Mobile cloud computing is envisioned as a promising approach to augment computation capabilities of mobile devices for emerging resource-hungry mobile applications. In this paper, we propose a game ...theoretic approach for achieving efficient computation offloading for mobile cloud computing. We formulate the decentralized computation offloading decision making problem among mobile device users as a decentralized computation offloading game. We analyze the structural property of the game and show that the game always admits a Nash equilibrium. We then design a decentralized computation offloading mechanism that can achieve a Nash equilibrium of the game and quantify its efficiency ratio over the centralized optimal solution. Numerical results demonstrate that the proposed mechanism can achieve efficient computation offloading performance and scale well as the system size increases.
The online health community has the functions of online consultation, health record management and disease information interaction as an online medical platform. In the context of the pandemic, the ...existence of online health communities has provided a favorable environment for information acquisition and knowledge sharing among different roles, effectively improving the health of human, and popularizing health knowledge. This paper analyzes the development and importance of domestic online health communities, and sorts out users' participation behaviors, types of behaviors, and continuous participation behaviors, influence motives, and motivational patterns in online health communities. Taking the operation status of the online health community during the pandemic period as an example, the computer sentiment analysis method was used to obtain seven categories of participation behaviors and the proportion of various behaviors of online health community users, and the conclusion is: the emergence of the pandemic, making the online health community a platform where people are more inclined to choose to consult health issues, and user interaction behaviors have become more active on the platform.
•A MOF with plentiful Cl atoms hanging on the pore surface was successfully built.•The inverse CO2/C2H2 separation was achieved by inserting Cl atoms in the MOF.•Impact of Cl atoms toward adsorb CO2 ...and C2H2 is evidenced by simulations.
Selective isolation of CO2 from C2H2 using CO2-selective adsorbent is a huge challenge due to their analogous physical properties as well as molecular sizes and shapes. In this work, utilizing an effective strategy of embedding electronegative Cl atoms in pore surface of MOF, a 3D pillared-layer ultramicroporous MOF, Zn(atz)(BDC-Cl4)0.5n(1) (Hatz = 3-amino-1,2,4-triazole; BDC-Cl4 = tetrachloroterephthalic acid) for inverse CO2/C2H2 separation was successfully constructed. This MOF show a CO2/C2H2 (V:V = 1:1) adsorption selectivity of 2.4 at 285 K and 100 kPa. Computational studies further uncover CO2 recognition mechanism is due to the matching of the unique pore environment decorating by Cl atoms with quadrupole moment of CO2.
Bioinspired smart materials with synergistic allochroic luminescence and complex deformation are expected to play an important role in many areas of science and technology. However, it is still ...challenging to fabricate such soft actuators with high programmability that can be manipulated in situ with high spatial resolution. Herein, we have incorporated terminally functionalized aggregation‐induced emission active tetraphenylethene derivative and photochromic spiropyran moieties into the networks of liquid crystal elastomers through covalent bonding to obtain the synergistic photochromic luminescence and programmable soft actuators. Bio‐mimic functions and light‐induced auxetic metamaterial‐like devices were shown to be feasible based on the combination of assembly and origami‐programming strategy. These bioinspired devices with synergistic photochromic luminescence and complex photodeformation abilities provide an elegant strategy to design multi‐functional liquid crystal actuators.
Inspired by the synergic allochroic and shape‐morphing bio‐functions like caterpillars and cephalopods, photochromic luminescent liquid crystal actuators were prepared. Complex movements and fluorescent colors can be synergically manipulated by light based on the phase transition of liquid crystals and photoresponse of the fluorescent chromophores after the actuators were programmed with hybrid mesogenic alignments.
Psychological health problems, especially emotional disorders, are common among adolescents. The epidemiology of emotional disorders is greatly influenced by stressful events. This study sought to ...assess the prevalence rate and socio-demographic correlates of depressive and anxiety symptoms among Chinese adolescents affected by the outbreak of COVID-19. We conducted a cross-sectional study among Chinese students aged 12–18 years during the COVID-19 epidemic period. An online survey was used to conduct rapid assessment. A total of 8079 participants were involved in the study. An online survey was used to collect demographic data, assess students’ awareness of COVID-19, and assess depressive and anxiety symptoms with the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) questionnaire, respectively. The prevalence of depressive symptoms, anxiety symptoms, and a combination of depressive and anxiety symptoms was 43.7%, 37.4%, and 31.3%, respectively, among Chinese high school students during the COVID-19 outbreak. Multivariable logistic regression analysis revealed that female gender was the higher risk factor for depressive and anxiety symptoms. In terms of grades, senior high school was a risk factor for depressive and anxiety symptoms; the higher the grade, the greater the prevalence of depressive and anxiety symptoms. Our findings show there is a high prevalence of psychological health problems among adolescents, which are negatively associated with the level of awareness of COVID-19. These findings suggest that the government needs to pay more attention to psychological health among adolescents while combating COVID-19.
The recent advance of single-cell technologies has brought new insights into complex biological phenomena. In particular, genome-wide single-cell measurements such as transcriptome sequencing enable ...the characterization of cellular composition as well as functional variation in homogenic cell populations. An important step in the single-cell transcriptome analysis is to group cells that belong to the same cell types based on gene expression patterns. The corresponding computational problem is to cluster a noisy high dimensional dataset with substantially fewer objects (cells) than the number of variables (genes).
