•Guaiacol; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or ...TTC.
•Benzyl butyrate; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, ...and/or TTC.
•Benzoic acid; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, ...and/or TTC.
•p-Methoxybenzaldehyde; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, ...read-across, and/or TTC.
•p-Mentha-1,8-dien-7-yl acetate; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, ...read-across, and/or TTC.
A pilot quality-of-life instrument for acne rosacea Nicholson, Kimberly, MD; Abramova, Liana, MD; Chren, Mary-Margaret, MD ...
Journal of the American Academy of Dermatology,
08/2007, Letnik:
57, Številka:
2
Journal Article
Recenzirano
Background No rosacea-specific quality-of-life (QOL) instrument exists. Objective We sought to develop a validated, reliable rosacea-specific instrument. Methods From 6 in-depth interviews, we ...composed 21 rosacea-specific items. These items and Skindex-29 were administered in a validation cohort (n = 59). Internal consistency reliability and reproducibility were measured with Cronbach's coefficient α and intraclass correlation coefficient, respectively. Responsiveness was assessed comparing baseline with 4- to 6-month responses. Construct validity was assessed with principal axes factor analyses. Discriminant validity was examined with an additional 38 patients comparing differences in responsiveness between the rosacea-specific QOL instrument and Skindex. Results Reliability was high (Cronbach's α: 0.82-0.97, intraclass correlation coefficient: 0.70-0.95). The rosacea-specific QOL instrument showed preliminary responsiveness for patients with improved disease ( P ≤ .05). Principal axes factor analyses correlated to hypothesized scales ( r = 0.57-0.82). Discriminant validity was illustrated with greater differences in responsiveness using the rosacea-specific QOL instrument ( P = .008). Limitations Potential selection bias and lack of generalizability was a limitation. Conclusions The rosacea-specific QOL instrument, RosaQoL, appears to be a reliable and valid QOL instrument and shows preliminary responsiveness for patients with improving rosacea.
•β-Sinensal; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, read-across, and/or ...TTC.
•Ethanol, 2-(4-methylphenoxy)-1-(2-phenylethoxy)-; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared ...using target data, read-across, and/or TTC.
•α-Methylbenzyl acetate; a safety assessment based on RIFM's criteria.•A safety assessment based on 7 human health endpoints plus environmental.•All endpoints were cleared using target data, ...read-across, and/or TTC.
