Deslorelin implants are widely used in felines. Due to their prolonged duration cat breeders frequently request early implant removal. The interval between deslorelin implant removal and resumption ...of ovarian function in queens is unknown. The aim of this study was to evaluate the interval between the removal of a deslorelin implant and the resumption of ovarian activity in adult queens. Twenty‐three queens were treated with a 4.7 mg deslorelin implant placed in the periumbilical area. In the 16 queens completing the study implants were surgically removed at 3, 6 or 9 months (n = 6, 4 and 6 queens, respectively). Queens received a GnRH stimulation test as part of their pre‐treatment general and reproductive health check. Following implantation treatment, all queens in inter‐oestrus–anoestrus at the time of treatment came in oestrus within 2–5 days. Starting 7–14 days following implant removal queens were checked every 1–2 weeks with reproductive ultrasonography, a vaginal smear and blood collection. The interval to resumption of ovarian function ranged from 3 to 7 weeks irrespective of treatment length and age of the queen but was longer when the implant was removed at decreasing photoperiod (p < .05). In conclusion, at least 3 weeks post‐removal are needed during increasing photoperiod to achieve follicular development and oestrogen production sufficient to support oestrous behaviour in queens following removal of a 4.7 mg deslorelin implant, while this time may increase up to 7 weeks during decreasing photoperiod. Further studies are needed to assess the interval between removal of a deslorelin implant and occurrence of ovulation as well as fertility at the first oestrus after a deslorelin treatment.
This is the first report about a vaginal leiomyoma concomitant with an ovarian luteoma in a bitch.
A 11-year-old intact female Labrador retriever was referred because of anuria, constipation and ...protrusion of a vaginal mass through the vulvar commissure. The bitch had high serum progesterone concentration (4.94 ng/ml). Because of the possibility of progesterone responsiveness causing further increase of the vaginal mass and since the bitch was a poor surgical candidate a 10 mg/kg aglepristone treatment was started SC on referral day 1. A computerized tomography showed a 12.7 × 6.5 × 8.3 cm mass causing urethral and rectal compression, ureteral dilation and hydronephrosis. A vaginal leiomyoma was diagnosed on histology. As serum progesterone concentration kept increasing despite aglepristone treatment, a 0.02 ng/mL twice daily IM alfaprostol treatment was started on day 18. As neither treatment showed remission of clinical signs or luteolysis, ovariohysterectomy was performed on referral day 35. Multiple corpora lutea were found on both ovaries. On histology a luteoma was diagnosed on the left ovary. P4 levels were undetectable 7 days after surgery. Recovery was uneventful and 12 weeks after surgery tomography showed a reduction of 86.7% of the vaginal mass. The bitch has been in good health and able to urinate without any complication ever since.
This case demonstrates the importance of identifying progesterone related conditions as well as the importance of judiciously using a combined medical and surgical approach.
The aim of this study was to develop and evaluate a pharmacokinetic model-driven infusion of propofol in premedicated cats. In a first step, propofol (10 mg/kg) was administered intravenously over 60 ...seconds to induce anaesthesia for the elective neutering of seven healthy cats, premedicated intramuscularly with 0.3 mg/kg methadone, 0.01 mg/kg medetomidine and 2 mg/kg ketamine. Venous blood samples were collected over 240 minutes, and propofol concentrations were measured via a validated high-performance liquid chromatography assay. Selected pharmacokinetic parameters, determined by a three-compartment open linear model, were entered into a computer-controlled infusion pump (target-controlled infusion-1 (TCI-1)). In a second step, TCI-1 was used to induce and maintain general anaesthesia in nine cats undergoing neutering. Predicted and measured plasma concentrations of propofol were compared at specific time points. In a third step, the pharmacokinetic parameters were modified according to the results from the use of TCI-1 and were evaluated again in six cats. For this TCI-2 group, the median values of median performance error and median absolute performance error were −1.85 per cent and 29.67 per cent, respectively, indicating that it performed adequately. Neither hypotension nor respiratory depression was observed during TCI-1 and TCI-2. Mean anaesthesia time and time to extubation in the TCI-2 group were 73.90 (±20.29) and 8.04 (±5.46) minutes, respectively.
A 10-year-old, 6-kg male Yorkshire terrier dog was scheduled for routine dental cleaning. No significant problem was observed either during anaesthesia, which was induced with propofol, or during ...recovery. However, 2 hours after discharge, the dog's owner returned to the clinic, complaining that the animal was lethargic and had had bloody diarrhoea. On physical examination the dog was depressed, dyspnoeic, tachycardic and hypoglycaemic. Despite supportive treatment, the dog deteriorated and died within a few hours.A presumed diagnosis of sepsis was confirmed by laboratory testing. Bacteriological and molecular examinations of both premortem blood samples and the anaesthetic, highlighted the presence of Ochrobactrum anthropi, an opportunistic pathogen usually associated with immunocompromised hosts with indwelling medical devices. To the authors’ knowledge, this is the first case of sepsis in a healthy dog due to contamination of an anaesthetic solution by O. anthropi, suggesting a potential role of this microorganism as an emerging pathogen.
