We explore the presence of zoonotic flaviviruses (West Nile virus (WNV) and Usutu virus (USUV)) neutralizing antibodies in rarely studied passerine bird species. We report, for the first time in ...Europe, WNV-specific antibodies in red avadavat and cetti’s warbler, and USUV in yellow-crowned bishop. The evidence of WNV and USUV circulating in resident and migratory species has implications for both animal and public health. Future outbreaks in avian reservoir hosts may occur and passerines should be considered as priority target species in flavivirus surveillance programmes.
•West Nile virus (WNV) and Usutu virus (USUV) are emerging vector-borne zoonotic arboviruses with broadening incidence and distribution.•The role of small passerine as WNV and USUV reservoir and potential amplifying hosts of infection is still unclear in Europe.•We confirm flavivirus’ exposure in 82 individuals from 8 bird species that come in frequent contact with humans.•We report, for the first time in Europe, WNV-specific antibodies in red avadavat and cetti’s warbler, and USUV in yellow-crowned bishop.•These outcomes stress the importance to include passerines in the routine surveillance programmes for zoonotic diseases.
ABSTRACT
The study of gamma-ray blazars is usually hindered due to the lack of information on their redshifts and on their low-energy photon fields. This information is key to understand the effect ...on the gamma-ray absorption due to either extragalactic background light and/or intrinsic absorption and emission processes. All this information has also an impact on the determination of the location of the emitting region within the relativistic jets. In this work, a new optical spectroscopic characterization is presented for three gamma-ray blazars: S4 0954+65, TXS 1515−273, and RX J0812.0+0237. For all the three targets, the redshift determination is successful, and for the first time in the case of TXS 1515−273 and RX J0812.0+0237. Their classification as BL Lac type is confirmed based on these new optical spectra. For S4 0954+65 (z = 0.3694 ± 0.0011), an estimation on the disc, broad-line region, and torus luminosities is performed based on the observed optical emission lines. The results from this study are compatible with the nature of S4 0954+65 as a transitional blazar. In the case of TXS 1515−273 (z = 0.1281 ± 0.0004), although its optical spectrum is dominated by the continuum emission from the jet, applying the pPXF technique, the stellar population can be unveiled and is compatible with an old and metallic population. It is also the case of RX J0812.0+0237 (z = 0.1721 ± 0.0002). Moreover, this work confirms that the optical spectrum from RX J0812.0+0237 is compatible with an extreme blazar classification.
Lymphaticovenous anastomosis (LVA) is a surgical treatment for lymphedema that requires identification and mapping of functional lymphatic channels. This technique was performed blindly for years ...because of the lack of suitable methods of study. Progress in imaging techniques and the introduction of Indocyanine green lymphography (ICG-L) represented a significant advancement in lymphedema management. Magnetic resonance lymphangiography (MRL) has also helped improve knowledge about lymphedema anatomy and pathophysiology. We now present our protocol based on both ICG-L and MRL for optimal LVA preoperative planning.
A prospective study between April 2010 and June 2015 was conducted in 82 patients (77 females, mean age 45.5 years) with stage I (9.8%), II (73.2%), and III (17.0%) lymphedema. All patients underwent lymphedema surgical treatment with LVA. Surgery was planned based on preoperative information from ICG- L and MRL.
We obtained a mean of 6.87 lymphatic locations per extremity from MRL and selected a mean of 4.04 for LVA. When MRL data coincided with ICG-L data, we found a functional lymphatic vessel in 96.9% of cases and performed LVA successfully in 91.4%.
ICG-L and MRL are noninvasive techniques that provide images of the lymphatic system with sufficient temporal and spatial resolution to depict functional lymphatic vessels. Such knowledge is essential for preoperative planning of LVA microsurgery. We present our protocol for the approach of surgical treatment of lymphedema. This protocol represents a step forward in unifying patient selection criteria and achieving safe, effective, and rational surgery.
West Nile virus (WNV) is an emerging vector-borne arbovirus with a zoonotic life-cycle whose main reservoir hosts are birds. In humans and horses, WNV infections rarely result in clinical disease but ...on occasions – depending on factors such as climatic conditions, insect communities and background immunity levels in local populations – they can lead to outbreaks that threaten public and animal health. We tested for the presence of WNV antibodies in 149 birds belonging to 32 different species. Samples were first tested using a bird-specific ELISA kit and then both positive and doubtful results were confirmed by neutralization tests using WNV and Usutu virus. WNV antibodies were confirmed in a resident Sylvia melanocephala juvenile, supporting the idea of local transmission of WNV in southern Spain in 2013. In addition, the serum from an adult blackbird (Turdus merula) showed neutralization of both WNV and Usutu virus. We discuss our results in light of the occurrence of WNV on horse farms in southern Spain in 2013.
