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zadetkov: 377
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  • SQ109 Targets MmpL3, a Memb... SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis
    Tahlan, Kapil; Wilson, Regina; Kastrinsky, David B ... Antimicrobial Agents and Chemotherapy, 04/2012, Letnik: 56, Številka: 4
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    SQ109, a 1,2-diamine related to ethambutol, is currently in clinical trials for the treatment of tuberculosis, but its mode of action remains unclear. Here, we demonstrate that SQ109 disrupts cell ...
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32.
  • Trastuzumab Increases HER2 ... Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells
    Gall, Victor A; Philips, Anne V; Qiao, Na ... Cancer research, 10/2017, Letnik: 77, Številka: 19
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    Early-phase clinical trials evaluating CD8 T cell-eliciting, HER2-derived peptide vaccines administered to HER2 breast cancer patients in the adjuvant setting suggest synergy between the vaccines and ...
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33.
  • Prospective, randomized, si... Prospective, randomized, single-blinded, multi-center phase II trial of two HER2 peptide vaccines, GP2 and AE37, in breast cancer patients to prevent recurrence
    Brown, Tommy A.; Mittendorf, Elizabeth A.; Hale, Diane F. ... Breast cancer research and treatment, 06/2020, Letnik: 181, Številka: 2
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    Purpose AE37 and GP2 are HER2 derived peptide vaccines. AE37 primarily elicits a CD4+ response while GP2 elicits a CD8+ response against the HER2 antigen. These peptides were tested in a large ...
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34.
  • Association between BRAF V6... Association between BRAF V600E mutation and recurrence of papillary thyroid cancer
    Xing, Mingzhao; Alzahrani, Ali S; Carson, Kathryn A ... Journal of clinical oncology, 01/2015, Letnik: 33, Številka: 1
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    To investigate the prognostic value of BRAF V600E mutation for the recurrence of papillary thyroid cancer (PTC). This was a retrospective multicenter study of the relationship between BRAF V600E ...
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35.
  • Differential Regulation of ... Differential Regulation of KiSS-1 mRNA Expression by Sex Steroids in the Brain of the Male Mouse
    Smith, Jeremy T; Dungan, Heather M; Stoll, Elizabeth A ... Endocrinology, 07/2005, Letnik: 146, Številka: 7
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    Kisspeptins are products of the Kiss1 gene, which bind to GPR54, a G protein-coupled receptor. Kisspeptins and GPR54 have been implicated in the neuroendocrine regulation of GnRH secretion. To test ...
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36.
  • Discovery of a Cyclic Boron... Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases
    Hecker, Scott J; Reddy, K Raja; Totrov, Maxim ... Journal of medicinal chemistry, 05/2015, Letnik: 58, Številka: 9
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    The increasing dissemination of carbapenemases in Gram-negative bacteria has threatened the clinical usefulness of the β-lactam class of antimicrobials. A program was initiated to discover a new ...
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38.
  • Meropenem inhibits D,D-carb... Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis
    Kumar, Pradeep; Arora, Kriti; Lloyd, John R. ... Molecular microbiology, October 2012, Letnik: 86, Številka: 2
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    Summary Carbapenems such as meropenem are being investigated for their potential therapeutic utility against highly drug‐resistant tuberculosis. These β‐lactams target the transpeptidases that ...
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40.
  • Very early hypothermia indu... Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial
    Clifton, Guy L, Prof; Valadka, Alex, MD; Zygun, David, MD ... Lancet neurology, 02/2011, Letnik: 10, Številka: 2
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    Summary Background The inconsistent effect of hypothermia treatment on severe brain injury in previous trials might be because hypothermia was induced too late after injury. We aimed to assess ...
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