This is the second paper in a series where we examine the physics of pair producing gaps in low-luminosity accreting supermassive black hole systems. In this paper, we carry out time-dependent ...self-consistent fully general relativistic 1D particle-in-cell simulations of the gap, including full inverse Compton scattering and photon tracking. Similar to the previous paper, we find a highly time-dependent solution where a macroscopic vacuum gap can open quasiperiodically, producing bursts of pairs and high energy radiation. We present the light curve, particle spectrum, and photon spectrum from this process. Using an empirical scaling relation, we rescale the parameters to the inferred values at the base of the jet in M87, and find that the observed TeV flares could potentially be explained by this model under certain parameter assumptions.
In contrast to over 30 studies reporting neurotoxicity associated with the first-generation antipsychotics (FGAs), several published studies have reported multiple neuroprotective effects associated ...with the second generation antipsychotics (SGAs). This prompted us to conduct a review of the reported neuroprotective mechanisms of the SGA class of antipsychotics compared to the FGAs.
A PubMed search was conducted using the keywords antipsychotic, neuroprotection, neuroplasticity, neurogenesis, neurotoxicity, toxicity, brain volume, neuroinflammation, oxidative stress, myelin, and oligodendrocyte. No restrictions were placed on the date of the articles or language. Studies with a clearly described methodology were included.
Animal, cell culture, and human clinical studies were identified. Twenty-four reports met the criteria for the search. All studies included at least one SGA (aripiprazole, clozapine, lurasidone, olanzapine, paliperidone, perospirone, quetiapine, risperidone, and/or ziprasidone). A few also included FGAs as a comparator (predominantly haloperidol). All studies demonstrated at least one neuroprotective mechanism of one or more SGAs, while some studies also showed that FGAs ranged from having no neuroprotective effects to actually exerting neurotoxic effects leading to neuronal death.
A review of the literature suggests that in addition to their antipsychotic efficacy and low motoric side effects, SGAs exert measurable neuroprotective effects mediated via multiple molecular mechanisms and often in a dose-dependent manner. The neuroprotective effects of SGAs range from preventative to restorative and may play a salutary role in ameliorating the neurodegenerative effects of psychosis.
Using numerical simulations we show that low-amplitude Alfvén waves from a magnetar quake propagate to the outer magnetosphere and convert to "plasmoids" (closed magnetic loops) that accelerate from ...the star, driving blast waves into the magnetar wind. Quickly after its formation, the plasmoid becomes a thin relativistic pancake. It pushes out the magnetospheric field lines, and they gradually reconnect behind the pancake, generating a variable wind far stronger than the normal spindown wind of the magnetar. Repeating ejections drive blast waves in the amplified wind. We suggest that these ejections generate the simultaneous X-ray and radio bursts detected from SGR 1935+2154. A modest energy budget of the magnetospheric perturbation ∼1040 erg is sufficient to produce the observed bursts. Our simulation predicts a narrow (a few milliseconds) X-ray spike from the magnetosphere, arriving almost simultaneously with the radio burst emitted far outside the magnetosphere. This timing is caused by the extreme relativistic motion of the ejecta.
Abstract It was recently proposed that the electric field oscillation as a result of self-consistent e ± pair production may be the source of coherent radio emission from pulsars. Direct ...particle-in-cell simulations of this process have shown that the screening of the parallel electric field by this pair cascade manifests as a limit cycle, as the parallel electric field is recurrently induced when pairs produced in the cascade escape from the gap region. In this work, we develop a simplified time-dependent kinetic model of e ± pair cascades in pulsar magnetospheres that can reproduce the limit-cycle behavior of pair production and electric field screening. This model includes the effects of a magnetospheric current, the escape of e ± , as well as the dynamic dependence of pair production rate on the plasma density and energy. Using this simple theoretical model, we show that the power spectrum of electric field oscillations averaged over many limit cycles is compatible with the observed pulsar radio spectrum.
