Purpose
The aim of this study was to examine the association between eHealth literacy and health-related quality of life (HRQoL) and explore whether health-promoting behaviors mediate the association ...between eHealth literacy and HRQoL among Chinese older adults.
Methods
An anonymous cross-sectional survey was conducted among 2300 adults aged 60 or older from Jinan, China. The eHealth Literacy Scale, Short-Form Health-Promoting Lifestyle Profile, and Short-Form Health Survey (SF-12) were used to measure eHealth literacy, health-promoting behaviors, and HRQoL. Multivariate linear regression analyses were conducted to test the association between eHealth literacy, health-promoting behaviors, and HRQoL. The mediation analyses, composed of PROCESS analysis and bootstrapping method, were preformed to test both total (
c
), direct (
c'
), and indirect effects (
a*b
) of eHealth literacy on HRQOL through health-promoting behaviors.
Results
Regression analyses indicated that eHealth literacy (
B
= 0.487,
p
< 0.001) was significantly positively associated with health-promoting behaviors, and health-promoting behaviors (
B
= 0.257,
p
< 0.001) were associated with HRQoL. The mediation analyses indicated that eHealth literacy had a significant direct (
c'
= 0.183,
p
< 0.001) and indirect effect on older adults’ HRQoL through health-promoting behaviors (
a*b
= 0.125, bootstrapped 95% confidence interval (
CI
) = 0.094–0.157). The indirect effect accounted for 40.6% of the total effect (
c
= 0.308, bootstrapped 95% CI 0.241–0.376) of eHealth literacy on HRQoL.
Conclusions
Health-promoting behaviors mediated the association between eHealth literacy and HRQoL in Chinese older adults. The establishment of interventions focused on health-promoting behavior may be an effective way to help older adults with low eHealth literacy improve their HRQoL.
Abstract
Background
Cross-sectional and longitudinal studies have found that problematic mobile phone use, bedtime procrastination, sleep quality, and depressive symptoms are strongly associated. ...However, studies are inconsistent regarding whether problematic mobile phone use predicts depressive symptoms or vice versa, and sleep factors have been infrequently focused on in this regard. In addition, few studies have examined the longitudinal associations and directions of effects between these factors. Therefore, this study aims to explore the longitudinal relationship among problematic mobile phone use, bedtime procrastination, sleep quality, and depressive symptoms in college students.
Methods
Overall, 1181 college students completed questionnaires on problematic mobile phone use, bedtime procrastination, sleep quality, and depressive symptoms at two time points 12 months apart. A cross-lagged model was used to examine the longitudinal relationship between these factors.
Results
Cross-lagged analyses showed significant bidirectional relationships of problematic mobile phone use with bedtime procrastination and depressive symptoms. Additionally, there were also significant bidirectional relationships of sleep quality with bedtime procrastination and depressive symptoms. Problematic mobile phone use predicted subsequent sleep quality one-way, and bedtime procrastination predicted subsequent depressive symptoms one-way.
Conclusions
This study further expands our understanding of the longitudinal and bidirectional relationships among problematic mobile phone use, bedtime procrastination, sleep quality and depressive symptoms and helps school mental health educators design targeted interventions to reduce problematic mobile phone use, sleep problems, and depressive symptoms among college students.
In examining the historical changes in cognitive psychology from 1895 to 1949, it is necessary to transform cognitive psychology into cognitive practice. In the late Qing and early Republic era ...(1895-1919), cognitive practice mainly appeared as the cognition of the sick at heart. Against the background of the late Qing importation of Western learning aimed at securing national salvation, the intellectual class, represented by Tan Sitong, hastily dressed the wound to the traditional Chinese learning of Heaven and man inflicted by late nineteenth century scientific knowledge from Europe and America. They regarded cognition as the understanding gained in the practice of self-cultivation, as affording man a spiritual resting place between Heaven and Earth. By the time of the Republic of China (1920-1949), the main form of cognitive practice had become ghostly cognition. Under the banner of saving the country by means of science, higher education researchers, represented by Lu Zhiwei, explored cognition with the help of such intermediaries as physiological mechanisms and language structure. Men could easily become ghosts trapped in intermediaries when they plunged into the conceptual world in search of truth, as their cognitive practice evolved into the conceptual grasp of ghosts. This ghostly cognition continued into later information processing psychology and was disseminated among the mass of the public. A deeper level of the cognition of the sick at heart remains for future study, on the lengthy road home.