The Silicon Strip Tracker (SST) for the CMS experiment at LHC consists of 210
m
2 of silicon strip detectors grouped into four distinct sub-systems. We present a brief description of the CMS Tracker, ...the industrialised detector module production methods and the current status of the SST with reference to some problems encountered at the factories and in the construction centres.
In this work we prove global solution for the nonlinear system utt−Δpu+θ=|u|r−1uθt−Δθ=utwhere Δp is the nonlinear p-Laplacian operator, 2≤p<∞. We apply the potential well theory. The global solution ...is constructed by means of the Faedo–Galerkin approximations, taking into account that the initial data is in appropriated set of stability created from the Nehari manifold.
Objectives
The aim of this retrospective study was to describe the spinal anaesthesia (SA) technique and evaluate the incidence of perioperative complications in cats.
Methods
The anaesthetic records ...of cats of American Society of Anaesthesiologists physical status I, II and III, which received general and SA for different surgeries between 2012 and 2016, were examined. SA was administered through a 25 G Quincke needle, using an isobaric solution of bupivacaine and morphine at the level of either the L7–S1 interspaces (sternal recumbency) or the L5–6/L6–7 interspaces (lateral recumbency). Procedural failure rate (PFR), drugs and dose used, heart rate (HR), arterial blood pressure, incidence of bradycardia (HR <100 bpm) and hypotension (mean arterial pressure MAP <60 mmHg for at least 5 mins), intraoperative rescue analgesia (iRA) and any other detrimental events and their treatment until discharge were recorded. Abdominal surgery cases were excluded from the intraoperative evaluation.
Results
A total of 58 anaesthetic records met the inclusion criteria and were analysed. PFR related to the space of injection (L7–S1 vs L5–6/L6–7) was 3/11 (27%) and 1/47 (2%), respectively (P = 0.017). The total median dose of intrathecal bupivacaine and morphine was 0.8 (range 0.5–1.6 mg/kg) and 0.10 (0.05–0.18 mg/kg), respectively. Nine of 46 (20%) cats received iRA, and no iRA cases were reported with a dose of bupivacaine higher than 0.8 mg/kg. Median HR and MAP before intrathecal injection (T0) and 10 mins after (T1) were, respectively, 118 bpm (range 74–190 bpm) and 106 bpm (67–160 bpm) (P = 0.005), and 65 mmHg (range 50–94 mmHg) and 52 mmHg (range 35–85 mmHg) (P = 0.003). Bradycardia was reported in 18/46 (39%) cats and hypotension in 23/46 (50%) cats. No complications were recorded during the observation period.
Conclusions and relevance
SA was characterised by a low PFR when performed at the L5–6/L6–7 interspaces and low postoperative complications. Hypotension and bradycardia were the most common side effects.
Strip ionization chambers as 3-D detector for hadron therapy Brusasco, C.; Cattai, A.; Cirio, R. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/1997, Letnik:
389, Številka:
3
Journal Article
Recenzirano
The design and construction of a set of parallel plate ionization chambers with one of the electrodes segmented in strips are presented. The performances of the chambers as from a test on a 270 MeV/
...u
12C
−16 beam are reported in view of their use in a 3-D dosimeter for therapeutical hadron beams.
Thirty-two large-area Micro-Strip Gas Chambers were tested in a high-intensity, 350 MeV pion beam at PSI to prove that we had reached a Milestone for the Compact Muon Solenoid (CMS) experiment. The ...particle rate was approximately
6
kHz/
mm
2
, distributed over the whole active area of the detectors, and this rate was maintained for a total integrated time of 493 h. All of the chambers were operated with signal-to-noise values at or above that corresponding to 98% hit detection efficiency at CMS; the average
S/
N was 31. No indications of any gain instabilities or ageing effects were observed. In the official 3-week Milestone period, three strips from a total of 16
384 were damaged, a result which is 20 times lower than the minimal requirement for CMS. The spark rate of the detectors was very low and decreased with time to an average of one spark per chamber per day. The cathode voltages of 24 of the chambers were increased over a one week period to investigate the behaviour of the detectors at higher gains; the maximum
S/
N value was 2.4 times that at the normal working point. No significant increase in spark rate or strip loss rate was detected and the chambers operated stably. The detector efficiencies and imaging capabilities were also investigated. The MSGC design features and the assembly and test methodologies that enabled us to achieve these results are reported.
A method is described for the characterization and counting of discharges in MSGCs. It is shown that the technique is sensitive enough to detect the micro-discharges which occur prior to full ...sparking, with a detection efficiency of 0.8. Some example results are presented, showing the variation of micro-discharge rate with gain.
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