The magnetospheres of magnetars are believed to be filled with electron-positron plasma generated by electric discharge. We present a first numerical experiment demonstrating this process in an ...axisymmetric magnetosphere with a simple threshold prescription for pair creation, which is applicable to the inner magnetosphere with an ultrastrong field. The discharge occurs in response to the twisting of the closed magnetic field lines by a shear deformation of the magnetar surface, which launches electric currents into the magnetosphere. The simulation shows the formation of an electric "gap" with an unscreened electric field ( ) that continually accelerates particles along the magnetic field lines and sustains pair creation. The accelerating voltage is self-regulated to the threshold of the discharge. It controls the rate of energy release and the lifetime of the magnetic twist. The simulation follows the global evolution of the twisted magnetosphere over a long time and demonstrates its gradual resistive untwisting. A vacuum cavity forms near the star and expands, gradually erasing magnetospheric electric currents j. The active j-bundle shrinks with time and its footprints form shrinking hot spots on the magnetar surface bombarded by the created particles.
Thin films based on two-dimensional metal halide perovskites have achieved exceptional performance and stability in numerous optoelectronic device applications. Simple solution processing of the 2D ...perovskite provides opportunities for manufacturing devices at drastically lower cost compared to current commercial technologies. A key to high device performance is to align the 2D perovskite layers, during the solution processing, vertical to the electrodes to achieve efficient charge transport. However, it is yet to be understood how the counter-intuitive vertical orientations of 2D perovskite layers on substrates can be obtained. Here we report a formation mechanism of such vertically orientated 2D perovskite in which the nucleation and growth arise from the liquid-air interface. As a consequence, choice of substrates can be liberal from polymers to metal oxides depending on targeted application. We also demonstrate control over the degree of preferential orientation of the 2D perovskite layers and its drastic impact on device performance.
In some low-luminosity accreting supermassive black hole systems, the supply of plasma in the funnel region can be a problem. It is believed that a local region with an unscreened electric field can ...exist in the black hole magnetosphere, accelerating particles and producing high-energy gamma-rays that can create e pairs. We carry out time-dependent self-consistent 1D PIC simulations of this process, including inverse-Compton scattering and photon tracking. We find a highly time-dependent solution where a macroscopic gap opens quasi-periodically to create e pairs and high-energy radiation. If this gap is operating at the base of the jet in M87, we expect an intermittency on the order of a few rg/c, which coincides with the timescale of the observed TeV flares from the same object. For Sagittarius A* the gap electric field can potentially grow to change the global magnetospheric structure, which may explain the lack of a radio jet at the center of our galaxy.
We present the first self-consistent global simulations of pulsar magnetospheres with operating e super(+ or -) discharge. We focus on the simple configuration of an aligned or anti-aligned rotator. ...The star is spun up from a zero (vacuum) state to a high angular velocity, and we follow the coupled evolution of its external electromagnetic field and plasma particles using the "particle-in-cell" method. A plasma magnetosphere begins to form through the extraction of particles from the star; these particles are accelerated by the rotation-induced electric field, producing curvature radiation and igniting e discharge. We follow the system evolution for several revolution periods, longer than required to reach a quasi-steady state. Our numerical experiment puts to test previous ideas for the plasma flow and gaps in the pulsar magnetosphere. We first consider rotators capable of producing pairs out to the light cylinder through photon-photon collisions. We find that their magnetospheres are similar to the previously obtained force-free solutions with a Y-shaped current sheet. The magnetosphere continually ejects e pairs and ions. Pair creation is sustained by a strong electric field along the current sheet. We observe powerful curvature and synchrotron emission from the current sheet, consistent with Fermi observations of gamma-ray pulsars. We then study pulsars that can only create pairs in the strong-field region near the neutron star, well inside the light cylinder. We find that both aligned and anti-aligned rotators relax to the "dead" state with suppressed pair creation and electric currents, regardless of the discharge voltage.
Recent modeling of Neutron Star Interior Composition Explorer (NICER) observations of the millisecond pulsar PSR J0030+0451 suggests that the magnetic field of the pulsar is non-dipolar. We construct ...a magnetic field configuration where foot points of the open field lines closely resemble the hotspot configuration from NICER observations. Using this magnetic field as input, we perform force-free simulations of the magnetosphere of PSR J0030+0451, showing the three-dimensional structure of its plasma-filled magnetosphere. Making simple and physically motivated assumptions about the emitting regions, we are able to construct the multiwavelength lightcurves that qualitatively agree with the corresponding observations. The agreement suggests that multipole magnetic structures are the key to modeling this type of pulsar, and can be used to constrain the magnetic inclination angle and the location of radio emission.
PDF
