We present the analysis of a sample of 35 candidate Compton-thick active galactic nuclei (AGNs) selected in the nearby universe (average redshift ) with the Swift-BAT 100-month survey. All sources ...have available NuSTAR data, thus allowing us to constrain with unprecedented quality important spectral parameters such as the obscuring torus line-of-sight column density (NH,z), the average torus column density (NH,tor), and the torus covering factor (fc). We compare the best-fit results obtained with the widely used MYTorus (Murphy & Yaqoob 2009) model with those of the recently published borus02 model (Balokovi et al. 2018) used in the same geometrical configuration of MYTorus (i.e., with fc = 0.5). We find a remarkable agreement between the two, although with increasing dispersion in NH,z moving toward higher column densities. We then use borus02 to measure fc. High-fc sources have, on average, smaller offset between NH,z and NH,tor than low-fc ones. Therefore, low fc values can be linked to a "patchy torus" scenario, where the AGN is seen through an overdense region in the torus, while high-fc objects are more likely to be obscured by a more uniform gas distribution. Finally, we find potential evidence of an inverse trend between fc and the AGN 2-10 keV luminosity, i.e., sources with higher fc values have on average lower luminosities.
Breast cancer is a leading malignancy affecting the female population worldwide. Most morbidity is caused by metastases that remain incurable to date. TGF-β1 has been identified as a key driving ...force behind metastatic breast cancer, with promising therapeutic implications.
Employing immunohistochemistry (IHC) analysis, we report, to our knowledge for the first time, that asporin is overexpressed in the stroma of most human breast cancers and is not expressed in normal breast tissue. In vitro, asporin is secreted by breast fibroblasts upon exposure to conditioned medium from some but not all human breast cancer cells. While hormone receptor (HR) positive cells cause strong asporin expression, triple-negative breast cancer (TNBC) cells suppress it. Further, our findings show that soluble IL-1β, secreted by TNBC cells, is responsible for inhibiting asporin in normal and cancer-associated fibroblasts. Using recombinant protein, as well as a synthetic peptide fragment, we demonstrate the ability of asporin to inhibit TGF-β1-mediated SMAD2 phosphorylation, epithelial to mesenchymal transition, and stemness in breast cancer cells. In two in vivo murine models of TNBC, we observed that tumors expressing asporin exhibit significantly reduced growth (2-fold; p = 0.01) and metastatic properties (3-fold; p = 0.045). A retrospective IHC study performed on human breast carcinoma (n = 180) demonstrates that asporin expression is lowest in TNBC and HER2+ tumors, while HR+ tumors have significantly higher asporin expression (4-fold; p = 0.001). Assessment of asporin expression and patient outcome (n = 60; 10-y follow-up) shows that low protein levels in the primary breast lesion significantly delineate patients with bad outcome regardless of the tumor HR status (area under the curve = 0.87; 95% CI 0.78-0.96; p = 0.0001). Survival analysis, based on gene expression (n = 375; 25-y follow-up), confirmed that low asporin levels are associated with a reduced likelihood of survival (hazard ratio = 0.58; 95% CI 0.37-0.91; p = 0.017). Although these data highlight the potential of asporin to serve as a prognostic marker, confirmation of the clinical value would require a prospective study on a much larger patient cohort.
Our data show that asporin is a stroma-derived inhibitor of TGF-β1 and a tumor suppressor in breast cancer. High asporin expression is significantly associated with less aggressive tumors, stratifying patients according to the clinical outcome. Future pre-clinical studies should consider options for increasing asporin expression in TNBC as a promising strategy for targeted therapy.
We present the combined NuSTAR and XMM-Newton 0.6-79 keV spectral analysis of a Seyfert 2 galaxy, NGC 1358, which we selected as a candidate Compton-thick (CT) active galactic nucleus (AGN) on the ...basis of previous Swift/BAT and Chandra studies. According to our analysis, NGC 1358 is confirmed to be a CT-AGN using physically motivated models, at >3 confidence level. Our best fit shows that the column density along the line of sight of the obscuring material surrounding the accreting supermassive black hole is NH = (1.96-2.80) × 1024 cm−2. The high-quality data from NuSTAR give the best constraints on the spectral shape above ∼10 keV to date on NGC 1358. Moreover, by combining NuSTAR and XMM-Newton data, we find that the obscuring torus has a low covering factor (fc < 0.17), and the obscuring material is distributed in clumps, rather than uniformly. We also derive an estimate of NGC 1358's Eddington ratio, finding it to be λEdd ∼ × 10−2, which is in acceptable agreement with previous measurements. Finally, we find no evidence of short-term variability, over a ∼100 ks time span, in terms of both line-of-sight column density and flux.
