Light‐Emitting Electrochemical Cells
In article number 2302483, research labs of Rubén D. Costa and Ken Albrecht, have joined efforts to develop light‐emitting electrochemical cells combining ...thermally activated delayed fluorescent dendrimer emitters, biogenic electrolytes, and graphene‐based electrodes. These devices exhibit exceptional stability, comparable to other state‐of‐the‐art materials, while providing advantages, such as low‐cost up‐scalable synthesis, easy tunability using simple substituents, and high tolerance to electrodes and electrolytes.
Even with high-dose post-transplant cyclophosphamide (PT-Cy) which was initially introduced for graft-versus-host disease (GvHD) prevention in the setting of HLA-haploidentical transplantation, both ...acute and chronic GvHDs remain a major clinical challenge. Despite improvements in the understanding of the pathogenesis of both acute and chronic GvHDs, reliable biomarkers that predict their onset have yet to be identified. We recently studied the potential correlation between extracellular vesicles (EVs) and the onset of acute (a)GvHD in transplant recipients from related and unrelated donors. In the present study, we further investigated the role of the expression profile of membrane proteins and their microRNA (miRNA) cargo (miRNA100, miRNA155, and miRNA194) in predicting the onset of aGvHD in haploidentical transplant recipients with PT-Cy. Thirty-two consecutive patients were included. We evaluated the expression profile of EVs, by flow cytometry, and their miRNA cargo, by real-time PCR, at baseline, prior, and at different time points following transplant. Using logistic regression and Cox proportional hazard models, a significant association between expression profiles of antigens such as CD146, CD31, CD140a, CD120a, CD26, CD144, and CD30 on EVs, and their miRNA cargo with the onset of aGvHD was observed. Moreover, we also investigated a potential correlation between EV expression profile and cargo with plasma biomarkers (e.g., ST2, sTNFR1, and REG3a) that had been associated with aGVHD previously. This analysis showed that the combination of CD146, sTNFR1, and miR100 or miR194 strongly correlated with the onset of aGvHD (AUROC >0.975). A large prospective multicenter study is currently in progress to validate our findings.
Abstract
We present the results of our search near the end of the Reionization Epoch for faint galaxies. This has been done using very deep OSIRIS images obtained at the Gran Telescopio Canarias ...(GTC). Our observations focus around two close, massive Lyman α emitters (LAEs) at redshift 6.5, discovered in the SXDS field within a large-scale overdense region. The total GTC observing time in three medium band filters (F883w35, F913w25 and F941w33) is over 34 h covering 7.0 × 8.5 arcmin2 (or ∼30 000 Mpc3 at z = 6.5). In addition to the two spectroscopically confirmed LAEs in the field, we have identified 45 other LAE candidates. The preliminary luminosity function derived from our observations, assuming a spectroscopic confirmation success rate of 2/3 as in previous surveys, suggests this area is about 2 times denser than the general field galaxy population at z = 6.5. If confirmed spectroscopically, our results will imply the discovery of one of the earliest protoclusters in the Universe, which will evolve to resemble the most massive galaxy clusters today.
Organic material deposition by gravure printing is a promising pathway for the realization of large area flexible electronic devices. Nevertheless, in order to achieve high performance it is required ...to improve the electronic ink printability, operating on the fluid dynamic mechanisms involved during the process. In this work, this issue has been faced working on ink characteristics for a conductive and a dielectric material. The suitable ink features have been defined studying the influence on the printability of the different forces that act in the fluid during the printing process, using an experimental approach. Properly defined ink formulations have been printed, considering different shapes and dimensions of the cells on the gravure cliché to fit the ink features. The printing outcomes have been compared and analysed through the evaluation of several significant fluid dynamic parameters and the rheological characterization of the materials. Finally, exploiting the results of this study, high performance fully printed organic thin film transistors have been realized.
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•Deep understanding of the fluid dynamic behaviour of organic gravure inks.•Ink printability improvement through analyses of ink fluid dynamic parameters and rheology.•Organic ink printing outcome evaluation.•Definition of a parameter range to obtain acceptable gravure printing outcomes.•Realization of high performance fully printed organic thin film transistors.
Abstract
Funding Acknowledgements
Type of funding sources: None.
Background
Structural and functional remodeling of left and right atrium (LA-RA) are predictors of the risk of hospitalization and ...mortality. These are chronic and complex processes, dependent on an adaptive response implemented by the atrial myocytes against stressors of an electrical, mechanical and metabolic nature. Atrial fibrillation (AF) is the most common condition associated with remodeling of both atria, of which it can be cause and effect at the same time: atrial enlargement, interstitial fibrosis and myocardial distension. Often the first manifestation of AF is cryptogenic stroke (CS) which is associated with a high rate of recurrence and adverse long-term follow-up outcomes, mainly due to its unknown etiology often leading to secondary prevention ineffective. Asymptomatic (AF) may play an important pathophysiological role to detect CS. Evidence has demonstrated the efficacy of AF ablation in restoring the structure of the LA and, consequently, in favoring the maintenance of sinus rhythm. However, little is known regarding the evaluation of RA remodeling and its variation over time in patients with FA.
