The objective of this paper is to propose a new inverter topology for a multilevel voltage output. This topology is designed based on a switched capacitor (SC) technique, and the number of output ...levels is determined by the number of SC cells. Only one dc voltage source is needed, and the problem of capacitor voltage balancing is avoided as well. This structure is not only very simple and easy to be extended to a higher level, but also its gate driver circuits are simplified because the number of active switches is reduced. The operational principle of this inverter and the targeted modulation strategies are presented, and power losses are investigated. Finally, the performance of the proposed multilevel inverter is evaluated with the experimental results of an 11-level prototype inverter.
Purpose
This study aimed to compare the symptoms, unmet needs, and QoL reported by women at 6 months to <2 years and 2 to 5 years following surgery and adjuvant treatment for breast cancer. It also ...evaluated the relationships among symptoms, unmet needs, and QoL using structural equation modeling.
Methods
In this study, 113 and 137 survivors following breast cancer treatment 6 months to <2 years and 2 to 5 years, respectively, completed the Memorial Symptom Assessment Scale, the Supportive Care Needs Survey-34, and the Medical Outcomes Study 12-item Short Form Health Survey version 2.0 during their medical follow-up.
Results
The mean numbers of symptoms and unmet needs were 5.43 and 3.0, respectively, for survivors at <2 years, and 5.24 and 2.42, respectively, for survivors at 2 to 5 years following treatment. The most common reported symptoms were related primarily to physical domains. No significant differences were found between the two survivor groups on the MSAS scores. Survivors at <2 years reported significantly higher scores in Psychological and Health Care System/Information needs (
p
< 0.01), and lower composite scores in physical and mental QoL (
p
< 0.05) than those at 2 to 5 years post-treatment. Significant direct and indirect effects were found of symptom burden through unmet needs on survivors’ physical and mental QoL after adjustment for survival time, and the models showed a good fit.
Conclusions
Results suggest that breast cancer survivors continue to endure many symptoms independent of the survivorship period. The unmet needs mediate the relationship between symptom burden and survivors’ QoL.
The series battery string or supercapacitor string automatic equalization system based on quasi-resonant switched-capacitor converter is presented in this paper. It realizes the zero-voltage gap ...between cells and allows maximum energy recovery in a series battery system or supercapacitor system. It not only inherits the advantage of conventional switched-capacitor battery cell balancing system, but also overcomes the drawback of conduction loss, switching loss, and finite voltage difference among battery cells. All switches are MOSFET and controlled by just a pair of complementary signals in synchronous trigger pattern and the resonant tanks operate alternatively between the two states of charging and discharging. Zero-current switching and zero-voltage gap are achieved in this paper. Different resonant tank designs can meet the needs of different balancing time to meet the needs of different energy storage devices. Experimental results indicate that the efficiency of the system is high exceeding 98%. The system is very suitable for balancing used in battery management system.
Battery monitoring is vital for most electric vehicles (EVs), because the safety, operation, and even the life of the passenger depends on the battery system. This attribute is exactly the major ...function of the battery-management system (BMS)-to check and control the status of battery within their specified safe operating conditions. In this paper, a typical BMS block diagram has been proposed using various functional blocks. The state of charge (SOC) estimation has been implemented using Coulomb counting and open-circuit voltage methods, thereby eliminating the limitation of the stand-alone Coulomb counting method. By modeling the battery with SOC as one of the state variables, SOC can be estimated, which is further corrected by the Kalman filtering method. The battery parameters from experimental results are integrated in the model, and simulation results are validated by experiment.
Highly sensitive and specific urine-based tests to detect either primary or recurrent bladder cancer have proved elusive to date. Our ever increasing knowledge of the genomic aberrations in bladder ...cancer should enable the development of such tests based on urinary DNA.
DNA was extracted from urine cell pellets and PCR used to amplify the regions of the TERT promoter and coding regions of FGFR3, PIK3CA, TP53, HRAS, KDM6A and RXRA which are frequently mutated in bladder cancer. The PCR products were barcoded, pooled and paired-end 2 x 250 bp sequencing performed on an Illumina MiSeq. Urinary DNA was analysed from 20 non-cancer controls, 120 primary bladder cancer patients (41 pTa, 40 pT1, 39 pT2+) and 91 bladder cancer patients post-TURBT (89 cancer-free).
Despite the small quantities of DNA extracted from some urine cell pellets, 96% of the samples yielded mean read depths >500. Analysing only previously reported point mutations, TERT mutations were found in 55% of patients with bladder cancer (independent of stage), FGFR3 mutations in 30% of patients with bladder cancer, PIK3CA in 14% and TP53 mutations in 12% of patients with bladder cancer. Overall, these previously reported bladder cancer mutations were detected in 86 out of 122 bladder cancer patients (70% sensitivity) and in only 3 out of 109 patients with no detectable bladder cancer (97% specificity).
This simple, cost-effective approach could be used for the non-invasive surveillance of patients with non-muscle-invasive bladder cancers harbouring these mutations. The method has a low DNA input requirement and can detect low levels of mutant DNA in a large excess of normal DNA. These genes represent a minimal biomarker panel to which extra markers could be added to develop a highly sensitive diagnostic test for bladder cancer.
This letter describes two improved 13-level inverters based on switched-capacitor. Compared with their original structure, which is published recently, one less high-voltage capacitor is required in ...the proposed inverters and the blocking voltage of their inverting half-bridge is reduced by half. In addition, the new inverters inherit various advantages of the original structure, such as a high boost factor of 6, self-balanced capacitor voltages, and reduced voltage ripples. Circuit description, operation principle, hybrid PWM modulation, and capacitor voltage ripples are analyzed and the feasibility of the proposed inverters is finally verified by experimental results.
The primary health-care system in China Li, Xi; Lu, Jiapeng; Hu, Shuang ...
The Lancet (British edition),
12/2017, Letnik:
390, Številka:
10112
Journal Article
Recenzirano
Odprti dostop
China has made remarkable progress in strengthening its primary health-care system. Nevertheless, the system still faces challenges in structural characteristics, incentives and policies, and quality ...of care, all of which diminish its preparedness to care for a fifth of the world's population, which is ageing and which has a growing prevalence of chronic non-communicable disease. These challenges include inadequate education and qualifications of its workforce, ageing and turnover of village doctors, fragmented health information technology systems, a paucity of digital data on everyday clinical practice, financial subsidies and incentives that do not encourage cost savings and good performance, insurance policies that hamper the efficiency of care delivery, an insufficient quality measurement and improvement system, and poor performance in the control of risk factors (such as hypertension and diabetes). As China deepens its health-care reform, it has the opportunity to build an integrated, cooperative primary health-care system, generating knowledge from practice that can support improvements, and bolstered by evidence-based performance indicators and incentives.
Two improved torque-sharing functions for implementing torque ripple minimization (TRM) control are presented in this paper. The proposed torque-sharing functions are dependent on the turn-on angle, ...overlap angle, and the expected torque. This study shows that for a given torque the turn-on angle and the overlap angle have significant effects upon speed range, maximum speed, copper loss, and efficiency. Hence, genetic algorithm is used to optimize the turn-on angle and the overlap angle at various expected torque demands operating under the proposed TRM control in order to maximize the speed range and minimize the copper loss. Furthermore, four torque-sharing functions are used to derive the optimized results. At the same time, a fast and accurate online approach to compute the optimal turn-on and overlap angles is proposed. Therefore, this paper provides a valuable method to improve the performances of switched reluctance motor drives operating under TRM control.
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