous melanoma, patients significantly improved preventive health behavior: 68.1% showed improvement in SSE, and 91.5% of patients improved SSB. There was statistically significant (P<0.001) improvement in the frequency of skin examination, examination of poorly visible areas (between the toes, genitals), and obtaining help in examination. Use of melanoma images remained scarce. Results for SSB were even better, and statistically significant improvement was recorded in all areas: using higher UV protection filters, wearing sunglasses, headgear, long sleeves, and trousers, and especially in staying in deep shade during hours of heavy UV radiation. The only factor with a positive influence on expected improvement in SSE was female gender. On the other hand, there were two factors that had a negative impact on SSE: patients with melanoma stage 1 and patients who had already self-examined themselves before their melanoma diagnosis. Preventive health behavior improved significantly after diagnosis of cutaneous melanoma. Patients markedly improved SSB and substantially enhanced SSE. We believe that it is reasonable to improve SSE further, encouraging patients by increasing their feeling of self-efficacy.
Collagen dietary supplements are becoming increasingly popular as a means to reduce signs of skin ageing. The objective of this three-way, randomised, placebo-controlled, double-blind study was to ...examine and contrast the effects of dietary supplementation with a daily dose of 5 g hydrolysed collagen with 80 mg of vitamin C (CP product) and their combination with 30 mg of hyaluronic acid (CPHA product) over 16 weeks. Validated methods were utilised for the objective evaluation of skin parameters. In total, 87 subjects (women, 40–65 years) completed the entire trial, distributed across the groups as follows: placebo group (n = 29), CPHA group (n = 28), and CP group (n = 30). The results showed beneficial effects of both test products, with notable enhancements in dermis density, skin texture, and a reduction in the severity of wrinkles. In contrast, the administration of either of the products did not yield any significant impacts on skin elasticity or hydration. Observation of the investigated skin parameters did not show superior effects of the addition of hyaluronic acid (HA) to collagen. Therefore, the ability of supplementation with HA to improve the effects on investigated skin parameters beyond the supplementation of collagen alone cannot be confirmed.
Aim: To investigate the efficacy and tolerability of a cream (Rilastil Xerolact PB) containing a mixture of prebiotics and postbiotics, and to validate the PRURISCORE itch scale in the management of ...atopic dermatitis.
Methods: The study is based on 396 subjects of both sexes in three age groups (i.e., infants, children, adults) suffering from mild/moderate Atopic Dermatitis, recruited from 8 European countries and followed for 3 months.
Results: The product demonstrated good efficacy combined with good/very good tolerability in all age groups. In particular, SCORAD, PRURISCORE and IGA scores decreased significantly over the course of the study. The PRURISCORE was preferred to VAS by the vast majority of patients.
Conclusion: Even though the role of prebiotics and postbiotics was not formally demonstrated since these substances were part of a complex formulation, it can be reasonably stated that prebiotics and postbiotics have safety and standardization features that probiotics do not have. In addition they are authorized by regulatory authorities, whereas topical probiotics are not.
Skin is a complex and dynamic organ that provides a protective interface between theexternal environment and the body; changes in skin appearance are often the first visible signs ofaging. It is well ...established that nutrients and other bioactive substances have important roles in thestructure and functions of human skin; however, the effects of dietary supplementation of suchbioactives are much less investigated. The objective of this randomised, double-blind placebocontrolledstudy was to investigate the effects of liquid food supplement, characterised by acombination of water-soluble coenzyme Q10 (Q10Vital®) and collagen, on dermal density and otherskin parameters in comparison to placebo. The trial was performed on 34 healthy women aged 40-65 that received either the test product (
= 17) or the placebo (
= 17) for twelve weeks.Measurements and assessments of skin parameters were performed at baseline and after 12 weeksof intervention. We observed improved dermis density, reduced periorbital wrinkle area and thetotal wrinkle score, and improved skin smoothness was observed. On the other hand, changes inskin hydration, dermis thickness, transepidermal water loss (TEWL) and viscoelasticity were notsignificant.
Physiological acne is a milder form of clinical acne and is very frequent in adult women (18 years of age and older). Acne therapy is usually unnecessary in such cases, and so appropriate cosmetic ...treatments are sought.
To determine the effectiveness of a topical cosmetic hydrating skincare treatment for adult acne-prone skin (Normaderm, Vichy, France) against the clinical signs of physiological acne: few inflammatory and retentional lesions, uneven (grainy) skin relief, dilated pores, and occasional and/or local hyperseborrhea.
Within the study, the tested product's keratolytic, antimicrobial, and antiseborrheic properties, and its overall ability to improve the clinical signs of physiological acne present in adult subjects were evaluated through objective and clinical evaluation methods by the investigators and through self-evaluation questionnaires by the subjects themselves. The study group was composed of 50 adult women between 18 and 35 years of age with combination or oily acne-prone skin, who were chosen according to previously defined inclusion criteria. They applied the product tested twice daily on thoroughly cleansed skin for a period of 2 months. The results were evaluated after 30 (±2) and 60 (±2) days.
The number of inflammatory and retentional lesions on the forehead, cheeks, and chin decreased after 60 days of use (an average of 30.7% and 70.7%, respectively). The level of sebum secretion on the forehead decreased by 33.4% and the level of skin scaling decreased by 38.5% after 60 days of use. The moisture content in the horny layer on the forehead, cheeks, and chin increased by an average 39.7%. The decrease in pore size and content after 60 days of use was very noticeable. The subjects evaluated all the studied characteristics of the product tested very positively, with results already showing after 30 days of use.
The results of the study confirm that the product tested is suitable for the cosmetic care of adult acne-prone skin, either as an independent cosmetic hydrating skincare treatment, as a complementary cosmetic part of acne therapy, or as a subsequent cosmetic regimen to sustain the results of the acne therapy for a longer period of time.
Aim of this study was toinvestigate changes in health behavior of melanoma survivors with emphasis on safe sun behavior (SSB) and skin self-examination (SSE). We also identified factors with ...significant impact on SSE improvement. We performed a cross-sectional (epidemiological) survey based on a structured questionnaire. 150 patients from three medical institutions were invited and 144 patients responded. Statistical analysis was performed with SPSS version 23.0, with the level of significance set to 0.05. After being diagnosed with cutaneous melanoma, patients significantly improved preventive health behavior: 68.1% showed improvement in SSE, and 91.5% of patients improved SSB. There was statistically significant ( P <0.001) improvement in the frequency of skin examination, examination of poorly visible areas (between the toes, genitals), and obtaining help in examination. Use of melanoma images remained scarce. Results for SSB were even better, and statistically significant improvement was recorded in all areas: using higher UV protection filters, wearing sunglasses, headgear, long sleeves, and trousers, and especially in staying in deep shade during hours of heavy UV radiation. The only factor with a positive influence on expected improvement in SSE was female gender. On the other hand, there were two factors that had a negative impact on SSE: patients with melanoma stage 1 and patients who had already self-examined themselves before their melanoma diagnosis. Preventive health behavior improved significantly after diagnosis of cutaneous melanoma. Patients markedly improved SSB and substantially enhanced SSE. We believe that it is reasonable to improve SSE further, encouraging patients by increasing their feeling of self-efficacy.
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