Objectives
Sarcopenia, defined as an age-associated loss of skeletal muscle function and muscle mass, occurs in approximately 6 - 22 % of older adults. This paper presents evidence-based clinical ...practice guidelines for screening, diagnosis and management of sarcopenia from the task force of the International Conference on Sarcopenia and Frailty Research (ICSFR).
Methods
To develop the guidelines, we drew upon the best available evidence from two systematic reviews paired with consensus statements by international working groups on sarcopenia. Eight topics were selected for the recommendations: (i) defining sarcopenia; (ii) screening and diagnosis; (iii) physical activity prescription; (iv) protein supplementation; (v) vitamin D supplementation; (vi) anabolic hormone prescription; (vii) medications under development; and (viii) research. The ICSFR task force evaluated the evidence behind each topic including the quality of evidence, the benefitharm balance of treatment, patient preferences/values, and cost-effectiveness. Recommendations were graded as either strong or conditional (weak) as per the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. Consensus was achieved via one face-to-face workshop and a modified Delphi process.
Recommendations
We make a conditional recommendation for the use of an internationally accepted measurement tool for the diagnosis of sarcopenia including the EWGSOP and FNIH definitions, and advocate for rapid screening using gait speed or the SARC-F. To treat sarcopenia, we strongly recommend the prescription of resistance-based physical activity, and conditionally recommend protein supplementation/a protein-rich diet. No recommendation is given for Vitamin D supplementation or for anabolic hormone prescription. There is a lack of robust evidence to assess the strength of other treatment options.
Managing mining of the deep seabed Wedding, L M; Reiter, S M; Smith, C R ...
Science (American Association for the Advancement of Science),
07/2015, Letnik:
349, Številka:
6244
Journal Article
Recenzirano
Odprti dostop
Contracts are being granted, but protections are lagging
Interest in mining the deep seabed is not new; however, recent technological advances and increasing global demand for metals and rare-earth ...elements may make it economically viable in the near future (
1
). Since 2001, the International Seabed Authority (ISA) has granted 26 contracts (18 in the last 4 years) to explore for minerals on the deep seabed, encompassing ∼1 million km
2
in the Pacific, Atlantic, and Indian Oceans in areas beyond national jurisdiction (
2
). However, as fragile habitat structures and extremely slow recovery rates leave diverse deep-sea communities vulnerable to physical disturbances such as those caused by mining (
3
), the current regulatory framework could be improved. We offer recommendations to support the application of a precautionary approach when the ISA meets later this July.
This study evaluated the effect of 4 weeks of low‐load resistance exercise with blood flow restriction (BFRE) on increasing strength in comparison with high‐load resistance exercise (HLE), and ...assessed changes in blood, vascular and neural function. Healthy adults performed leg extension BFRE or HLE 3 days/week at 30% and 80% of strength, respectively. During BFRE, a cuff on the upper leg was inflated to 30% above systolic blood pressure. Strength, pulse‐wave velocity (PWV), ankle‐brachial index (ABI), prothrombin time (PT) and nerve conduction (NC) were measured before and after training. Markers of coagulation (fibrinogen and D‐dimer), fibrinolysis tissue plasminogen activator (tPA) and inflammation high sensitivity C‐reactive protein (hsCRP) were measured in response to the first and last exercise bouts. Strength increased 8% with BFRE and 13% with HLE (P<0.01). No changes in PWV, ABI, PT or NC were observed following training for either group (P>0.05). tPA antigen increased 30–40% immediately following acute bouts of BFRE and HLE (P=0.01). No changes were observed in fibrinogen, D‐dimer or hsCRP (P>0.05). These findings indicate that both protocols increase the strength without altering nerve or vascular function, and that a single bout of both protocols increases fibrinolytic activity without altering selected markers of coagulation or inflammation in healthy individuals.