Inflammatory bowel disease (IBD) and atherosclerosis (AS) are both common chronic inflammatory diseases with similar pathophysiological mechanisms. Some studies have shown that IBD patients are at ...increased risk for early atherosclerosis, myocardial infarction and venous thrombosis. Here we set up a hybrid mouse model associated with atherosclerosis and acute colitis in order to investigate the interplay of the two diseases. We fed ApoE-/- mice with high fat diet to establish atherosclerosis model, and used animal ultrasound machine to detect the artery of mice noninvasively. Then a new hybrid model of atherosclerosis and acute colitis was prepared by drinking water for 7 days. At the end of the experiment, the hybrid model mice showed typically pathological and intuitionistic changes of atherosclerosis and acute colitis. We found the shortened colon length, high histopathological scores of the colon with mucosal erosion and necrosis, hyperlipidemia, a plaque-covered mouse aorta and plaque with foam cells and lipid deposition in the hybrid model group, which proved that the hybrid model was successfully established. At the same time, ultrasonic detection showed that the end-diastolic blood flow velocity and the relative dilation value were decreased, while systolic time / diastolic time, the wall thickness, systolic diameters as well as diastolic diameters were gradually increased, and statistical significance appeared as early as 8 weeks. We clearly described the process of establishing a hybrid model of atherosclerosis and acute colitis, which might provide a repeatable platform for the interaction mechanism exploring and drug screening of atherosclerosis and inflammatory bowel disease in preclinical study.
Background
Several studies have shown that neurodegenerative diseases (e.g., Parkinson’s disease PD and Alzheimer’s disease AD) are associated with inflammatory bowel disease (IBD), but the causality ...and direction of their associations remain unclear. Mendelian randomization (MR) studies have explored the causal effects of IBD on PD and AD. However, only a few studies examined this reverse association. Thus, this study aimed to explore whether there are causal associations of genetically predicted PD and AD with IBD, using a two-sample MR study.
Methods
Summary statistics for IBD, ulcerative colitis (UC), and Crohn’s disease (CD) were derived from a genome-wide association study (GWAS) meta-analysis, which included the International IBD Genetics Consortium and the UK IBD Genetics Consortium (n=59,957). Genetic variants associated with the largest meta-analysis of GWAS of PD (n=1,474,097) and AD (n=455,258) were used as instrumental variables. We used multiple methods, including inverse variance weighted (IVW), weighted median (WM), MR-Egger regression, weighted mode, and Robust Adjusted Profile Score (RAPS) methods, to estimate the effects of genetically predicted PD and AD on IBD. To confirm the validity of the analysis, we also evaluated the pleiotropic effects, heterogeneity, and leave-one-out sensitivity analysis that drive causal associations.
Results
The results of the IVW method, WM, and RAPS showed that genetically predicted PD was significantly associated with an increased risk of UC (odds ratio
OR
IVW
=1.068,
OR
WM
=1.107,
OR
RAPS
=1.069, all
P
<0.05). Additionally, we found that there were significant associations of genetically predicted PD with CD (
OR
IVW
=1.064,
OR
RAPS
=1.065, all
P
<0.05) and IBD (
OR
IVW
=1.062,
OR
RAPS
=1.063, all
P
<0.05) using the IVW method and RAPS. However, there was no significant causal evidence of genetically predicted AD in IBD, UC, or CD among all MR methods. In all MR analyses, there were no horizontal pleiotropy (all
P
>0.05), or statistical heterogeneity. The sensitivity analysis results of the leave-one-out sensitivity analysis showed that the causal effect estimations of genetically predicted PD and AD on IBD were robust.
Conclusions
Our MR study corroborated a causal association between genetically predicted PD and IBD but did not support a causal effect of genetically predicted AD on IBD. More animal experiments or population-based observational studies are required to clarify the underlying mechanisms of PD and IBD.
Purpose
This study aimed to examine the psychometric properties of the Chinese version of the modified Yale Food Addiction Scale 2.0 (C-mYFAS 2.0) and to analyze the prevalence of food addiction ...among Chinese college students and its relationship with resilience and social support.
