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zadetkov: 560
1.
  • Physiology and pathophysiol... Physiology and pathophysiology of iron in hemoglobin-associated diseases
    Coates, Thomas D. Free radical biology & medicine, 07/2014, Letnik: 72
    Journal Article
    Recenzirano
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    Iron overload and iron toxicity, whether because of increased absorption or iron loading from repeated transfusions, can be major causes of morbidity and mortality in a number of chronic anemias. ...
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  • Iron overload in transfusio... Iron overload in transfusion-dependent patients
    Coates, Thomas D Hematology, 12/2019, Letnik: 2019, Številka: 1
    Journal Article
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    Before the advent of effective iron chelation, death from iron-induced cardiomyopathy occurred in the second decade in patients with transfusion-dependent chronic anemias. The advances in our ...
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4.
  • Iron and oxidative stress i... Iron and oxidative stress in cardiomyopathy in thalassemia
    Berdoukas, Vasilios; Coates, Thomas D.; Cabantchik, Zvi Ioav Free radical biology & medicine, 11/2015, Letnik: 88, Številka: Pt A
    Journal Article
    Recenzirano

    With repeated blood transfusions, patients with thalassemia major rapidly become loaded with iron, often surpassing hepatic metal accumulation capacity within ferritin shells and infiltrating heart ...
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5.
  • How we manage iron overload... How we manage iron overload in sickle cell patients
    Coates, Thomas D.; Wood, John C. British journal of haematology, June 2017, Letnik: 177, Številka: 5
    Journal Article
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    Summary Blood transfusion plays a prominent role in the management of patients with sickle cell disease (SCD), but causes significant iron overload. As transfusions are used to treat the severe ...
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  • Splenic iron decreases without change in volume or liver parameters during luspatercept therapy
    Denton, Christopher C; Vodala, Sadanand; Veluswamy, Saranya ... Blood, 11/2023, Letnik: 142, Številka: 22
    Journal Article
    Recenzirano

    Splenic iron decreased whereas liver iron was stable during luspatercept therapy in some individuals with thalassemia. This suggests a reduction of ineffective erythropoiesis changes the organ ...
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  • Diminished cerebral oxygen ... Diminished cerebral oxygen extraction and metabolic rate in sickle cell disease using T2 relaxation under spin tagging MRI
    Bush, Adam M.; Coates, Thomas D.; Wood, John C. Magnetic resonance in medicine, July 2018, Letnik: 80, Številka: 1
    Journal Article
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    Purpose T2 MRI oximetry can noninvasively determine oxygen saturation (Y) but requires empirical MR calibration models to convert the measured blood transverse relaxation (T2b) into Y. The accuracy ...
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9.
  • MRI R2 and R2 mapping accur... MRI R2 and R2 mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients
    Wood, John C.; Enriquez, Cathleen; Ghugre, Nilesh ... Blood, 08/2005, Letnik: 106, Številka: 4
    Journal Article
    Recenzirano
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    Measurements of hepatic iron concentration (HIC) are important predictors of transfusional iron burden and long-term outcome in patients with transfusion-dependent anemias. The goal of this work was ...
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