Aim of the study
Evaluate the relationship between echocardiographic parameters of LA and RA function, and the occurrence of AF revealed by continuous ECG monitoring through insertable cardiac monitors (ICM) implant in a cohort of patients with CS
Methods
Single-center retrospective study. A total of 204 patients who suffered from cryptogenic stroke underwent ICM between May 2013 and July 2022. All detected AF episodes lasting more than 30 seconds were considered, according to Guidelines. All patients underwent to Transthoracic Echocardiography (TTE) to study on LA and RA function, including both standard and longitudinal strain-derived parameters. Transesophageal Echocardiography (TEE) was also performed to exclude embolic sources.
Results
During a median follow-up period of 15.3 months (interquartile range, 7.4 / 23.5), continuous ECG monitoring revealed AF in 96 patients (47.0%). Many echocardiographic parameters, such as LA maximum and minimal volume were significantly associated with the occurrence of AF, suggesting the worst atrial function in the AF group. Furthermore, multivariable regression analysis revealed that peak atrial contraction strain of both atria were independently associated with AF (p < 0.001,respectively).
Conclusion
In patients with cryptogenic CS, LA and RA strain analysis are strong and independent predictors of the occurrence of AF despite clinical and morpho-functional echocardiographic parameters.
The SwissFEL X-ray Free Electron Laser (XFEL) facility started construction at the Paul Scherrer Institute (Villigen, Switzerland) in 2013 and will be ready to accept its first users in 2018 on the ...Aramis hard X-ray branch. In the following sections we will summarize the various aspects of the project, including the design of the soft and hard X-ray branches of the accelerator, the results of SwissFEL performance simulations, details of the photon beamlines and experimental stations, and our first commissioning results.
The clinical manifestation of COVID‐19 can vary from an asymptomatic course to ARDS requiring invasive mechanical ventilation and extracorporeal membrane oxygenation. A kidney transplanted patient ...infected with SARS CoV‐2 infection showed a mild disease despite immune suppression. It is possible that Immunosuppression can “be protective” as the cytokine storm is an important factor in the disease story. Despite the good outcome reported in the present case report, is remains of vital importance the solid organ transplant patients use precautions in order to avoid the infection.
A kidney‐transplanted patient infected with SARS‐CoV‐2 shows a mild disease despite immune suppression, leading the authors to think it may be possible that immunosuppression can be protective, as the cytokine storm is an important factor in the disease story.
Abstract
Objective
Redo cardiac surgery through median sternotomy still represents a challenging procedure due to the high risk of graft injuries, the presence of dense adhesions and complex valve ...exposure. The use of a minithoracotomy approach may reduce the surgical complexity. We report our experience performing redo mitral valve surgery through a right–sided mini–thoracotomy.
Methods
From march 2010 to May 2022, 58 patients (Median age 68 years (IQR 56–76) and 41.4% females) underwent redo mitral valve surgery through right anterior thoracotomy at our institution. Median EuroSCORE II was 3.83 (IQR 2.54–7.28).
Results
The median time from the original operation to redo surgery was 6.1 (1.0–10.3) years. First surgery was mitral repair in 60% of patients, mitral valve replacement in 15%, Coronary Artery Bypass Grafting in 12% and Aortic valve Replacement in nearly 9% of our population. Four patients (6.9%) were affected by active endocarditis at the time of surgery. Median cardiopulmonary bypass and cross–clamp times were 120 (IQR 80–148) minutes and 81 (IQR 59.5–114) minutes, respectively. No conversion to full sternotomy was necessary. Twenty–eight patients (48.3%) required transfusions with packed blood cells. Post–operative atrial fibrillation was observed in 6 patients (10.3%) and 7 patient (12.1%) required Pace–maker implantation due to third degree AV block. Moreover, we observed 1 rethoracotomy for bleeding (1.7%). One patient (1.7%) required re–intubation, dialysis and Extracorporeal Life Support, for a septic shock that finally caused exitus. Median ventilation time was 7 hours (IQR 4–13). Median ICU and in–hospital length of stay were 2 (IQR 2–3) days and 10 (IQR 8–15) days respectively. In–hospital and 30–days mortality was 1.7%.
Conclusions
In our experience, a minimally invasive approach through right thoracotomy for redo mitral valve procedures is safe and feasible, with acceptable CPB and Cross–clamp times and good in–hospital outcomes. Therefore, it can be an attractive option for patients with previous cardiac surgery, above all for patients with patent grafts. Further studies are needed with a bigger population and a comparison to full sternotomy results.
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