Osteoclastoma-like giant cell tumor of lung. A case of osteoclastoma-like giant cell tumor of the lung is reported. This is an unusual tumor too described in the heart, thyroid, skin, soft tissues ...and pancreas. AA. studied the tumor's structure and are of opinion that it concerns a primitive nonepithelial neoplasm of the lung.
Hexahedral meshes generated from polycube mapping often exhibit a low number of singularities but also poor‐quality elements located near the surface. It is thus necessary to improve the overall mesh ...quality, in terms of the minimum scaled Jacobian (MSJ) or average SJ (ASJ). Improving the quality may be obtained via global padding (or pillowing), which pushes the singularities inside by adding an extra layer of hexahedra on the entire domain boundary. Such a global padding operation suffers from a large increase of complexity, with unnecessary hexahedra added. In addition, the quality of elements near the boundary may decrease. We propose a novel optimization method which inserts sheets of hexahedra so as to perform selective padding, where it is most needed for improving the mesh quality. A sheet can pad part of the domain boundary, traverse the domain and form singularities. Our global formulation, based on solving a binary problem, enables us to control the balance between quality improvement, increase of complexity and number of singularities. We show in a series of experiments that our approach increases the MSJ value and preserves (or even improves) the ASJ, while adding fewer hexahedra than global padding.
Hexahedral meshes generated from polycube mapping often exhibit a low number of singularities but also poor‐quality elements located near the surface. It is thus necessary to improve the overall mesh quality, in terms of the minimum scaled Jacobian (MSJ) or average SJ (ASJ). Improving the quality may be obtained via global padding (or pillowing), which pushes the singularities inside by adding an extra layer of hexahedra on the entire domain boundary. Such a global padding operation suffers from a large increase of complexity, with unnecessary hexahedra added. In addition, the quality of elements near the boundary may decrease. We propose a novel optimization method which inserts sheets of hexahedra so as to perform selective padding, where it is most needed for improving the mesh quality.
Live yeast use in stallion feeding Rassu, S.P.G; Cannas, A; Enne, G. (Sassari Univ. (Italy). Dipartimento di Scienze Zootecniche) ...
Proceeding of the ASPA Congress - Recent Progress in Animal Production Science (Italy),
(1999), Letnik:
1
Conference Proceeding
The effects of diet supplementation with live yeasts (20 g/head d) on feed digestibility and sperm quality of stallions were evaluated. The results showed a slight positive effect, not statistically ...significant, on digestibility during the first month of administration. The effects on quantitative and qualitative traits of semen were more interesting; sperm was better in treated group during 2 months following the interruption of treatment: volume ml 47 +- 9 vs 34 +- 5, concentration 10*6)/ml 575 +- 806 vs 416 +- 39, live spermatozoa 83 +- 5 % vs 65 +- 29 % (P0.05)
Sono stati valutati gli effetti della somministrazione dei lieviti vivi (20 g/capo d) sia sulla digeribilita' degli alimenti, sia sulle caratteristiche spermatiche degli stalloni. I risultati ottenuti hanno evidenziato un lieve effetto positivo sulla digeribilita', statisticamente non significativo, limitatamente al primo mese di somministrazione. Piu' interessanti sono stati gli effetti sulle caratteristiche quanti-qualitative del materiale seminale, risultato migliore nel gruppo trattato nei 2 mesi successivi la sospensione della somministrazione: volume ml 47 +- 9 vs 34 +- 5, concentrazione 10*6)/ml 575 +- 806 vs 416 +- 39, spermatozoi vivi 83 +- 5 % vs 65 +- 29 % (P0,05)
Remnants of early films often have a story to tell.
As material artifacts, these film fragments are central to
cinema history, perhaps more than ever in our digital age of easy
copying and sharing. ...If a digital copy is previewed before
preservation or is shared with a researcher outside the purview of
a film archive, knowledge about how the artifact was collected,
circulated, and repurposed threatens to become obscured. When the
question of origin is overlooked, the story can be lost. Concerned
contributors in Provenance and Early Cinema challenge
scholars digging through film archives to ask, "How did these
moving images get here for me to see them?"
This volume, which features the conference proceedings from
Domitor, the International Society for the Study of Early Cinema,
2018, questions preservation, attribution, and patterns of reuse in
order to explore singular artifacts with long and circuitous
lives.