ABSTRACT
The emission from the relativistic jets in blazars usually outshines their host galaxies, challenging the determination of their distances and the characterization of the stellar population. ...The situation becomes more favourable in the case of the extreme blazars (EHBLs), for which the bulk of the emission of the relativistic jets is emitted at higher energies, unveiling the optical emission from the host galaxy. The distance determination is fundamental for the study of the intrinsic characteristics of the blazars, especially to estimate the intrinsic gamma-ray spectra distorted due to the interaction with the extragalactic background light. In this work, we report on the properties of 2WHSP J073326.7+515354 host galaxy in the optical band, which is one of the few EHBLs detected at TeV energies. We present the first measurement of the distance of the source, z = 0.065 04 ± 0.000 02 (velocity dispersion $\sigma =237 \pm 9\, \mathrm{km s^{-1}}$). We also perform a detailed study of the stellar population of its host galaxy. We find that the mass-weighted mean stellar age is $11.72\pm 0.06\, \mathrm{Gyr}$ and the mean metallicity M/H = 0.159 ± 0.016. In addition, a morphological study of the host galaxy is also carried out. The surface brightness distribution is modelled by a composition of a dominant classical bulge (Re = 3.77 ± 1 arcsec or equivalently 4.74 kpc) plus an unresolved source which corresponds to the active nucleus. The black hole mass is estimated using both the mass relation with the velocity dispersion and the absolute magnitude from the bulge yielding comparable results: $(4.8\pm 0.9)\times 10^8$ and $(3.7\pm 1.0)\times 10^8\, \mathrm{ M}_{\odot }$, respectively.
An accurate preoperative evaluation of the vascular anatomy of the abdominal wall is extremely valuable in improving the surgical strategy in abdominal perforator flaps. The multidetector-row ...computer tomography offers thin slice coverage of extended volumes with an extremely high spatial resolution. From October 2003 to December 2004, 66 female patients had breast reconstruction surgery in our department using the deep inferior epigastric artery perforator flap. Our multidetector-row computer tomography studies were performed using a 16-detector-row computer tomography scanner. The image assessment was carried out using the following protocol: we first identified the best three perforators from each side of the abdomen. Then we conducted a three-dimensional reconstruction of the abdomen by identifying exactly where the three best perforators emerged from the rectus abdominis fascia. We then transferred the data obtained from the image to the patient using a coordinate system. In addition, we also placed the dominant perforators in the patient by using a conventional hand-held Doppler. During the operation we compared intra-operative findings, Doppler results and computer tomography outcomes. Neither false positive nor false negative results were found in the computer tomography outcome. Multidetector-row computer tomography provides us with an easy method of interpreting the virtual anatomic dissection in three dimensions. It has high sensitivity and specificity and provides a good quality evaluation of the perforator vessels. This information allows reduction of operating time and safer performance of surgery. The multidetector-row computer tomography is a highly effective tool in the preoperative study of abdominal perforator flaps.
OBJECTIVE: XXXto assess the effect on cognition of a controlled intervention testing Mediterranean diets (MedDiet). DESIGN: XXXrandomized trial after 6.5 years of nutritional intervention. SETTING: ...Eight primary care centers affiliated to the University of Navarra. PARTICIPANTS: A random subsample of 285 participants (95 randomly allocated to each of 3 groups) of the PREDIMED-NAVARRA trial. All of them were at high vascular risk (44.8% men, 74.1± 5.7 years at cognitive evaluation). INTERVENTIONS: Nutritional intervention comparing two MedDiets (supplemented with extra-virgin olive oil EVOO or mixed nuts) versus a low-fat control diet. Participants received intensive education to increase adherence to the intended intervention. Participants allocated to the MedDiet groups received EVOO (1 l/week) or 30 g/day of mixed nuts. Dietary habits were evaluated using a validated 137-item food frequency questionnaire (FFQ). Additionally, adherence to MedDiet was appraised using a 14-item questionnaire both at baseline and yearly thereafter. MEASUREMENTS: XXXcognitive performance as a main outcome and cognitive status (normal, mild cognitive impairment MCI or dementia) as a secondary outcome were evaluated by two neurologists blinded to group assignment after 6.5 years of nutritional intervention. RESULTS: Better post-trial cognitive performance versus control in all cognitive domains and significantly better performance across fluency and memory tasks were observed for participants allocated to the MedDiet+EVOO group. After adjustment for sex, age, education, apolipoprotein E genotype, family history of cognitive impairment/dementia, smoking, physical activity, body mass index, hypertension, dyslipidaemia, diabetes, alcohol and total energy intake, this group also showed lower MCI (OR=0.34 95% CI: 0.12–0.97) compared with control group. Participants assigned to MedDiet+Nuts group did not differ from controls. CONCLUSION: A long-term intervention with an EVOO-rich MedDiet resulted in a better cognitive function in comparison with a control diet. However, non-significant differences were found for most cognitive domains. Participants allocated to an EVOO-rich MedDiet had less MCI than controls.