Methods
A total of 1132 Chinese college students completed the C-mYFAS 2.0, BES, EAT-26, PHQ-9, GAD-7, TFEQ-18, CD-RISC-10, and PSSS. Confirmatory factor analysis was used to evaluate the factor structure of the C-mYFAS 2.0 and psychometric properties were assessed. Test–retest reliability was evaluated in a sub-sample (
n
= 62). Spearman correlation and logistic regression were used to examine the relationship between resilience, social support, and food addiction.
Results
The prevalence of food addiction according to the C-mYFAS 2.0 was 6.2%. Confirmatory factor analyses suggested a single-factor structure (comparative fit index = 0.961). The C-mYFAS 2.0 had good test–retest reliability and internal consistency (Kuder–Richardson’s α = 0.824). Good convergent validity was indicated by correlations with binge eating, eating disorder symptoms, depressive symptoms, generalized anxiety symptoms, uncontrolled eating, emotional eating, and BMI (
p
s < 0.001). Appropriate divergent validity was reflected by no association with cognitive restraint. Finally, binge eating was significantly predicted by C-mYFAS 2.0, depressive symptoms, and eating disorder symptoms (
p
s < 0.001), confirming incremental validity. In addition, our study found that poorer resilience and social support were related to food addiction (
p
s < .001).
Conclusions
The C-mYFAS 2.0 is a brief but reliable and valid screening instrument for food addiction among Chinese college students. In addition, we found that resilience and social support were negatively associated with food addiction.
Level of Evidence: Level V, cross-sectional descriptive study.
Objective
Digital divide in health-related technology use is a prominent issue for older adults. Improving eHealth literacy may be an important solution to this problem. This study aimed to explore ...the associations between health literacy, digital skills, and eHealth literacy among older Chinese adults.
Methods
A total of 2,144 older adults (mean age, 72.01 ± 6.96 years) from Jinan City, China participated in this study. The eHealth Literacy Scale was used to measure eHealth literacy in older adults. A linear regression model was used to analyze the associations among health literacy, digital skills, and eHealth literacy in older Chinese adults.
Results
The mean eHealth literacy score of the older adults was 17.56 ± 9.61. After adjusting for sociodemographic characteristics and experience of Internet usage, the results of the linear regression showed that health literacy (B = 0.258, 95% confidence interval (CI) = 0.215–0.302, P< 0.001) and digital skills (B = 0.654, 95% CI = 0.587–0.720, P < 0.001) were positively associated with eHealth literacy. Sensitivity analyses revealed that this association remained robust.
Conclusions
The level of eHealth literacy in older Chinese adults is low. Health literacy and digital skills are associated with eHealth literacy in older adults. In the future, eHealth literacy intervention research should be considered from the perspective of health literacy and digital skills.
Obstructive sleep apnea-hypopnea (OSAH) is correlated with an increased incidence of lung cancer. In our study, we explored the functional roles of microRNAs (miRNAs) in lung cancer patients that ...were complicated with OSAH involving the deubiquitination enzyme. The miR-320b expression pattern in lung cancer tissues and cells was determined. The interactions between ubiquitin-specific peptidase 37 (USP37) and miR-320b were evaluated by a dual-luciferase reporter gene assay, whereas USP37 and Cdc10-dependent transcript 1 (CDT1) was assessed by co-immunoprecipitation and immunofluorescence. After the induction of intermittent hypoxia (IH), a gain-of function approach was performed to investigate roles of miR-320b, USP37, and CDT1 in lung cancer cell proliferation and invasion. In addition, nude mouse xenograft models were used to study their effects on tumor growth in vivo. miR-320b was poorly expressed in lung cancer patients with OSAH. IH treatment downregulated the expression of miR-320b but promoted the proliferation and invasion capabilities of lung cancer cells, both of which were suppressed by the overexpression of miR-320b through decreasing USP37. USP37 interacted with and deubiquitinated CDT1 to protect it from proteasomal degradation. Our study uncovered that IH-induced downregulation of miR-320b promoted the tumorigenesis of lung cancer by the USP37-mediated deubiquitination of CDT1.
Display omitted
A series of in vivo and in vitro experiments were performed to investigate the functional roles of miR-320b in lung cancer complicated with OSAH. We identified poorly expressed miR-320b in lung cancer with OSAH. It uncovered that intermittent hypoxia-induced miR-320b downregulation promoted lung cancer tumorigenesis via the USP37-mediated deubiquitination of CDT1.
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