We present an updated catalogue of 113 X-ray flares detected by Swift in the ∼33 per cent of the X-ray afterglows of gamma-ray burst (GRB). 43 flares have a measured redshift. For the first time the ...analysis is performed in four different X-ray energy bands, allowing us to constrain the evolution of the flare temporal properties with energy. We find that flares are narrower at higher energies: their width follows a power-law relation w∝E−0.5 reminiscent of the prompt emission. Flares are asymmetric structures, with a decay time which is twice the rise time on average. Both time-scales linearly evolve with time, giving rise to a constant rise-to-decay ratio: this implies that both time-scales are stretched by the same factor. As a consequence, the flare width linearly evolves with time to larger values: this is a key point that clearly distinguishes the flare from the GRB prompt emission. The flare 0.3–10 keV peak luminosity decreases with time, following a power-law behaviour with large scatter: Lpk∝t−2.7±0.5pk. When multiple flares are present, a global softening trend is established: each flare is on average softer than the previous one. The 0.3–10 keV isotropic energy distribution is a lognormal peaked at 1051 erg, with a possible excess at low energies. The flare average spectral energy distribution is found to be a power law with spectral energy index β∼ 1.1. These results confirmed that the flares are tightly linked to the prompt emission. However, after considering various models we conclude that no model is currently able to account for the entire set of observations.
Context.
The Cygnus Loop (G74.0-8.5) is a very well-known nearby supernova remnant (SNR) in our Galaxy. Thanks to its large size, brightness, and angular offset from the Galactic plane, it has been ...studied in detail from radio to
γ
-ray emission. The
γ
-rays probe the populations of energetic particles and their acceleration mechanisms at low shock speeds.
Aims.
We present an analysis of the
γ
-ray emission detected by the Large Area Telescope on board the
Fermi
Gamma-ray Space Telescope over 11 yr in the region of the Cygnus Loop.
Methods.
We performed detailed morphological and spectral studies of the
γ
-ray emission toward the remnant from 100 MeV to 100 GeV and compared it with X-ray, UV, optical, and radio images. The higher statistics with respect to the previous studies enabled us to decompose the emission from the remnant into two morphological components to model its nonthermal multiwavelength emission.
Results.
The extended
γ
-ray emission is well correlated with the thermal X-ray and UV emission of the SNR. Our morphological analysis reveals that a model considering two contributions from the X-ray and the UV emission regions is the best description of the
γ
-ray data. Both components show a curved spectrum, but the X-ray component is softer and more curved than the UV component, suggesting a different physical origin. The multiwavelength modeling of emission toward the SNR suggests that the nonthermal radio and
γ
-ray emission associated with the UV component is mostly due to the reacceleration of preexisting cosmic rays by radiative shocks in the adjacent clouds, while the nonthermal emission associated with the X-ray component arises from freshly accelerated cosmic rays.
We present the combined Chandra and Swift-BAT spectral analysis of seven Seyfert 2 galaxies selected from the Swift-BAT 100 month catalog. We selected nearby (z ≤ 0.03) sources lacking a ROSAT ...counterpart that never previously been observed with Chandra in the 0.3-10 keV energy range, and targeted these objects with 10 ks Chandra ACIS-S observations. The X-ray spectral fitting over the 0.3-150 keV energy range allows us to determine that all the objects are significantly obscured, with NH ≥ 1023 cm−2 at a >99% confidence level. Moreover, one to three sources are candidate Compton-thick Active Galactic Nuclei (CT-AGNs; i.e., NH ≥ 1024 cm−2). We also test the recent spectral curvature method developed by Koss et al. to find candidate CT-AGNs, finding a good agreement between our results and their predictions. Because the selection criteria we adopted were effective in detecting highly obscured AGNs, further observations of these and other Seyfert 2 galaxies selected from the Swift-BAT 100 month catalog will allow us to create a statistically significant sample of highly obscured AGNs, therefore providing a better understanding of the physics of the obscuration processes.
Introduction
According to the World Health Organization (WHO, 2017) depressive disorder continues to be the most widespread and growing mental illness in the world, also assumes that in 2020 ...depression will have a prevalence equal to one in six individuals. Studies of neuroanatomy have highlighted structural alterations in the hippocampus, striatal nuclei and prefrontal cortex in patients with mood disorders. This alteration in depressed patients is closely related to the secretion of neurotrophic factors, in particular there is a reduction in BDNF (Brain Derived Neurotrophic Factor).
Objectives
The objective of this study is to demonstrate which treatments are effective in reducing depressive symptoms that allow the increase of BDNF and consequently the structural homostaticity of the brain.
Methods
We have selected data from the literature of the last decade, collected on major search engines such as: Google Scholar, Research Gate, PubMed, Ebsco. Articles collected by selecting the following Keyword: depression, BDNF (Brain Derived Neurotrophic Factor), neuroimaging cognitive behavior therapy.
Results
The results show that in patients treated with a single drug treatment or vagus nerve stimulation, repetitive transcranial magnetic stimulation (Lang et al., 2008) or electroconvulsive therapy had improvements in BDNF levels, although compared to drug treatment there are problems of no responders, no compliance and lack of effectiveness in reducing vulnerability to relapse. In addition, the study has shown that patients treated with cognitive behavioral therapy have reported greater changes in the frontal and temporal cortex reducing both depressive symptoms and the risk of relapse.