Anatomy of the Temporomandibular Joint Alomar, X., MD; Medrano, J., MD; Cabratosa, J., MD ...
Seminars in ultrasound, CT, and MRI,
06/2007, Letnik:
28, Številka:
3
Journal Article
Recenzirano
The temporomandibular joint (TMJ), also known as the mandibular joint, is an ellipsoid variety of the right and left synovial joints forming a bicondylar articulation. The common features of the ...synovial joints exhibited by this joint include a fibrous capsule, a disk, synovial membrane, fluid, and tough adjacent ligaments. Not only is the mandible a single bone but the cranium is also mechanically a single stable component; therefore, the correct terminology for the joint is the craniomandibular articulation. The term temporomandibular joint is misleading and seems to only refer to one side when referring to joint function. Magnetic resonance imaging has been shown to accurately delineate the structures of the TMJ and is the best technique to correlate and compare the TMJ components such as bone, disk, fluid, capsule, and ligaments with autopsy specimens.
A scaling study of excess OFF-state current in planar InGaAs quantum-well MOSFETs is reported. We find that pure band-to-band tunneling (BTBT) dominates the drain OFF-state current in deviceswith ...channel length above <inline-formula> <tex-math notation="LaTeX">\sim 1~\mu \text{m} </tex-math></inline-formula>. In this regime, the drain-gate voltage sets the rate of BTBT. In devices with channel lengths below <inline-formula> <tex-math notation="LaTeX">\textsf {1}~\mu \text{m} </tex-math></inline-formula>, a parasitic bipolar transistor effect becomes relevant. The bipolar current gain is found to scale inversely with the effective channel length for Lg between 70 nm and <inline-formula> <tex-math notation="LaTeX">\textsf {1}~\mu \text{m} </tex-math></inline-formula>, as expected from simple bipolar transistor theory. For Lg below ~7 nm, the OFF-state current increases rapidly due to an enhancement in bipolar current gain as a result of strong short-channel effects and punchthrough. Current gains in excess of 104 have been observed. A reduction in channel thickness decreases both BTBT and the bipolar gain effect.
West Nile virus (WNV) is a re-emerging flavivirus, primarily circulating among avian hosts and mosquito vectors, causing periodic outbreaks in humans and horses, often leading to neuroinvasive ...disease and mortality. Spain has reported several outbreaks, most notably in 2020 with seventy-seven human cases and eight fatalities. WNV has been serologically detected in horses in the Community of Madrid, but to our knowledge, it has never been reported from wild birds in this region. To estimate the seroprevalence of WNV in wild birds and horses in the Community of Madrid, 159 wild birds at a wildlife rescue center and 25 privately owned equines were sampled. Serum from thirteen birds (8.2%) and one equine (4.0%) tested positive with a WNV competitive enzyme-linked immunosorbent assay (cELISA) designed for WNV antibody detection but sensitive to cross-reacting antibodies to other flaviviruses. Virus-neutralization test (VNT) confirmed WNV antibodies in four bird samples (2.5%), and antibodies to undetermined flavivirus in four additional samples. One equine sample (4.0%) tested positive for WNV by VNT, although this horse previously resided in a WN-endemic area. ELISA-positive birds included both migratory and resident species, juveniles and adults. Two seropositive juvenile birds suggest local flavivirus transmission within the Community of Madrid, while WNV seropositive adult birds may have been infected outside Madrid. The potential circulation of flaviviruses, including WNV, in birds in the Madrid Community raises concerns, although further surveillance of mosquitoes, wild birds, and horses in Madrid is necessary to establish the extent of transmission and the principal species involved.
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