In this article, we describe a novel algorithm named shared nearest neighbor (SNN)-Cliq that clusters single-cell transcriptomes. SNN-Cliq utilizes the concept of shared nearest neighbor that shows advantages in handling high-dimensional data. When evaluated on a variety of synthetic and real experimental datasets, SNN-Cliq outperformed the state-of-the-art methods tested. More importantly, the clustering results of SNN-Cliq reflect the cell types or origins with high accuracy.
The algorithm is implemented in MATLAB and Python. The source code can be downloaded at http://bioinfo.uncc.edu/SNNCliq.
Cancer‐associated mesenchymal stem cells (MSCs) play a pivotal role in modulating tumor progression. However, the interactions between liver cancer‐associated MSCs (LC‐MSCs) and hepatocellular ...carcinoma (HCC) remain unreported. Here, we identified the presence of MSCs in HCC tissues. We also showed that LC‐MSCs significantly enhanced tumor growth in vivo and promoted tumor sphere formation in vitro. LC‐MSCs also promoted HCC metastasis in an orthotopic liver transplantation model. Complementary DNA (cDNA) microarray analysis showed that S100A4 expression was significantly higher in LC‐MSCs compared with liver normal MSCs (LN‐MSCs) from adjacent cancer‐free tissues. Importantly, the inhibition of S100A4 led to a reduction of proliferation and invasion of HCC cells, while exogenous S100A4 expression in HCC cells resulted in heavier tumors and more metastasis sites. Our results indicate that S100A4 secreted from LC‐MSCs can promote HCC cell proliferation and invasion. We then found the expression of oncogenic microRNA (miR)‐155 in HCC cells was significantly up‐regulated by coculture with LC‐MSCs and by S100A4 ectopic overexpression. The invasion‐promoting effects of S100A4 were significantly attenuated by a miR‐155 inhibitor. These results suggest that S100A4 exerts its effects through the regulation of miR‐155 expression in HCC cells. We demonstrate that S100A4 secreted from LC‐MSCs promotes the expression of miR‐155, which mediates the down‐regulation of suppressor of cytokine signaling 1, leading to the subsequent activation of STAT3 signaling. This promotes the expression of matrix metalloproteinases 9, which results in increased tumor invasiveness. Conclusion: S100A4 secreted from LC‐MSCs is involved in the modulation of HCC progression, and may be a potential therapeutic target. (HEPATOLOGY 2013)
Overcoming the resistance to apoptosis and immunosuppression of tumor cells is a significant challenge in augmenting the effect of cancer immunotherapy. Pyroptosis, a lytic programmed cell‐death ...pathway unlike apoptosis, is considered a type of immunogenic cell death (ICD) that can intensify the ICD process in tumor cells, releasing dramatically increased tumor‐associated antigens and damage‐associated molecular patterns to promote cancer immunotherapy. Herein, a tumor cell membrane‐targeted aggregation‐induced emission photosensitive dimer is found to be able to achieve highly efficient ICD under the synergistic effect of photodynamic and photothermal therapy. The photosensitive dimer can efficiently produce type‐I reactive oxygen species (ROS) by photodynamic therapy in hypoxic tumor tissue, leading to pyroptosis by direct cell membrane damage, which is further reinforced by its photothermal effect. Furthermore, the enhanced ICD effect based on the dimer can completely eliminate the primary tumor on the seventh day of treatment and can also boost systemic antitumor immunity by generating immune memory, which is demonstrated by the superior antitumor therapeutic effects on both solid tumors and metastatic tumors when healing 4T1 tumor mouse models with poor immunogenicity.
A membrane‐targeted photosensitive dimer, which effectively generates type‐I reactive oxygen species in hypoxic tumor tissue for pyroptosis‐mediated photoimmunotherapy, is successfully developed. Its remarkable photothermal properties accelerate the pyroptosis process, increase DNA damage in tumor cells, generate drastic immunogenic cell death and systemic antitumor immune response, and prevent tumor recurrence and metastasis.
Although deep neural networks (DNNs) have been widely applied to hyperspectral image (HSI) denoising, most DNN-based HSI denoising methods are designed by stacking convolution layer, which can only ...model and reason local relations, and thus ignore the global contextual information. To address this issue, we propose a deep spatial-spectral global reasoning network to consider both the local and global information for HSI noise removal. Specifically, two novel modules are proposed to model and reason global relational information. The first one aims to model global spatial relations between pixels in feature maps, and the second one models the global relations across the channels. Compared to traditional convolution operations, the two proposed modules enable the network to extract representations from new dimensions. For the HSI denoising task, the two modules, as well as the densely connected structures, are embedded into the U-Net architecture. Thus, the new-designed global reasoning network can help tackle complex noise by exploiting multiple representations, e.g., hierarchical local feature, global spatial coherence, cross-channel correlation, and multi-scale abstract representation. Experiments on both synthetic and real HSI data demonstrate that our proposed network can obtain comparable or even better denoising results than other state-of-the-art methods.
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