In this paper we propose a new strategy, based on anomaly detection methods, to search for new physics phenomena at colliders independently of the details of such new events. For this purpose, ...machine learning techniques are trained using Standard Model events, with the corresponding outputs being sensitive to physics beyond it. We explore three novel AD methods in HEP: Isolation Forest, Histogram-Based Outlier Detection, and Deep Support Vector Data Description; alongside the most customary Autoencoder. In order to evaluate the sensitivity of the proposed approach, predictions from specific new physics models are considered and compared to those achieved when using fully supervised deep neural networks. A comparison between shallow and deep anomaly detection techniques is also presented. Our results demonstrate the potential of semi-supervised anomaly detection techniques to extensively explore the present and future hadron colliders’ data.
In this paper, we expand on the previously proposed concept of energy Mover’s distance. The resulting observables are shown to provide a way of identifying rare processes in proton–proton collider ...experiments. It is shown that different processes are grouped together differently and that this can contribute to the improvement of experimental analyses. The
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production at the Large Hadron Collider is used as a benchmark to illustrate the applicability of the method. Furthermore, we study the use of these observables as new features which can be used in the training of deep neural networks.
The 30 Doradus star-forming region in the Large Magellanic Cloud is a nearby analog of large star-formation events in the distant universe. We determined the recent formation history and the initial ...mass function (IMF) of massive stars in 30 Doradus on the basis of spectroscopic observations of 247 stars more massive than 15 solar masses (Formula: see text). The main episode of massive star formation began about 8 million years (My) ago, and the star-formation rate seems to have declined in the last 1 My. The IMF is densely sampled up to 200 Formula: see text and contains 32 ± 12% more stars above 30 Formula: see text than predicted by a standard Salpeter IMF. In the mass range of 15 to 200 Formula: see text, the IMF power-law exponent is Formula: see text, shallower than the Salpeter value of 2.35.
Water pollution poses a global threat to ecosystems and human health and is driven by the presence of various contaminants in wastewater, including nano- and microplastics. Despite the magnitude of ...this problem, the majority of global wastewater is released untreated into water bodies. To combat this issue, a multi-strategy approach is needed. This study explores a circular economy-based solution for treating emerging pollutants, particularly wastewater from ophthalmic spectacle lens production. Our approach integrates solid waste materials into polymeric and cement matrices while also utilising wastewater for microalgae cultivation. This innovative strategy focuses on biomass generation and economic valorisation. By adopting a circular economy model, we aim to transform environmental pollutants from wastewater into valuable organic products. A key component of our approach is the utilisation of microalgae, specifically
sp., known for its high lipid content and resilience. This microalgae species serves as a promising biobased feedstock, supporting the production of innovative biobased products, such as biopolymers, for ophthalmic lens manufacturing. Our interdisciplinary approach combines microalgae technology, analytical chemistry, cement production, and polymer processing to develop a sustainable circular economy model that not only addresses environmental concerns, but also offers economic benefits. This study underscores the potential of harnessing high-value products from waste streams and underscores the importance of circular economy principles in tackling pollution and resource challenges.
Within the context of the collaboration “B fields in OB stars” (BOB), we used the FORS2 low-resolution spectropolarimeter to search for a magnetic field in 50 massive stars, including two reference ...magnetic massive stars. Because of the many controversies of magnetic field detections obtained with the FORS instruments, we derived the magnetic field values with two completely independent reduction and analysis pipelines. We compare and discuss the results obtained from the two pipelines. We obtained a general good agreement, indicating that most of the discrepancies on magnetic field detections reported in the literature are caused by the interpretation of the significance of the results (i.e., 3–4σ detections considered as genuine, or not), instead of by significant differences in the derived magnetic field values. By combining our results with past FORS1 measurements of HD 46328, we improve the estimate of the stellar rotation period, obtaining P = 2.17950 ± 0.00009 days. For HD 125823, our FORS2 measurements do not fit the available magnetic field model, based on magnetic field values obtained 30 years ago. We repeatedly detect a magnetic field for the O9.7V star HD 54879, the HD 164492C massive binary, and the He-rich star CPD −57 3509. We obtain a magnetic field detection rate of 6 ± 4%, while by considering only the apparently slow rotators we derive a detection rate of 8 ± 5%, both comparable with what was previously reported by other similar surveys. We are left with the intriguing result that, although the large majority of magnetic massive stars is rotating slowly, our detection rate is not a strong function of the stellar rotational velocity.
Approximately 10 per cent of massive OBA main-sequence (MS) and pre-MS stars harbour strong, large-scale magnetic fields. At the same time, there is a dearth of magnetic stars in close binaries. A ...process generating strong magnetic fields only in some stars must be responsible with the merging of pre-MS and MS stars being suggested as one such channel. Stars emerging from the coalescence of two MS stars are rejuvenated, appearing younger than they are. They can therefore be identified by comparison with reference clocks. Here, we predict the rejuvenation of MS merger products over a wide range of masses and binary configurations calibrated to smoothed-particle-hydrodynamical merger models. We find that the rejuvenation is of the order of the nuclear time-scale and is strongest in the lowest mass mergers and the most evolved binary progenitors with the largest mass ratios. These predictions allow us to put constraints on the binary progenitors of merger products. We show that the magnetic stars HR 2949 and τ Sco are younger than the potential binary companion HR 2948 and the Upper-Sco association, respectively, making them promising merger candidates. We find that the age discrepancies and the potential binary progenitors of both are consistent with them being rejuvenated merger products, implying that their magnetic fields may originate from this channel. Searching for age discrepancies in magnetic stars is therefore a powerful way to explore which fraction of magnetic stars may have obtained their strong magnetic field in MS mergers and to improve our understanding of magnetism in massive stars and their remnants.
Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal drug resistance, novel strategies are urgently needed to combat life-threatening fungal diseases. Here, we ...identify the host defense peptide mimetic, brilacidin (BRI) as a synergizer with caspofungin (CAS) against CAS-sensitive and CAS-resistant isolates of Aspergillus fumigatus, Candida albicans, C. auris, and CAS-intrinsically resistant Cryptococcus neoformans. BRI also potentiates azoles against A. fumigatus and several Mucorales fungi. BRI acts in A. fumigatus by affecting cell wall integrity pathway and cell membrane potential. BRI combined with CAS significantly clears A. fumigatus lung infection in an immunosuppressed murine model of invasive pulmonary aspergillosis. BRI alone also decreases A. fumigatus fungal burden and ablates disease development in a murine model of fungal keratitis. Our results indicate that combinations of BRI and antifungal drugs in clinical use are likely to improve the treatment outcome of aspergillosis and other fungal infections.
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bstract
An important aspect of the study of Quark-Gluon Plasma (QGP) in ultrarelativistic collisions of heavy ions is the ability to identify, in experimental data, a subset of the jets that were ...strongly modified by the interaction with the QGP. In this work, we propose studying Deep Learning techniques for this purpose. Samples of
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+jet events were simulated in vacuum (pp collisions) and medium (PbPb collisions) and used to train Deep Neural Networks with the objective of discriminating between
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jets within the medium (PbPb) sample. Dedicated Convolutional Neural Networks, Dense Neural Networks and Recurrent Neural Networks were developed and trained, and their performance was studied. Our results show the potential of these techniques for the identification of jet quenching effects induced by the presence of the QGP.