Conclusions
Underlines the importance of an integrated approach
We use a nearly complete sample of gamma-ray bursts (GRBs) detected by the Swift satellite to study the correlations between the spectral peak energy E
peak of the prompt emission, the isotropic ...energetics E
iso and the isotropic luminosity L
iso. This GRB sample is characterized by a high level of completeness in redshift (90 per cent). This allows us to probe in an unbiased way the issue related to the physical origin of these correlations against selection effects. We find that one burst, GRB 061021, is an outlier to the E
peak-E
iso correlation. Despite this case, we find strong E
peak-E
iso and E
peak-L
iso correlations for the bursts of the complete sample. Their slopes, normalizations and dispersions are consistent with those found with the whole sample of bursts with measured redshift and E
peak. This means that the biases present in the total sample commonly used to study these correlations do not affect their properties. Finally, we also find no evolution with redshift of the E
peak-E
iso and E
peak-L
iso correlations.
Compared to mass transfer in cataclysmic variables, the nature of accretion in symbiotic binaries in which red giants transfer material to white dwarfs (WDs) has been difficult to uncover. The ...accretion flows in a symbiotic binary are most clearly observable, however, when there is no quasi-steady shell burning on the WD to hide them. RT Cru is the prototype of such non-burning symbiotics, with its hard (δ-type) X-ray emission providing a view of its innermost accretion structures. In the past 20 yr, RT Cru has experienced two similar optical brightening events, separated by ~4000 days and with amplitudes of ΔV ~ 1.5 mag. After Swift became operative, the Burst Alert Telescope (BAT) detector revealed a hard X-ray brightening event almost in coincidence with the second optical peak. Spectral and timing analyses of multi-wavelength observations that we describe here, from NuSTAR, Suzaku, Swift/X-Ray Telescope (XRT) + BAT + UltraViolet Optical Telescope (UVOT) (photometry) and optical photometry and spectroscopy, indicate that accretion proceeds through a disk that reaches down to the WD surface. The scenario in which a massive, magnetic WD accretes from a magnetically truncated accretion disk is not supported. For example, none of our data show the minute-time-scale periodic modulations (with tight upper limits from X-ray data) expected from a spinning, magnetic WD. Moreover, the similarity of the UV and X-ray fluxes, as well as the approximate constancy of the hardness ratio within the BAT band, indicate that the boundary layer of the accretion disk remained optically thin to its own radiation throughout the brightening event, during which the rate of accretion onto the WD increased to 6.7 × 10−9M⊙ yr−1 (d/2 kpc)2. For the first time from a WD symbiotic, the NuSTAR spectrum showed a Compton reflection hump at E > 10 keV, due to hard X-rays from the boundary layer reflecting off of the surface of the WD; the reflection amplitude was 0.77 ± 0.21. The best fit spectral model, including reflection, gave a maximum post-shock temperature of kT = 53 ± 4 keV, which implies a WD mass of 1.25 ± 0.02 M⊙. Although the long-term optical variability in RT Cru is reminiscent of dwarf-novae-type outbursts, the hard X-ray behavior does not correspond to that observed in well-known dwarf nova. An alternative explanation for the brightening events could be that they are due to an enhancement of the accretion rate as the WD travels through the red giant wind in a wide orbit, with a period of about ~4000 days. In either case, the constancy of the hard X-ray spectrum while the accretion rate rose suggests that the accretion-rate threshold between a mostly optically thin and thick boundary layer, in this object, may be higher than previously thought.
ABSTRACT
We report on our observing campaign of the compact binary merger GW190814, detected by the Advanced LIGO and Advanced Virgo detectors on 2019 August 14. This signal has the best localization ...of any observed gravitational wave (GW) source, with a 90 per cent probability area of 18.5 deg2, and an estimated distance of ≈240 Mpc. We obtained wide-field observations with the Deca-Degree Optical Transient Imager (DDOTI) covering 88 per cent of the probability area down to a limiting magnitude of w = 19.9 AB. Nearby galaxies within the high probability region were targeted with the Lowell Discovery Telescope (LDT), whereas promising candidate counterparts were characterized through multicolour photometry with the Reionization and Transients InfraRed (RATIR) and spectroscopy with the Gran Telescopio de Canarias (GTC). We use our optical and near-infrared limits in conjunction with the upper limits obtained by the community to constrain the possible electromagnetic counterparts associated with the merger. A gamma-ray burst seen along its jet’s axis is disfavoured by the multiwavelength data set, whereas the presence of a burst seen at larger viewing angles is not well constrained. Although our observations are not sensitive to a kilonova similar to AT2017gfo, we can rule out high-mass (>0.1 M⊙) fast-moving (mean velocity ≥0.3c) wind ejecta for a possible kilonova associated with this merger.
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