Abstract
In winter, a branch of the China Coastal Current can turn in the Taiwan Strait to join the poleward-flowing Taiwan Coastal Current. The associated cross-strait flows have been inferred from ...hydrographic and satellite data, from observed abundances off northwestern Taiwan of cold-water copepod species Calanus sinicus and, in late March of 2012, also from debris found along the northwestern shore of Taiwan of a ship that broke two weeks earlier off the coast of China. The dynamics related to such cross flows have not been previously explained and are the focus of this study using analytical and numerical models. It is shown that the strait’s currents can be classified into three regimes depending on the strength of the winter monsoon: equatorward (poleward) for northeasterly winds stronger (weaker) than an upper (lower) bound and cross-strait flows for relaxing northeasterly winds between the two bounds. These regimes are related to the formation of the stationary Rossby wave over the Changyun Ridge off midwestern Taiwan. In the weak (strong) northeasterly wind regime, a weak (no) wave is produced. In the relaxing wind regime, cross-strait currents are triggered by an imbalance between the pressure gradient and wind and are amplified by the finite-amplitude meander downstream of the ridge where a strong cyclone develops.
Hypoxia plays a critical role during the evolution of malignant cells and tumour microenvironment (TME).Tumour-derived exosomes contain informative microRNAs involved in the interaction of cancer and ...stromal cells, thus contributing to tissue remodelling of tumour microenvironment. This study aims to clarify how hypoxia affects tumour angiogenesis through exosomes shed from lung cancer cells. Lung cancer cells produce more exosomes under hypoxic conditions than do parental cells under normoxic conditions. miR-23a was significantly upregulated in exosomes from lung cancer under hypoxic conditions. Exosomal miR-23a directly suppressed its target prolyl hydroxylase 1 and 2 (PHD1 and 2), leading to the accumulation of hypoxia-inducible factor-1 α (HIF-1 α) in endothelial cells. Consequently, hypoxic lung cancer cells enhanced angiogenesis by exosomes derived from hypoxic cancer under both normoxic and hypoxic conditions. In addition, exosomal miR-23a also inhibits tight junction protein ZO-1, thereby increasing vascular permeability and cancer transendothelial migration. Inhibition of miR-23a by inhibitor administration decreased angiogenesis and tumour growth in a mouse model. Furthermore, elevated levels of circulating miR-23a are found in the sera of lung cancer patients, and miR-23a levels are positively correlated with proangiogenic activities. Taken together, our study reveals the clinical relevance and prognostic value of cancer-derived exosomal miR-23a under hypoxic conditions, and investigates a unique intercellular communication, mediated by cancer-derived exosomes, which modulates tumour vasculature.
The long-term outcome of 1390 children with acute lymphoblastic leukemia (ALL), treated in two successive clinical trials (Taiwan Pediatric Oncology Group (TPOG)-ALL-97 and TPOG-ALL-2002) between ...1997 and 2007, is reported. The event-free survival improved significantly (P=0.0004) over this period, 69.3+/-1.9% in 1997-2001 to 77.4+/-1.7% in 2002-2007. A randomized trial in TPOG-97 testing L-asparaginase versus epidoxorubicin in combination with vincristine and prednisolone for remission induction in standard-risk (SR; low-risk) patients yielded similar outcomes. Another randomized trial, in TPOG-2002, showed that for SR patients, two reinduction courses did not improve long-term outcome over one course. Decreasing use of prophylactic cranial irradiation in the period 1997-2008 was not associated with increased rates of CNS relapse, prompting complete omission of prophylactic cranial irradiation from TPOG protocols, beginning in 2009. Decreased use of etoposide and cranial irradiation likely contributed to the low incidence of second cancers. High-risk B-lineage ALL, T-cell, CD10 negativity, t(9;22), infant, and higher leukocyte count were consistently adverse factors, whereas hyperdiploidy >50 was a consistently favorable factor. Higher leukocyte count and t(9;22) retained prognostic significance in both TPOG-97 and TPOG-2002 by multivariate analysis. Although long-term outcome in TPOG clinical trials is comparable with results being reported worldwide, the persistent strength of certain prognostic variables and the lower frequencies of favorable outcome predictors, such as ETV6-RUNX1 and hyperdiploidy >50, in Taiwanese children warrant renewed effort to cure a higher proportion of patients while preserving their quality of life.