Aims. The DustPedia project is capitalising on the legacy of the Herschel Space Observatory, using cutting-edge modelling techniques to study dust in the 875 DustPedia galaxies – representing the ...vast majority of extended galaxies within 3000 km s-1 that were observed by Herschel. This work requires a database of multiwavelength imagery and photometry that greatly exceeds the scope (in terms of wavelength coverage and number of galaxies) of any previous local-Universe survey. Methods. We constructed a database containing our own custom Herschel reductions, along with standardised archival observations from GALEX, SDSS, DSS, 2MASS, WISE, Spitzer, and Planck. Using these data, we performed consistent aperture-matched photometry, which we combined with external supplementary photometry from IRAS and Planck. Results. We present our multiwavelength imagery and photometry across 42 UV-microwave bands for the 875 DustPedia galaxies. Our aperture-matched photometry, combined with the external supplementary photometry, represents a total of 21 857 photometric measurements. A typical DustPedia galaxy has multiwavelength photometry spanning 25 bands. We also present the Comprehensive & Adaptable Aperture Photometry Routine (CAAPR), the pipeline we developed to carry out our aperture-matched photometry. CAAPR is designed to produce consistent photometry for the enormous range of galaxy and observation types in our data. In particular, CAAPR is able to determine robust cross-compatible uncertainties, thanks to a novel method for reliably extrapolating the aperture noise for observations that cover a very limited amount of background. Our rich database of imagery and photometry is being made available to the community.
The pseudostratified epithelium of the mouse trachea and human airways contains a population of basal cells expressing Trp-63 (p63) and cytokeratins 5 (Krt5) and Krt14. Using a KRT5-CreERT² ...transgenic mouse line for lineage tracing, we show that basal cells generate differentiated cells during postnatal growth and in the adult during both steady state and epithelial repair. We have fractionated mouse basal cells by FACS and identified 627 genes preferentially expressed in a basal subpopulation vs. non-BCs. Analysis reveals potential mechanisms regulating basal cells and allows comparison with other epithelial stem cells. To study basal cell behaviors, we describe a simple in vitro clonal sphere-forming assay in which mouse basal cells self-renew and generate luminal cells, including differentiated ciliated cells, in the absence of stroma. The transcriptional profile identified 2 cell-surface markers, ITGA6 and NGFR, which can be used in combination to purify human lung basal cells by FACS. Like those from the mouse trachea, human airway basal cells both self-renew and generate luminal daughters in the sphere-forming assay.
Aims. The purpose of this work is the characterization of the radial distribution of dust, stars, gas, and star-formation rate (SFR) in a sub-sample of 18 face-on spiral galaxies extracted from the ...DustPedia sample. Methods. This study is performed by exploiting the multi-wavelength DustPedia database, from ultraviolet (UV) to sub-millimeter bands, in addition to molecular (12CO) and atomic (Hi) gas maps and metallicity abundance information available in the literature. We fitted the surface-brightness profiles of the tracers of dust and stars, the mass surface-density profiles of dust, stars, molecular gas, and total gas, and the SFR surface-density profiles with an exponential curve and derived their scale-lengths. We also developed a method to solve for the CO-to-H2 conversion factor (αCO) per galaxy by using dust- and gas-mass profiles. Results. Although each galaxy has its own peculiar behavior, we identified a common trend of the exponential scale-lengths versus wavelength. On average, the scale-lengths normalized to the B-band 25 mag/arcsec2 radius decrease from UV to 70 μm, from 0.4 to 0.2, and then increase back up to ~0.3 at 500 microns. The main result is that, on average, the dust-mass surface-density scale-length is about 1.8 times the stellar one derived from IRAC data and the 3.6 μm surface brightness, and close to that in the UV. We found a mild dependence of the scale-lengths on the Hubble stage T: the scale-lengths of the Herschel bands and the 3.6 μm scale-length tend to increase from earlier to later types, the scale-length at 70 μm tends to be smaller than that at longer sub-mm wavelength with ratios between longer sub-mm wavelengths and 70 μm that decrease with increasing T. The scale-length ratio of SFR and stars shows a weak increasing trend towards later types. Our αCO determinations are in the range (0.3−9) M⊙ pc-2 (K km s-1)-1, almost invariant by using a fixed dust-to-gas ratio mass (DGR) or a DGR depending on metallicity gradient.
