Abstract
The Canadian Hydrogen Intensity Mapping Experiment (CHIME) is a drift scan radio telescope operating across the 400–800 MHz band. CHIME is located at the Dominion Radio Astrophysical ...Observatory near Penticton, BC, Canada. The instrument is designed to map neutral hydrogen over the redshift range 0.8–2.5 to constrain the expansion history of the universe. This goal drives the design features of the instrument. CHIME consists of four parallel cylindrical reflectors, oriented north–south, each 100 m × 20 m and outfitted with a 256-element dual-polarization linear feed array. CHIME observes a two-degree-wide stripe covering the entire meridian at any given moment, observing three-quarters of the sky every day owing to Earth’s rotation. An FX correlator utilizes field-programmable gate arrays and graphics processing units to digitize and correlate the signals, with different correlation products generated for cosmological, fast radio burst, pulsar, very long baseline interferometry, and 21 cm absorber back ends. For the cosmology back end, the
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correlation matrix is formed for 1024 frequency channels across the band every 31 ms. A data receiver system applies calibration and flagging and, for our primary cosmological data product, stacks redundant baselines and integrates for 10 s. We present an overview of the instrument, its performance metrics based on the first 3 yr of science data, and we describe the current progress in characterizing CHIME’s primary beam response. We also present maps of the sky derived from CHIME data; we are using versions of these maps for a cosmological stacking analysis, as well as for investigation of Galactic foregrounds.
Abstract
We present a beam pattern measurement of the Canadian Hydrogen Intensity Mapping Experiment (CHIME) made using the Sun as a calibration source. As CHIME is a pure drift-scan instrument, we ...rely on the seasonal north–south motion of the Sun to probe the beam at different elevations. This semiannual range in elevation, combined with the radio brightness of the Sun, enables a beam measurement that spans ∼7200 square degrees on the sky without the need to move the telescope. We take advantage of observations made near solar minimum to minimize the impact of solar variability, which is observed to be <10% in intensity over the observation period. The resulting data set is highly complementary to other CHIME beam measurements—both in terms of angular coverage and systematics—and plays an important role in the ongoing program to characterize the CHIME primary beam.
Abstract LiteBIRD is a satellite mission to be launched by JAXA in the early 2030s. It will measure the Cosmic Microwave Background (CMB) primordial B-modes with an unprecedented sensitivity. ...Microwave radiation will be detected by Transition Edge Sensors (TESs) arrays multiplexed in frequency domain and read by Superconducting QUantum Interference Devices (SQUIDs). The LiteBIRD SQUID Controller Unit (SCU), based on the heritage of the successful design used for the ground-based SPT3G experiment, presents some novel elements that make it suitable for a space-borne application. We compare our first breadboard model with the ground-based, Off-The-Shelf Components (COTS) version, by driving the same SQUID Array Amplifier (SAA) at 4 K, measuring relevant quantities such as noise, gain and bandwidth. We demonstrate that the noise added by our first prototype (including a switching part for redundancy purposes) never exceeds the noise added by the COTS-based electronics board, representing our benchmark. We also present the first noise estimates with the SAA cooled below 1 K, going closer to the conditions expected for LiteBIRD operation.
Human influenza viruses cause acute respiratory symptoms that can lead to death. Due to the emergence of antiviral drug‐resistant strains, there is an urgent requirement for novel antiviral agents ...and innovative therapeutic strategies. Using the peptidomimetic ketobenzothiazole protease inhibitor RQAR‐Kbt (IN‐1, aka N‐0100) as a starting point, we report how substituting P2 and P4 positions with natural and unnatural amino acids can modulate the inhibition potency toward matriptase, a prototypical type II transmembrane serine protease (TTSP) that acts as a priming protease for influenza viruses. We also introduced modifications of the peptidomimetics N‐terminal groups, leading to significant improvements (from μM to nM, 60 times more potent than IN‐1) in their ability to inhibit the replication of influenza H1N1 virus in the Calu‐3 cell line derived from human lungs. The selectivity towards other proteases has been evaluated and explained using molecular modeling with a crystal structure recently obtained by our group. By targeting host cell TTSPs as a therapeutic approach, it may be possible to overcome the high mutational rate of influenza viruses and consequently prevent potential drug resistance.
Modifications (highlighted in red) to the type II transmembrane serine protease (TTSP) peptidomimetic inhibitor RQAR‐Kbt (IN‐1, N‐0100) significantly improve the efficacy in blocking multicycle replication of Influenza H1N1 virus in human lung cells. This innovative strategy targets host cell enzymes, addressing the challenge of rapid influenza mutations and potential drug resistance.
To compare functional autonomy, quality of life (QOL), and pain control after endovascular and open repair (OR) of abdominal aortic aneurysms.
Forty patients with a low surgical risk profile and ...anatomic compatibility for stent-graft therapy were randomized to receive OR or endovascular aneurysm repair (EVAR). Technical and clinical success as well as mortality were assessed in both groups and compared by Kaplan-Meier analysis. Functional autonomy and QOL were assessed by Karnofsky score and Short Form 36 (SF-36) questionnaire. Pain control was assessed by a numeric rating scale and Brief Pain Inventory questionnaire. QOL outcomes by means of the SF-36 and pain questionnaires were compared with use of mixed-effects models for repeated-measures analysis.
All procedures were technically successful in both groups. Three late clinical failures requiring surgical conversion or repeated intervention were observed in the EVAR group and one was observed in the OR group. There was no significant difference between groups in terms of functional autonomy or QOL. No difference in pain level was evident during the early postoperative period, whereas the pain level was lower in the OR group after 1 month. Opioid analgesic drug consumption was significantly greater in the OR group during the postoperative period. Mean hospitalization duration was shorter in the EVAR group than in the OR group (4.5 days +/- 2.4 vs 11.5 days +/- 8.1; P= .001).
EVAR has no advantage over OR in patients at low risk in terms of functional autonomy, QOL, and pain control. However, EVAR was associated with shorter hospitalization durations compared with OR.
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