In recent decades, wintertime sea surface temperatures off the eastern coast of China have steadily increased. The warming is accompanied by on‐coast wind convergence across East China Sea and by ...stronger northeasterly wind which is spatially inhomogeneous being greatest in the Taiwan Strait. Strong winds favor more frequent cross‐shelf currents and vigorous spreading of heat from the Kuroshio, which warms the coastal sea in a positive feedback loop. The process also weakens the East Asian winter monsoon over eastern China, contributing to its decoupling from the recent rebound of the Siberian High.
Key Points
Recent warming off coastal China is accompanied by stronger northeasterly wind
Stronger winter monsoon spreads heat from Kuroshio producing air‐sea response
The increased wind is detached from the recent rebound of the Siberian High
Tide gauge and satellite data reveal an interannual oscillation of the ocean’s thermoclines east of the Philippines and Taiwan, forced by a corresponding oscillation in the wind stress curl. This ...so-called Philippines–Taiwan Oscillation (PTO) is shown to control the interannual variability of the circulation of the subtropical and tropical western North Pacific. The PTO shares some characteristics of known Pacific indices, for example, Niño-3.4. However, unlike PTO, these other indices explain only portions of the western North Pacific circulation. The reason is because of the nonlinear nature of the forcing in which mesoscale (ocean) eddies play a crucial role. In years of positive PTO, the thermocline east of the Philippines rises while east of Taiwan it deepens. This results in a northward shift of the North Equatorial Current (NEC), increased vertical shear of the Subtropical Countercurrent (STCC)/NEC system, increased eddy activity dominated by warm eddies in the STCC, increased Kuroshio transport off the northeastern coast of Taiwan into the East China Sea, increased westward inflow through Luzon Strait into the South China Sea, and cyclonic circulation and low sea surface height anomalies in the South China Sea. The reverse applies in years of negative PTO.
Twenty‐nine years of tide‐gauge data are analyzed in conjunction with wind and satellite‐derived sea‐surface height and ocean velocity data to study the interannual and seasonal variations of the ...Kuroshio transport off the northeastern coast of Taiwan. The data reveals an interannual variation of ±0.1 m (transport‐variation of approximately ±3.5 Sv; 1 Sv = 106 m3 s−1), and a much weaker (5–10 times weaker) seasonal fluctuation that is minimum in May and maximum in November. The interannual fluctuations are not directly wind‐driven by linear dynamics; rather, the Kuroshio strengthens in years of abundant eddies of the Subtropical Counter Current, which is related to the current's instability state driven by the slow fluctuations of the large‐scale wind stress curl in the western Pacific. The seasonal transport fluctuation is also eddy‐forced, but has weaker amplitude because the seasonal time scale is of the same order as the eddy‐propagation time scale, and transport‐producing eddy signals tend to overlap east of Taiwan.
Key Points
Interannual Kuroshio variations
Eddy‐driven dynamics
Far‐reaching impacts on western Pacific
The observed seasonal preferences of Loop Current eddy shedding, more in summer and winter and less in fall and spring, are shown for the first time to be due to a curious combination of forcing by ...the seasonal winds in the Caribbean Sea and the Gulf of Mexico. The conditions are favorable for the Loop to shed eddies in summer and winter when strong trade winds in the Caribbean produce large Yucatan transport and Loop's intrusion, and concurrently when weak easterlies in the Gulf offer little impediment to eddy shedding. The conditions are less favorable in fall and spring as the trade winds and Yucatan transport weaken, and the strengthening of the Gulf's easterlies impedes shedding.