Recent projections of climatic change have focused a great deal of scientific and public attention on patterns of carbon (C) cycling as well as its controls, particularly the factors that determine ...whether an ecosystem is a net source or sink of atmospheric carbon dioxide (CO₂). Net ecosystem production (NEP), a central concept in C-cycling research, has been used by scientists to represent two different concepts. We propose that NEP be restricted to just one of its two original definitions-the imbalance between gross primary production (GPP) and ecosystem respiration (ER). We further propose that a new term-net ecosystem carbon balance (NECB)-be applied to the net rate of C accumulation in (or loss from negative sign) ecosystems. Net ecosystem carbon balance differs from NEP when C fluxes other than C fixation and respiration occur, or when inorganic C enters or leaves in dissolved form. These fluxes include the leaching loss or lateral transfer of C from the ecosystem; the emission of volatile organic C, methane, and carbon monoxide; and the release of soot and CO₂ from fire. Carbon fluxes in addition to NEP are particularly important determinants of NECB over long time scales. However, even over short time scales, they are important in ecosystems such as streams, estuaries, wetlands, and cities. Recent technological advances have led to a diversity of approaches to the measurement of C fluxes at different temporal and spatial scales. These approaches frequently capture different components of NEP or NECB and can therefore be compared across scales only by carefully specifying the fluxes included in the measurements. By explicitly identifying the fluxes that comprise NECB and other components of the C cycle, such as net ecosystem exchange (NEE) and net biome production (NBP), we can provide a less ambiguous framework for understanding and communicating recent changes in the global C cycle.
This manuscript describes the energy and water components of a new community land surface model called the Joint UK Land Environment Simulator (JULES). This is developed from the Met Office Surface ...Exchange Scheme (MOSES). It can be used as a stand alone land surface model driven by observed forcing data, or coupled to an atmospheric global circulation model. The JULES model has been coupled to the Met Office Unified Model (UM) and as such provides a unique opportunity for the research community to contribute their research to improve both world-leading operational weather forecasting and climate change prediction systems. In addition JULES, and its forerunner MOSES, have been the basis for a number of very high-profile papers concerning the land-surface and climate over the last decade. JULES has a modular structure aligned to physical processes, providing the basis for a flexible modelling platform.
We present the properties of the first 250 μm blind sample of nearby galaxies (15 < D < 46 Mpc) containing 42 objects from the Herschel Astrophysical Terahertz Large Area Survey. Herschel's ...sensitivity probes the faint end of the dust luminosity function for the first time, spanning a range of stellar mass (7.4 < M
⋆ < 11.3 log10 M⊙), star formation activity (−11.8 < SSFR < −8.9 log10 yr−1), gas fraction (3–96 per cent), and colour (0.6 < FUV–K
S < 7.0 mag). The median cold dust temperature is 14.6 K, colder than in the Herschel Reference Survey (18.5 K) and Planck Early Release Compact Source Catalogue (17.7 K). The mean dust-to-stellar mass ratio in our sample is higher than these surveys by factors of 3.7 and 1.8, with a dust mass volume density of (3.7 ± 0.7) × 105 M⊙ Mpc−3. Counter-intuitively, we find that the more dust rich a galaxy, the lower its UV attenuation. Over half of our dust-selected sample are very blue in FUV–K
S colour, with irregular and/or highly flocculent morphology; these galaxies account for only 6 per cent of the sample's stellar mass but contain over 35 per cent of the dust mass. They are the most actively star-forming galaxies in the sample, with the highest gas fractions and lowest UV attenuation. They also appear to be in an early stage of converting their gas into stars, providing valuable insights into the chemical evolution of young galaxies.
Despite years of research and hundreds of reports on tumour markers in oncology, the number of markers that have emerged as clinically useful is pitifully small. Often initially reported studies of a ...marker show great promise, but subsequent studies on the same or related markers yield inconsistent conclusions or stand in direct contradiction to the promising results. It is imperative that we attempt to understand the reasons that multiple studies of the same marker lead to differing conclusions. A variety of methodological problems have been cited to explain these discrepancies. Unfortunately, many tumour marker studies have not been reported in a rigorous fashion, and published articles often lack sufficient information to allow adequate assessment of the quality of the study or the generalisability of the study results. The development of guidelines for the reporting of tumour marker studies was a major recommendation of the US National Cancer Institute and the European Organisation for Research and Treatment of Cancer (NCI-EORTC) First International Meeting on Cancer Diagnostics in 2000. Similar to the successful CONSORT initiative for randomised trials and the STARD statement for diagnostic studies, we suggest guidelines to provide relevant information about the study design, preplanned hypotheses, patient and specimen characteristics, assay methods, and statistical analysis methods. In addition, the guidelines suggest helpful presentations of data and important elements to include in discussions. The goal of these guidelines is to encourage transparent and complete reporting so that the relevant information will be available to others to help them to judge the usefulness of the data and understand the context in which the conclusions apply.
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