Alopecia areata (AA) is a highly prevalent autoimmune disease that attacks the hair follicle and leads to hair loss that can range from small patches to complete loss of scalp and body hair. Our ...previous linkage and genome‐wide association studies (GWAS) generated strong evidence for aetiological contributions from inherited genetic variants at different population frequencies, including both rare mutations and common polymorphisms. Additionally, we conducted gene expression (GE) studies on scalp biopsies of 96 patients and controls to establish signatures of active disease. In this study, we performed an integrative analysis on these two datasets to test the hypothesis that rare CNVs in patients with AA could be leveraged to identify drivers of disease in our AA GE signatures. We analysed copy number variants (CNVs) in a case‐control cohort of 673 patients with AA and 16 311 controls independent of the case‐control cohort of 96 research participants used in our GE study. Using an integrative computational analysis, we identified 14 genes whose expression levels were altered by CNVs in a consistent direction of effect, corresponding to gene expression changes in lesional skin of patients. Four of these genes were affected by CNVs in three or more unrelated patients with AA, including ATG4B and SMARCA2, which are involved in autophagy and chromatin remodelling, respectively. Our findings identified new classes of genes with potential contributions to AA pathogenesis.
It has been shown that different genes could be associated with distinctive clinical and radiological phenotypes of FTD. TARDBP gene has been described worldwide in few cases of FTD so its phenotype ...is still unclear. The objective is to study the clinical and radiological characteristics of TARDBP-related FTD. In the present study, we report clinical, neuropsychological and radiological features of five new Sardinian non-related cases of FTD carriers of the p.A382T TARDBP mutation. Furthermore, we reviewed non-related FTD cases with TARDBP mutations previously described in literature. The p.A382T missense mutation of TARDBP was present in the 21.7 % of familial cases of our FTD cohort (5/23) and in no one of the sporadic patients. 3 of 5 patients showed a temporal variant FTD and 4/5 a predominant temporal involvement at MRI. The review of the literature of FTD cases with TARDBP mutations showed that in 5 of 16 cases, the clinical phenotype was consistent with temporal variant of FTD or semantic dementia (31 %) and in 7 of 16 cases neuroimaging showed predominant temporal lobe involvement (43.7 %). Our study further supports the pathogenetic role of TARDBP mutations in pure FTD and in the full spectrum of FTD/ALS. The presence of a predominant temporal lobe involvement in a high percentage of FTD mutated patients with a peculiar clinical pattern could be useful in the differential diagnosis with other forms of dementia/FTD both sporadic and familial.
To evaluate the pulmonary transit time (PTT) and its derived parameters using cardiac magnetic resonance imaging (CMRI) as markers of diastolic dysfunction in Takotsubo syndrome (TS) and its ...relationship with transthoracic echocardiography and CMRI parameters.
Twenty-two patients with TS, who exhibited diastolic dysfunction as assessed by transthoracic echocardiography, were enrolled retrospectively and the PTT, pulmonary transit time index (PTTI), and pulmonary blood volume index (PBVI) were evaluated using first-pass CMRI. PTT was calculated as the number of cardiac cycles required for a bolus of contrast agent to move from the right ventricle (RV) to the left ventricle (LV), whereas PTTI represents the PTT interval corrected for the heart rate. Finally, PBVI was calculated as the product of PTTI, and RV stroke volume indexed for body surface area. Normal references of PTT, PTTI, and PBVI were evaluated in a cohort of 20 age- and sex-matched healthy controls.
Compared with healthy subjects, TS patients showed significantly higher PTT, PTTI, and PBVI (p=0.0001, p=0.0001, and p=0.002, respectively). Using multivariable logistic regression, PBVI provided the best differentiation between TS and controls (AUC 0.84). PBVI was significantly associated with the index of diastolic dysfunction and left atrial strain parameters. In addition, PBVI demonstrated a significant correlation with global T2 mapping (r=0,520, p=0,019).
PTT and the derived parameters, as assessed using first-pass CMRI, are potential tools for assessing LV diastolic dysfunction in patients with TS.
•PTT was suggested as a feasible CMR tool to assess diastolic dysfunction.•TS patients showed higher PTT, PTTI, and PBVI values in comparison with healthy controls.•PTT and its derived parameters may be new tools in evaluating the diastolic function in TS patients.
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