Key Points
The observed seasonal preferences of Loop Current eddy shedding, more in summer
The preference is forced, instead of the natural shedding
It is due to the be due to a curious combination of forcing by the seasonal wind
Abstract
Air–sea coupling in the IntraAmerican seas (IAS; Caribbean Sea and Gulf of Mexico) is studied through analyses of observational data from satellite, reanalysis products, and in situ ...measurements. A strong coupling is found between the easterly trade wind −U and meridional SST gradient ∂T/∂y across a localized region of the southern-central Caribbean Sea from seasonal and interannual to decadal time scales. The ∂T/∂y anomaly is caused by a variation in the strength of coastal upwelling off the Venezuelan coast by the wind, which in turn strengthens (weakens) for stronger (weaker) ∂T/∂y. Wind speeds and seasonal fluctuations in IAS have increased in the past two decades with a transition near 1994 coinciding approximately with when the Atlantic multidecadal oscillation (AMO) turned from cold to warm phases. In particular, the seasonal swing from summer's strong to fall's weak trade wind has become larger. The ocean's upper-layer depth has also deepened, by as much as 50% on average in the eastern Gulf of Mexico. These conditions favor the shedding of eddies from the Loop Current, making it more likely to shed at a biannual frequency, as has been observed from altimetry data.
Abstract
The North Pacific Subtropical Countercurrent (STCC) has a weak eastward velocity near the surface, but the region is populated with eddies. Studies have shown that the STCC is baroclinically ...unstable with a peak growth rate of 0.015 day−1 in March, and the ~60-day growth time has been used to explain the peak eddy kinetic energy (EKE) in May observed from satellites. It is argued here that this growth time from previously published normal-mode instability analyses is too slow. Growth rates calculated from an initial-value problem without the normal-mode assumption are found to be 1.5 to 2 times faster and at shorter wavelengths, due to the existence of (i) nonmodal solutions and (ii) sea surface temperature front in the mixed layer in winter. At interannual time scales it is shown that because of rapid surface adjustments, the STCC geostrophic shear, hence also the instability growth, is approximately in phase with surface forcing, leading to EKE modulation that peaks approximately 10 months later. However, the EKE can only be partially explained by this mechanism of modulation by baroclinic instability. It is suggested that the unexplained variance may be caused additionally by modulation of the EKE by dissipation.
To understand the status of oropharyngeal yeast colonization in human immunodeficiency virus (HIV) -infected outpatients in the era of highly active antiretroviral therapy (HAART), we conducted a ...prospective, cross-sectional study from October 2009 to January 2010 at a medical centre in southern Taiwan. Fungal cultures of the oropharyngeal swabs were performed on 327 enrolled patients. At enrolment, 258 (79%) patients had been receiving HAART, and 42 (12.8%), 73 (22.3%) and 212 (64.8%) patients had CD4 cell counts ≤200, 201–350, and >350 cells/mm3, respectively. Oral yeast colonization was detected in 193 (59%) patients, among whom 157 (81.3%), 25 (13.0%), and 11 (5.7%) were colonized by a single, two and more than two species, respectively. Multivariate analysis showed that receipt of efavirenz-containing regiments and CD4 cell counts >200 cells/mm3 were associated with lower risks of oral yeast colonization, while intravenous drug users were at a higher risk. Among the 241 isolates recovered, Candida albicans accounted for 69.7%, followed by C. dubliniensis (9.5%), C. glabrata (8.3%), C. tropicalis (3.3%), C. intermedia (2.1%), C. parapsilosis (1.7%), and 11 other species (5.4%). Overall, 230 (95.4%), 236 (97.9%) and 240 (99.6%) isolates were susceptible to fluconazole, voriconazole and amphotericin B, respectively. In conclusion, colonization by C. dubliniensis has emerged in recent years. In addition to a CD4 cell count ≤200 cells/mm3, which is a known risk factor for oropharyngeal yeast colonization in HIV-infected patients that was identified in our previous studies, two risk factors, non-receipt of efavirenz-based combinations and intravenous drug use, were first identified in the present study. Fluconazole remained effective in vitro against the yeasts colonizing the oropharynx in this population.
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